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  1. 5521
    “…MOTIVATION: Recapitulating aspects of human organ functions using in vitro (e.g. plates, transwells, etc.), in vivo (e.g. mouse, rat, etc.), or ex vivo (e.g. organ chips, 3D systems, etc.) organ models is of paramount importance for drug discovery and precision medicine. …”
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    An information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures
  2. 5522
    “…Cardiac manifestations from COVID-19 include but are not limited to, acute myocardial injury, cardiac arrhythmias, congestive heart failure and acute coronary syndrome. Cardiac imaging is paramount to appropriately diagnose and manage the cardiac manifestations of COVID-19. …”
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    Contemporary use of cardiac imaging for COVID-19 patients: a three center experience defining a potential role for cardiac MRI
  3. 5523
    “…We believe that stronger efforts by authorities are necessary to facilitate completing postmortem examinations, as data derived from such assessments are expected to be paramount to improving patient management and disease prevention.…”
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    The roles of medical examiners in the COVID-19 era: a comparison between the United States and Italy
  4. 5524
    “…It is a wake-up call to societies and nations, to dedicate paramount attention to slums into recovery and beyond – to build, restore and maintain health equity for the ‘Health and wellbeing of all’.…”
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    High seroprevalence of COVID-19 infection in a large slum in South India; what does it tell us about managing a pandemic and beyond?
  5. 5525
    “…Patients with FM showed lower levels of ml/Cr (P = 0.037) in the right insula than healthy controls. These findings are paramount to understand decisive pathophysiological mechanisms related to abnormal features in the brain and parasympathetic nervous systems in FM. …”
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    Abnormal neurometabolites in fibromyalgia patients: Magnetic resonance spectroscopy study
  6. 5526
    por Gorayski, Peter, Dzienis, Marcin
    Publicado 2020
    “…Due to increasing complexity of melanoma therapy, a multidisciplinary approach is of paramount importance.…”
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    Complete clinical response of a neglected cutaneous melanoma with combined radiotherapy and immunotherapy: A case report
  7. 5527
    “…Studying cancers in well-tuned 3D cell culture platforms is paramount to bring mechanomedicine into the realm of oncology.…”
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    3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research
  8. 5528
    “…Hence, understanding the molecular mechanisms involved in the multistep process of breast cancer bone metastasis and tumor-induced osteolysis is of paramount interest. The serine/threonine kinase AKT plays a crucial role in breast cancer bone metastasis but the effect of individual AKT isoforms remains unclear. …”
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    Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
  9. 5529
    “…New strategies must be developed; therefore, restoration of β-lactam efficacy through the use of β-lactamase inhibitors is paramount. Activities of the antibiotics imipenem, meropenem, cefepime, and sulbactam in combination with the penicillin-sulfone inhibitor LN-1-255 were tested by microdilution against 148 isolates of Acinetobacter spp. collected in 14 hospitals in Spain in 2020. …”
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    Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp.
  10. 5530
    “…As Uttarakhand—a hilly, EAG state of north India—would also be part of this nation-wide drive; prior identification of RCH services coverage in the State assumes paramount importance, as it reflects probable executability of GDM screening services within its delivery platform. …”
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    A step towards real-time implementation of GDM guidelines in India: Review of Gaps in RCH Programme
  11. 5531
    “…The combination of factors such as antigen structure and conformation, delivery method, and receptor specificity is of paramount importance. During the last decades, research provided many tools that can specifically target various receptors on DCs to induce a tolerogenic phenotype. …”
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    Tolerogenic Immunotherapy: Targeting DC Surface Receptors to Induce Antigen-Specific Tolerance
  12. 5532
    “…Whether terrestrial life can withstand the martian environment is of paramount interest for planetary protection measures and space exploration. …”
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    MARSBOx: Fungal and Bacterial Endurance From a Balloon-Flown Analog Mission in the Stratosphere
  13. 5533
    “…For organic devices such as diodes and transistors, higher charge carrier mobilities are paramount to achieve high performance. Organic single crystals have been shown to offer these required high mobilities. …”
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    Doped Highly Crystalline Organic Films: Toward High‐Performance Organic Electronics
  14. 5534
    “…In view of all these challenges, it is paramount to strengthen the German Public Health Service in general and at points of entry and to intensify the exchange between the national, federal state and local levels.…”
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    Flug- und Schiffsverkehr während der COVID-19-Pandemie in Deutschland: Herausforderungen für den Öffentlichen Gesundheitsdienst
  15. 5535
    “…BACKGROUND: Platelet transfusion is among the most useful therapeutic tools in modern clinical settings which mean that ensuring an adequate supply is of paramount importance. AIM: The aim of our study was to record the use and wastage of platelet concentrates (PCs) in Greece, so as to come up with evidence-based interventions. …”
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    Platelets transfusion in Greece: Where, when, why? A national survey
  16. 5536
    por Chen, Emily, Deb, Ashok, Ferrara, Emilio
    Publicado 2021
    “…The study of online chatter is paramount, especially in the wake of important voting events like the recent November 3, 2020 U.S. …”
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    #Election2020: the first public Twitter dataset on the 2020 US Presidential election
  17. 5537
    “…In this respect, assessments of resource consumption and the delivery of appropriate policies to support resource conservation are of paramount importance. Previous works in the literature have focused on one specific resource (e.g., water, energy, food) at the household level, while others have analysed the inter-relations among different resources (i.e., the nexus approach) at larger spatial scales (e.g., urban level). …”
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    Simulations of scenarios for urban household water and energy consumption
  18. 5538
    “…Aiming at continuous unobtrusive respiration monitoring, motion robustness is paramount. However, some types of motion can completely hide the respiration information and the detection of these events is required to avoid incorrect rate estimations. …”
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    Towards Continuous Camera-Based Respiration Monitoring in Infants
  19. 5539
    “…In order to satisfy the learners and to impart them quality knowledge and education, e-learning content comprising of excellent learning and website content is of paramount importance. In the present COVID-19 outbreak challenging times the significance of e-learning system development and its application is much more pronounced. …”
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    Learner-content interaction in e-learning- the moderating role of perceived harm of COVID-19 in assessing the satisfaction of learners
  20. 5540
    “…INTRODUCTION: Because a primary focus of Centers of Biomedical Research Excellence (COBRE) is the development of junior-level investigators into competent and successful research scientists, evaluation of their skills, mentoring experiences, and usefulness of COBRE services is paramount to the transition of the Center to a self-sustaining, collaborative, multidisciplinary research environment. …”
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    Formative evaluation results of a phase 2 Center of Biomedical Research Excellence (COBRE)
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