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  1. 5541
    “…CONCLUSION: Greater transparency and precision are paramount to improving the evidence base for responsible product design to mitigate gambling-related harm.…”
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    Responsible product design to mitigate excessive gambling: A scoping review and z-curve analysis of replicability
  2. 5542
    “…Proper skin barrier function is paramount for our survival, and, suffering injury, there is an acute need to restore the lost barrier and prevent development of a chronic wound. …”
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    Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs
  3. 5543
    por Kollareddy, Madhu, Martinez, Luis A.
    Publicado 2021
    “…Mutant p53(s) are widely considered as oncogenes and promote several gain-of-function oncogenic activities. p53 mutations correlate with higher rates of metastasis and poor survival; therefore, it is paramount to inhibit mutant p53 protein either directly or indirectly. …”
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    Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line
  4. 5544
    “…As diagnosis of PIMS-TS should be made promptly, timing of therapy is of paramount importance for a favorable outcome. To date, no randomized controlled trial data exist concerning treatment recommendations. 1.8% (95% CI: 1.7% to 2.0%) of all children and adolescents in the county district of Ostallgäu were tested positive for SARS CoV-2, incidence of PIMS-TS was 1.7% (95% CI: 0.9% to 3.1%) among SARS CoV-2 positive tested earlier. …”
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    Successful Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19 (PIMS-TS) with Split Doses of Immunoglobulin G and Estimation of PIMS-TS Incidence in a County District in Southern Germany
  5. 5545
    “…Understanding the prevalence of NAFLD/NASH and its variations is of paramount importance to develop strategies to implement public health policy.…”
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    Increasing prevalence of NAFLD/NASH among children, adolescents and young adults from 1990 to 2017: a population-based observational study
  6. 5546
    por Alharbi, Hamad, You, Sijia, Katz, Joseph
    Publicado 2021
    “…CONCLUSION: Taste and smell disturbances in COVID-19 are not anecdotal. It is paramount that oral and maxillofacial surgeons include taste and smell disturbances in the history and physical examination as these symptoms are suspicious of active COVID-19 infection. …”
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    Should anosmia and dysgeusia be a concern for oral and maxillofacial surgeons during the COVID-19 pandemic?
  7. 5547
    “…Finding effective ways to share the knowledge and insight between countries, including lessons learned, is paramount to the international containment and management of the COVID-19 pandemic. …”
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    Learning from public health and hospital resilience to the SARS-CoV-2 pandemic: protocol for a multiple case study (Brazil, Canada, China, France, Japan, and Mali)
  8. 5548
    “…PI NGS-MRD(−) patients had a significantly improved survival as compared to patients who became NGS-MRD(−) subsequently indicating that kinetics of NGS-MRD clearance was of paramount importance. NGS-MRD identified over 80% of cases identified by flow cytometry at PI time point whereas FCM identified 49.3% identified by NGS. …”
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    Clinical impact of panel-based error-corrected next generation sequencing versus flow cytometry to detect measurable residual disease (MRD) in acute myeloid leukemia (AML)
  9. 5549
    “…Therefore, deciphering the cellular program activated downstream this pathway has become of paramount importance for the development of innovative therapies. …”
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    Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia
  10. 5550
    “…Understanding the molecular determinants of such cooperation will be paramount to the design of future therapeutic approaches.…”
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    Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes
  11. 5551
    por Terunuma, Yuri, Mathis, Bryan J.
    Publicado 2021
    “…BACKGROUND: In an increasingly globalized world, legal protocols related to health care that are both effective and culturally sensitive are paramount in providing excellent quality of care as well as protection for physicians tasked with decision making. …”
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    Cultural sensitivity in brain death determination: a necessity in end-of-life decisions in Japan
  12. 5552
    “…Routine monitoring and evaluation to prevent emergence of resistant strains to current efficacious antimalarials remains paramount.…”
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    Malaria Perceptions among Medicine Vendors in Buea Community: An Assessment of Knowledge of Malaria and Conditions of Antimalarial Drug Dispensing
  13. 5553
    por Perkovich, Cynthia, Ward, David
    Publicado 2021
    “…We analyzed the growth and defense responses of 12 Quercus (oak) species from a well‐resolved molecular phylogeny using phylogenetically independent contrasts. Access to light is paramount for forest‐dwelling tree species, such as many members of the genus Quercus. …”
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    Herbivore‐induced defenses are not under phylogenetic constraints in the genus Quercus (oak): Phylogenetic patterns of growth, defense, and storage
  14. 5554
    “…While pregnancy and motherhood have become paramount clinical issues for women living with HIV, parenting has received less attention among men living with HIV (MLWH). …”
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    Understanding the Importance of Fatherhood among Men Living with HIV in Ontario
  15. 5555
    “…Precise stereotactic targeting of the dorsolateral motor part of the subthalamic nucleus (STN) is paramount for maximizing clinical effectiveness and preventing side effects of deep brain stimulation (DBS) in patients with advanced Parkinson’s disease. …”
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    Targeting of the Subthalamic Nucleus in Patients with Parkinson’s Disease Undergoing Deep Brain Stimulation Surgery
  16. 5556
    “…Infected infants without structural brain anomalies also appear to have an increased risk, although to a lesser extent, of neurological abnormalities. It seems paramount to offer systematic testing for congenital ZIKV infection in cases of in utero exposure and adapt counseling based on these results.…”
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    Association between confirmed congenital Zika infection at birth and outcomes up to 3 years of life
  17. 5557
    “…Thus, rational design of efficient nanozymes remains a challenge of paramount importance. Different implementation paths have already been explored, including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase activities. …”
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    Gold Nanozymes: From Concept to Biomedical Applications
  18. 5558
    “…DISCUSSION: Elucidating whether dynamic LVOT obstruction is contributing to cardiogenic shock physiology is paramount since the management radically differs depending on the presence or absence of obstruction. …”
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    A case report of cardiogenic shock from takotsubo cardiomyopathy with left ventricular outflow tract obstruction: fundamental lessons in cardiac pathophysiology
  19. 5559
    “…African governments should develop flexible, iterative lockdown exit plans based on epidemiological disease data, economic indicators, and peoples' views to inform decisions, all of which are paramount for success. A phased approach of changes and willingness to adapt methods will allow governments to minimize the pandemic's adverse impact and respond accordingly as new control tools become available.…”
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    A proposed framework to limit post-lockdown community transmission of COVID-19 in Africa
  20. 5560
    por Reed, Jonathan D., Blackwell, Kim T.
    Publicado 2021
    “…Accurate neuron morphologies are paramount for computational model simulations of realistic neural responses. …”
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    Prediction of Neural Diameter From Morphology to Enable Accurate Simulation
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