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  1. 5181
    “…CONCLUSION: This case highlights several important issues: the bewildering myriad of clinical features of carbon monoxide poisoning, the importance of making the diagnosis even at a late stage and preventing the patient's return to a potentially fatal toxic environment, and the paramount importance of the history in the diagnostic method.…”
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    Accidental carbon monoxide poisoning presenting without a history of exposure: A case report
  2. 5182
    “…However, when developing probes for the quantitative analysis of rearrangements involving genomic intervals of less than 100 kb, careful probe selection and characterization are of paramount importance. RESULTS: We describe a sensitive approach to quality control probe clones suspected of carrying deletions or for measuring clone overlap with near kilobase resolution. …”
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    Validation of DNA probes for molecular cytogenetics by mapping onto immobilized circular DNA
  3. 5183
    “…Thus characterising the mechanistic basis for the Fas/FADD interaction is paramount for understanding DISC signaling but has remained enigmatic largely due to a lack of structural data. …”
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    The Fas/FADD death domain complex structure unravels signaling by receptor clustering
  4. 5184
    “…Assessing the quality of stored urine for molecular analysis, by using the type of strategy described here, is paramount before these samples are used for molecular prognostic monitoring, genetic analyses and disease diagnosis.…”
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    Implications of Storing Urinary DNA from Different Populations for Molecular Analyses
  5. 5185
    “…BACKGROUND: IgE antibodies play a paramount role in the pathogenesis of various intestinal disorders. …”
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    The High Affinity IgE Receptor FcεRI Is Expressed by Human Intestinal Epithelial Cells
  6. 5186
    “…Several anatomic and physiologic considerations are paramount regarding ureteral injuries management. LITERATURE REVIEW: Eighty-one articles pertaining to traumatic ureteral injuries were reviewed. …”
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    A review of ureteral injuries after external trauma
  7. 5187
    “…Accordingly, IL-32β increased adhesion of inflammatory cells to activated endothelial cells, a paramount process in inflammation. These results illustrate a positive feedback regulation that intensifies and prolongs inflammation. …”
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    Interleukin-32β Propagates Vascular Inflammation and Exacerbates Sepsis in a Mouse Model
  8. 5188
    “…The development of antibodies effective in crossing the blood brain barrier (BBB), capable of accessing the cytosol of affected cells and with higher affinity for PrP(Sc) would be of paramount importance in arresting disease progression in its late stage and treating individuals with prion diseases. …”
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    A Camelid Anti-PrP Antibody Abrogates PrP(Sc) Replication in Prion-Permissive Neuroblastoma Cell Lines
  9. 5189
    “…It is well known that the PCR technique provides high sensitivity and specificity in detecting parasite DNA. Therefore it is of paramount importance to take advantage of its excellent performance by providing a simple to handle and reliable DNA extraction procedure, which permits the diagnosis of the disease in easily obtainable urine samples. …”
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    A salting out and resin procedure for extracting Schistosoma mansoni DNA from human urine samples
  10. 5190
    “…Thus, the identification of insect genes involved in conferring resistance is of paramount importance. A colony of Spodoptera exigua (Lepidoptera: Noctuidae) was selected for 15 years in the laboratory for resistance to Xentari™, a B. thuringiensis-based insecticide, reaching a final resistance level of greater than 1,000-fold. …”
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    Constitutive Activation of the Midgut Response to Bacillus thuringiensis in Bt-Resistant Spodoptera exigua
  11. 5191
    “…We discuss the need for 'compassionate use' programmes and their regulation where protection of patients is paramount. CONCLUSIONS: 'Compassionate use' is a misleading term and should be replaced with 'expanded access'. …”
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    Compassionate use of interventions: results of a European Clinical Research Infrastructures Network (ECRIN) survey of ten European countries
  12. 5192
    “…Considering the potential for pandemic spread, understanding the development of immunity is paramount to the development of effective counter measures against CHIKV. …”
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    A DNA Vaccine against Chikungunya Virus Is Protective in Mice and Induces Neutralizing Antibodies in Mice and Nonhuman Primates
  13. 5193
    “…Impurity characterization of such drugs, which are widely consumed in tropical countries for malaria control programmes, is of paramount importance. However, until now, no exhaustive impurity profile of lumefantrine has been established, encompassing process-related and degradation impurities in active pharmaceutical ingredients (APIs) and finished pharmaceutical products (FPPs). …”
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    Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine
  14. 5194
    “…BACKGROUND: The discovery of surprisingly frequent patterns is of paramount interest in bioinformatics and computational biology. …”
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    Efficient algorithms for the discovery of gapped factors
  15. 5195
    “…The development of antibodies with binding capacity towards soluble oligomeric forms of PrPSc recognised in the aggregation process in early stage of the disease would be of paramount importance in diagnosing prion diseases before extensive neuropathology has ensued. …”
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    PrP(Sc)-Specific Antibodies with the Ability to Immunodetect Prion Oligomers
  16. 5196
    “…Therefore, the development of new and more effective drugs is of paramount importance. Although some host cellular factors that play a role in T. cruzi infection have been uncovered, the molecular requirements for intracellular parasite growth and persistence are still not well understood. …”
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    Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection
  17. 5197
    “…With growing concerns over multidrug resistance microorganisms, particularly strains of bacteria and fungi, evolving to become resistant to the antimicrobial agents used against them, the identification of new molecular targets becomes paramount for novel treatment options. Recently, the use of new treatments containing multiple active ingredients has been shown to increase the effectiveness of existing molecules for some infections, often with these added compounds enabling the transport of a toxic molecule into the infecting species. …”
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    Development of Non-Natural Flavanones as Antimicrobial Agents
  18. 5198
    por Correa, Elon, Goodacre, Royston
    Publicado 2011
    “…BACKGROUND: The rapid identification of Bacillus spores and bacterial identification are paramount because of their implications in food poisoning, pathogenesis and their use as potential biowarfare agents. …”
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    A genetic algorithm-Bayesian network approach for the analysis of metabolomics and spectroscopic data: application to the rapid identification of Bacillus spores and classification of Bacillus species
  19. 5199
    “…BACKGROUND: The cell-cycle checkpoint kinase Chk1 is essential in mammalian cells due to its roles in controlling processes such as DNA replication, mitosis and DNA-damage responses. Despite its paramount importance, how Chk1 controls these functions remains unclear, mainly because very few Chk1 substrates have hitherto been identified. …”
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    A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
  20. 5200
    “…CONCLUSION: These diagnostic molecular tools are of paramount importance in establishing etiology, serogrouping, and epidemiological surveillance especially in developing countries like India.…”
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    Direct detection and serogroup characterization of Neisseria meningitidis from outbreak of meningococcal meningitis in Delhi
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