“…Thus, identifying potential biomarkers that can reflect the pathogenic mechanisms, disease course and prognosis, and therapeutic response in such patients is of paramount importance. Myelin oligodendrocyte glycoprotein (MOG) has been regarded as a putative autoantigen and autoantibody target in patients with demyelinating diseases for almost three decades. …”
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“…INTERPRETATION: These findings are of paramount importance and provide an ideal cell source for autologous skin regeneration. …”
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“…In powder bed fusion additive manufacturing, the powder feedstock quality is of paramount importance; as the process relies on thin layers of powder being spread and selectively melted to manufacture 3D metallic components. …”
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“…Thus, preoperative imaging corroborated with naso-endoscopy is of paramount importance to trace the lesion along ethmoid pneumatization, and determine the relative positions of structures vulnerable to surgery. …”
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“…From their perspective, disrespect, physical threat, property damage, and physical violence were of paramount importance. 61.8% of them argued that they had “sometimes” and “always” experienced “unfair assessment” during the last year. …”
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“…Tackling these goals is a complex task demanding the combination of different perspectives including building and urban Architecture, Ubiquitous Computing and Human-Computer Interaction (HCI) to provide occupants with the means to shape these environments to their needs. Interaction is of paramount relevance in the creation of adequate relations of users with their environments, but it cannot be seen independently from the ubiquitous sensing and computing or the environment’s architecture. …”
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“…Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. …”
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“…Epoxyeicosatrienoic acids (EETs) generated by the CYP450 enzyme also plays a paramount role in the kidney damage during the inflammation process. …”
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“…Furthermore, our findings underline that ether lipids are paramount for brain function and demonstrate their relevance for cognitive, social, and emotional behavior. …”
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“…Robust and centimeter-level Real-time Kinematic (RTK)-based Global Navigation Satellite System (GNSS) positioning is of paramount importance for emerging GNSS applications, such as drones and automobile systems. …”
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“…The lack or instability of the pension system for the elderly in rural China has become a paramount obstacle for sustainable land transfer, namely land use right transfer among farmers, in the context of aging. …”
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“…Thus, tuning physico-electrochemical properties of these materials is of paramount importance. An even greater problem is to obtain a desired dopant configuration which allows control over device sensitivity and enhanced reproducibility. …”
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“…Among their potential effects, the potential for DNA damage is of paramount relevance. Thus, in the context of the EU project NANoREG, the establishment of common robust protocols for detecting genotoxicity of NMs became an important aim. …”
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“…In this perspective, it is paramount to highlight physiological mechanisms of plant responses to altitudinal gradients as a proxy to evaluate changing environments. …”
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“…The design and optimization of memristive devices for specific AI applications is thus of paramount importance, but still extremely complex, as many different physical mechanisms and their interactions have to be accounted for, which are, in many cases, not fully understood. …”
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“…Advanced understanding of the molecular mechanisms underlying cell cycle-related death is of paramount importance because this knowledge can be applied to develop protective strategies against pathologies in postmitotic tissues. …”
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“…Since the echinocandins, antifungals widely used to treat invasive mycoses, are still unavailable in developing countries where a considerable number of problematic fungal species are present, rapid and reliable identification is of paramount importance. Unaffordability, large footprints, lack of skilled personnel, and high costs associated with maintenance and infrastructure are the main factors precluding the establishment of high-precision technologies that can replace inexpensive yet time-consuming and inaccurate phenotypic methods. …”
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“…Understanding the processes involved in pacemaker activity is of paramount importance for a basic physiological knowledge, but also as a way to reveal details of pathological dysfunctions useful in the perspective of a therapeutic approach. …”
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“…The generation of variation is paramount for the action of natural selection. Although biologists are now moving beyond the idea that random mutation provides the sole source of variation for adaptive evolution, we still assume that variation occurs randomly. …”
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“…Mapping the pathomechanism and providing novel therapeutic options have paramount significance. Recent studies have proposed the role of LMTK2 in AD. …”
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