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  1. 4801
    “…The histological manifestation of MF can be subtle in early‐stage disease and therefore a careful clinicopathological correlation is paramount. The treatment of MF/SS is dependent on the disease stage. …”
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    Mycosis fungoides and Sézary syndrome
  2. 4802
    “…Considering the vast biological diversity and high mortality rate in high-grade ovarian cancers, identification of novel biomarkers, enabling precise diagnosis and effective, less aggravating treatment, is of paramount importance. Based on scientific literature data, we selected 80 cancer-related genes and evaluated their mRNA expression in 70 high-grade serous ovarian cancer (HGSOC) samples by Real-Time qPCR. …”
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    PROM1, CXCL8, RUNX1, NAV1 and TP73 genes as independent markers predictive of prognosis or response to treatment in two cohorts of high-grade serous ovarian cancer patients
  3. 4803
    “…BACKGROUND: During the pandemic and with the growing shortage of nurses, the problem of how to retain existing nurses was of paramount importance. However, there is limited evidence on the relationship between nurses' self-acceptance and intention to stay. …”
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    Relationship Between Self-Acceptance and Intention to Stay at Work Among Clinical Nurses in China: A Cross-Sectional Online Survey
  4. 4804
    “…Aggressive prevention, prompt diagnosis and timely rescue of any major adverse events following the procedure remain paramount clinical needs.…”
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    Peri-Operative Management of Patients Undergoing Fenestrated-Branched Endovascular Repair for Juxtarenal, Pararenal and Thoracoabdominal Aortic Aneurysms: Preventing, Recognizing and Treating Complications to Improve Clinical Outcomes
  5. 4805
    “…Therefore, chitin and chitinolytic enzymes are becoming more importance for biotechnological applications in food, health and agricultural fields, the design of effective enzymes being a paramount issue. We report the crystal structure of the plant-type endo-chitinase Chit33 from Trichoderma harzianum and its D165A/E167A-Chit33-(NAG)(4) complex, which showed an extended catalytic cleft with six binding subsites lined with many polar interactions. …”
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    Structure–Function Insights into the Fungal Endo-Chitinase Chit33 Depict its Mechanism on Chitinous Material
  6. 4806
    “…The safety and biocompatibility of surgical sealants are of paramount importance therefore, the aim of this study is to investigate the biocompatibility of NE’X Glue Surgical Adhesive. …”
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    Biocompatibility of novel albumin-aldehyde surgical adhesive
  7. 4807
    “…In this context, short- and long-term negative effects of psychological reactions may exist, thus urgent strategies to mitigate such a burden is paramount. This chapter discusses the psychological aspects during the COVID-19 by exploring the psychological reactions to this global pandemic of the general population and those involved in the healthcare sector. …”
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    Effect of the COVID-19 pandemic on psychological aspects
  8. 4808
    “…Heat shock protein 70 (Hsp70) is a molecular chaperone and central regulator of protein homeostasis (proteostasis). Paramount to this role is Hsp70’s binding to client proteins and co-chaperones to produce distinct complexes, such that understanding the protein–protein interactions (PPIs) of Hsp70 is foundational to describing its function and dysfunction in disease. …”
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    Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes
  9. 4809
    “…The biomechanical characteristics of the patellar tendon, such as elasticity and stiffness, are of paramount importance and constitute major outcome measures in research studies. …”
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    Ex vivo study correlating the stiffness of the ovine patellar tendon to age and weight
  10. 4810
    “…Compressive strength (CS) and splitting tensile strength (STS) are paramount parameters in the design of reinforced concrete structures and are required by pertinent standard provisions. …”
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    Predicting Compressive and Splitting Tensile Strengths of Silica Fume Concrete Using M5P Model Tree Algorithm
  11. 4811
    “…The assessment of muscle health is of paramount importance, as the loss of muscle mass and strength can affect performance. …”
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    Protocol and reference values for minimal detectable change of MyotonPRO and ultrasound imaging measurements of muscle and subcutaneous tissue
  12. 4812
    “…COVID-19 prevention through successful vaccination is therefore paramount in this vulnerable population. Although patients receiving dialysis have seroconversion rates comparable to those of patients with normal kidney function, most kidney transplant recipients could not generate humoral immunity after two doses of the COVID-19 vaccine. …”
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    Vaccination in patients with kidney failure: lessons from COVID-19
  13. 4813
    “…However, appropriate patient selection and preoperative diagnosis are of paramount importance to achieve excellent outcomes. …”
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    Increasing Collaboration between Headache Medicine and Plastic Surgery in the Surgical Management of Chronic Headache
  14. 4814
    “…Background: Self-monitoring of blood glucose (SMBG) is of paramount relevance for type 2 diabetes mellitus (T2DM) patients. …”
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    Glucometer Usability for 65+ Type 2 Diabetes Patients: Insights on Physical and Cognitive Issues
  15. 4815
    “…With the increasing demand for hospital services amidst the COVID-19 pandemic, allocation of limited public resources and management of healthcare services are of paramount importance. In the field of patient flow scheduling, previous research primarily focused on classical-based objective functions, while ignoring environmental-based objective functions. …”
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    Application of job shop scheduling approach in green patient flow optimization using a hybrid swarm intelligence
  16. 4816
    “…History of other fatigue injuries seems to be a predisposing factor. It is of paramount importance to obtain advanced imaging for identifying a FSF.…”
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    Fatigue sacral fractures: A case series and literature review
  17. 4817
    “…LEARNING POINTS: Percutaneous mechanical thrombectomy using the FlowTriever or similar devices can be paramount in reducing morbidity and mortality from an intermediate- to high-risk pulmonary embolism given the immediate improvement in haemodynamics that cannot be achieved by anticoagulation alone. …”
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    A Novel Case of Cardiac Tamponade after Percutaneous Pulmonary Embolectomy Using the FlowTriever Retrieval/Aspiration System
  18. 4818
    “…Control over the agglomeration state of manufactured particle systems for drug and oligonucleotide intracellular delivery is paramount to ensure reproducible and scalable therapeutic efficacy. …”
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    Deagglomeration of DNA nanomedicine carriers using controlled ultrasonication
  19. 4819
    “…More investigation into the differentiation of patients and ideal type of coercive measure is paramount to the ambitions of a better and more humanistic psychiatric care.…”
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    Manual and mechanical restraint and the hierarchy of coercive measures: Evidence or tradition?
  20. 4820
    “…Overall, a more refined insight into the mechanisms and functionality of HBV integration is paramount, since it can potentially inform the design of ad hoc diagnostic tools with the ability to reveal HBV integration events perturbating relevant intracellular pathways and for identifying novel therapeutic strategies targeting alterations directly related to HBV integration.…”
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    Hepatitis B virus DNA integration as a novel biomarker of hepatitis B virus-mediated pathogenetic properties and a barrier to the current strategies for hepatitis B virus cure
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