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  1. 4861
    “…Timely detection and repair of envelope damage are paramount for bacterial survival. The Regulator of Capsule Synthesis (Rcs) stress response can transduce the stress signals across the multilayered gram-negative cell envelope to regulate gene expression in the cytoplasm. …”
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    Conformational rearrangements in the sensory RcsF/OMP complex mediate signal transduction across the bacterial cell envelope
  2. 4862
    “…Interaction of NS1 with the host proteins PI3K and TRIM25 is paramount for NS1’s role in infection and pathogenesis by promoting viral replication through the inhibition of apoptosis and suppressing interferon production, respectively. …”
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    Unveiling New Druggable Pockets in Influenza Non-Structural Protein 1: NS1–Host Interactions as Antiviral Targets for Flu
  3. 4863
    “…Among social insects, task allocation within its group members remains as one of the paramount pillars of social functionality. Division of labor in many eusocial insects is maintained by behavioral flexibility that can shift according to the needs of the colony they reside in. …”
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    Family before work: task reversion in workers of the red imported fire ant, Solenopsis invicta in the presence of brood
  4. 4864
    “…Introduction With the spread of the Covid-19 pandemic and its overwhelming impact on health systems in several countries, the importance of identifying predictors of severity is of paramount importance. The objective of this study is to determine the relationship between death and the biological parameters of patients with Covid-19. …”
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    Biomarkers Predicting Poor Prognosis in Covid-19 Patients: A Survival Analysis
  5. 4865
    “…Therefore, the identification of molecules capable of inhibiting the binding between the ACE2 receptor and the SARS-CoV-2 spike protein is of paramount importance. Recently, two DNA aptamers were designed with the aim to inhibit the interaction between the ACE2 receptor and the spike protein of SARS-CoV-2. …”
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    Investigating the competition between ACE2 natural molecular interactors and SARS-CoV-2 candidate inhibitors
  6. 4866
    “…With this regard, liver regeneration strategies have become paramount in transforming patients who previously had poor prognoses into ones who, after major hepatic resection with negative margins, have had their risk of post-hepatectomy liver failure minimized. …”
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    Portal Vein Embolization: Rationale, Techniques, and Outcomes to Maximize Remnant Liver Hypertrophy with a Focus on Contemporary Strategies
  7. 4867
    “…Educating patients about the treatment and maintaining their well-being is paramount for preventing discontinuation. Putting in place checklists can be a useful strategy for ensuring treatment appointments run smoothly and safely. …”
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    Early Clinical Experiences of Esketamine Nasal Spray in the UK in Adults with Treatment-Resistant Major Depressive Disorder: Advisory Panel Recommendations
  8. 4868
    “…Paleomagnetism is the study of the fossil magnetism in rocks. It has been paramount in determining that the continents have drifted over the surface of the Earth throughout geological time. …”
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    Paleomagnetism: continents and oceans
  9. 4869
    “…It has been conceived to be able to adapt to different test frames both dynamic and static, which will be of paramount importance for future studies of fracture mechanics at low temperatures. …”
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    Design and fabrication of a cryostat for low temperature mechanical testing for the Mechanical and Materials Engineering group at CERN
  10. 4870
    “…The understanding of the mechanical behaviour of the CS module coils is of paramount importance to analyse and predict the overall response of the CS stack. …”
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    Examination and Characterization of Physical and Mechanical Properties of the ITER Central Solenoid Module Coils
  11. 4871
    por Kondratyev, Dmitry
    Publicado 2022
    “…After the discovery of the Higgs boson, the measurement of its properties, such as its couplings to other particles, is of paramount importance. The projects described in this thesis explore different aspects of one of such measurements – the search for the Higgs boson decay into a pair of muons ($\mathrm{H}\to\mu\mu$), conducted by the CMS experiment at the LHC. …”
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    Search for the Higgs boson decaying to a pair of muons with the CMS experiment at the Large Hadron Collider
  12. 4872
    por Schumacher, Thorsten Martin
    Publicado 2023
    “…The analysis of beam losses and detection of anomalies during particle collision experiments in the Large Hadron Collider is of paramount importance to ensure the integrity and safety of the machine’s equipment. …”
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    Anomaly Detection with Artificial Intelligence: Post-mortem analysis of LHC ion beam losses during high-energy beam dumps
  13. 4873
    “…The achievement of a fine and homogeneous microstructure, which is of paramount importance for final inspectability of the parts and to obtain the mechanical properties, is particularly challenging taking into account their large size. …”
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    Examination and Assessment of Large Forged Structural Components for the Precompression Structure of the ITER Central Solenoid
  14. 4874
    “…Given that a significant fraction of buildings and architectural heritage in Europe’s historical centers are masonry structures, the selection of proper diagnosis, technological surveys, non-destructive testing, and interpretations of crack and decay patterns is paramount for a risk assessment of possible damage. …”
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    A Brief Overview on Crack Patterns, Repair and Strengthening of Historical Masonry Structures
  15. 4875
    “…The detection and functionality of new resistance genes are of paramount importance in applying more effective screening methods based on whole genome sequencing (WGS). …”
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    Low-Level Tetracycline Resistance Gene tet(O)_3 in Campylobacter jejuni
  16. 4876
    “…Therefore, the identification of new molecular biomarkers and therapeutic targets related to cancer diagnosis and prognosis is of paramount importance. DNA polymerase delta 1 (POLD1), a catalytic and proofreading subunit of the DNA polymerase δ complex, performs a crucial role in DNA replication and repair processes. …”
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    Prospects of POLD1 in Human Cancers: A Review
  17. 4877
    “…Abnormal tau build-up is a hallmark of Alzheimer’s disease (AD) and more than 20 other serious neurodegenerative diseases. Mitochondria are paramount organelles playing a predominant role in cellular bioenergetics, namely by providing the main source of cellular energy via adenosine triphosphate generation. …”
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    Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein
  18. 4878
    “…There is general agreement that a paramount issue to avoid transmission of infection in occupational settings is an appropriate decontamination of often-touched surfaces and usage of appropriate personal protective equipment by the workers at high risk of infection. …”
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    Monkeypox (Mpox) and Occupational Exposure
  19. 4879
    “…Standardized assays for testing vaccine immunogenicity are paramount for the development of vaccines, and so in this study, we optimized and standardized both antibody-level and function assays for evaluating in-development K. pneumoniae bioconjugate vaccine response in rabbits.…”
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    The Development of Immunological Assays to Evaluate the Level and Function of Antibodies Induced by Klebsiella pneumoniae O-Antigen Vaccines
  20. 4880
    “…These directions are of paramount importance during the current SARS-CoV-2 global health crisis.…”
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    Controversial Properties of Amyloidogenic Proteins and Peptides: New Data in the COVID Era
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