“…We found that in particular the exposure of nsp8's natural N-terminal residue was paramount for both the protein's ability to associate with nsp7 and for boosting its RdRp activity. …”
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“…BACKGROUND: The ability of peripheral nerves to stretch and slide is thought to be of paramount importance to maintain ideal neural function. …”
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“…Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. …”
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“…The independent mortality risk factors in the Cox proportional hazard regression model were higher plasma pro-atrial natriuretic peptide (pro-ANP) (p = 0.006), lower residual diuresis (p = 0.048), and lower systolic blood pressure (BP) value (p = 0.039). CONCLUSIONS: Paramount for the survival of the elderly on dialysis is adequate extracellular volume control. …”
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“…The phosphoprotein phosphatases PP1 and PP2A are paramount for the timely execution of mitotic entry and exit but their interaction partners and substrates are still largely unresolved. …”
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“…Since the perceived high bleeding risk of TT may deny patients effective strategies, the determination of the true safety profile of TT is of paramount importance. METHODS: All the 27 published studies where the incidence of bleeding at various time points during follow-up has been reported separately for patients on TT were reviewed, and the weakness of the data was analyzed. …”
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“…Identifying the mechanisms that govern synapse degeneration is of paramount importance, as cognitive decline is strongly correlated with loss of presynaptic terminals in these disorders. …”
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“…The need of natural antimicrobials is paramount to avoid harmful synthetic chemicals. The study aimed to determine the antifungal activity of natural compound chitosan and its nanoparticles forms against Candida albicans, Fusarium solani and Aspergillus niger. …”
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“…The goal of any procedure is to perform it properly and safely; thus, early recognition of complications when they do occur is paramount in dictating prevention of long-term sequelae. …”
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“…BACKGROUND: Optimal adherence to imatinib therapy is of paramount importance to maximise treatment effectiveness in patients with chronic myeloid leukaemia (CML). …”
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“…BACKGROUND: Unmanaged or old-growth forests are of paramount importance for carbon sequestration and thus for the mitigation of climate change among further implications, e.g. biodiversity aspects. …”
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“…Primary stability is considered of paramount importance to achieve osseointegration. The purpose of the present study was to investigate the correlation between the insertion torque and primary stability of dental implants using artificial bone blocks with different bone densities and compositions to mimic different circumstances that are encountered in routine daily clinical settings. …”
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“…Patients who are systemically immunosuppressed are at greatest risk and early suspicion of the role of this organism in patients with acute panuveitis is paramount. FINDINGS: A 66-year-old cardiac transplant patient on oral prednisone, Myfortic, and tacrolimus developed unilateral panuveitis with a focal white subretinal and retinal lesion. …”
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“…Protection of intact wetland complexes and the reduction of introduced species populations are paramount to preserving populations of native species.…”
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“…Such information is of paramount importance for making sense of several phenotypic differences observed between these strains. …”
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“…BACKGROUND: The identification of skeletal remains is of paramount importance in medico-legal investigations. …”
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“…Compositional analyses of human body fluids are therefore of paramount diagnostic importance. Further improving their comprehensiveness should increase our understanding of inter-organ communication. …”
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“…In all areas of blood management, from blood donations to transfusions, continuous developments in monitoring safety standards and practices are paramount.…”
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“…Identifying the molecular variables playing key roles in this process would be of paramount importance to shed light on the mechanisms known to counteract the negative effects of oxygen lack. …”
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“…Since determining the effective variables in the quality of nurse-patient relationships in clinical settings is of paramount importance, current investigation is an effort to examine the relationship between attachment styles and empathy in nursing students. 260 university students (male = 130 and female = 130) were chosen as the sample of the study based upon specific inclusion criteria. …”
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