“…With the rapid accumulation of microbiome data around the world, numerous computational bioinformatics methods have been developed for pattern mining from such paramount microbiome data. Current microbiome data mining methods, such as gene and species mining, rely heavily on sequence comparison. …”
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“…Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B cell lineages in a viremic controller, two of which comprised only IgG(+) or IgA(+) blood memory B cells; the third combined both IgG and IgA clonal variants. 7-269 bNAb in the IgA-only lineage displayed the highest neutralizing capacity despite limited somatic mutation, and delayed viral rebound in humanized mice. bNAbs in all three lineages targeted the N332 glycan supersite. …”
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“…CONCLUSIONS: Protection of our team and our patients from the risk of COVID-19 infection was paramount given the high mortality rate and disease duration. …”
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“…The predicted climate change phenomena point to warmer and dryer Mediterranean environmental conditions; as such, it is paramount to study the effects of abiotic stress on grapevine performance. …”
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“…An awareness of how one’s cognitive biases and heuristics may adversely impact on this cognitive process is paramount, as is an understanding of the calibration between fast and slow thinking. …”
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“…Therefore, guiding children on the correct use of electronic devices and helping them eat healthy are paramount during this COVID-19 pandemic.…”
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“…Because global climate change will increasingly influence plant health and resilience, it is paramount to fundamentally understand how these two tightly linked plant signals are at the nexus of the growth-defense balance.…”
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“…Third, for progressing to nature-positive cities, it is paramount to empower communities to innovate with nature across Australian cities. …”
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“…As policies to eliminate Medicaid access restrictions to HCV treatment are expanded, patient education is paramount to achieving HCV elimination targets in difficult-to-engage populations including persons experiencing homelessness. …”
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“…As such, altered cell adhesion properties are paramount to EOC metastasis with cell detachment from the primary tumor, dissemination as spheroids, and reattachment to peritoneal surfaces for secondary tumor formation. …”
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“…Sustainable wildlife management could enhance the nutritional benefits of wildlife for vulnerable Amazonians, but reducing multidimensional poverty and improving access to quality healthcare are paramount.…”
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“…A correct diagnosis is paramount for proper treatment of the disease that requires both surgical and medical actions to be taken.…”
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“…The homeostatic control of Sodium (Na(+)) ion in the human body assumes paramount relevance owing to its physiological importance. …”
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“…The impact of the cost of the procedure and quality of life are of paramount importance in choosing the type of intervention. …”
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“…The occurrence of diarrheal infections depends on the level of water and sanitation services available to households of immunocompromised individuals and children of less than five years old. It is therefore of paramount importance for immunocompromised individuals to be supplied with safe drinking water for better health outcomes. …”
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“…However, there are huge variations across the years and the countries. The study is of paramount importance to initiate a debate amongst the concerned policymakers and stakeholders to regularly monitor the disaster-induced mortality rates. …”
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“…Identifying factors affecting mental health and causing suicidal ideation is of paramount importance for timely intervention and suicide prevention. …”
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“…Early diagnosis and prompt treatment of this deadly disease are of paramount importance in improving patient survival. …”
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“…The computer-aided and structure-based design of ligands affecting cluster release is of paramount importance from a pharmaceutical perspective. …”
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“…The emergence of new genes and functions is of paramount importance in the emergence of new animal species. …”
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