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  1. 6741
    “…In addition to the development of curative new antifungal agents, understanding the barriers to patient adherence to care and antifungal therapy and identifying means to overcome such barriers are of paramount importance.…”
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    Challenges in the Long-term Management of Patients With Coccidioidal Meningitis: A Retrospective Analysis of Treatment and Outcomes
  2. 6742
    “…Nurses’ satisfaction and retention are paramount to providing safe, high-quality patient care. …”
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    The association of patient safety culture with intent to leave among Jordanian nurses: a cross-sectional study
  3. 6743
    “…Since, the accurate estimation of IFT is of paramount significance, modeling with advanced intelligent techniques has been used as a proper alternative in recent years. …”
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    Modeling interfacial tension of surfactant–hydrocarbon systems using robust tree-based machine learning algorithms
  4. 6744
    “…Accurate histopathological classification is paramount for the diagnosis and adequate treatment of the disease. …”
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    Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis
  5. 6745
    “…The identification of such an anatomical distribution is paramount for screening procedures, early detection of disease, and prevention of complications, particularly limb amputation.…”
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    Anatomical Distribution Patterns of Peripheral Arterial Disease According to Patient Characteristics: A Unicentral Cohort Study
  6. 6746
    “…BACKGROUND: Segmental fusion operations assume paramount significance for individuals afflicted by full layers of annulus tears as they avert the perils of rapid disc degeneration and segmental instability. …”
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    Nucleus high intensity in the T2-weighted MRI is a potential predictor of annulus tear in cervical injured patients: a case comparative study
  7. 6747
    “…This year, the Melanoma Bridge Congress (Dec 1(st)–3rd, 2022, Naples, Italy) addressed the latest advances in melanoma research, focusing on themes of paramount importance for melanoma prevention, diagnosis and treatment. …”
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    Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 1st–3rd, 2022—Naples, Italy)
  8. 6748
    “…BACKGROUND: Glioblastoma growth impacts on the structure and physiology of peritumoral neuronal networks, altering the activity of pyramidal neurons which drives further tumor progression. It is therefore of paramount importance to identify glioma-induced changes in pyramidal neurons, since they represent a key therapeutic target. …”
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    Molecular changes underlying decay of sensory responses and enhanced seizure propensity in peritumoral neurons
  9. 6749
    “…In the context of the current global antimicrobial resistance crisis, understanding the adaptive and physiological responses of bacteria to antimicrobials is of paramount importance along with the development of new therapies. …”
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    Fierce poison to others: the phenomenon of bacterial dependence on antibiotics
  10. 6750
    “…As such, it will be paramount for this teenager to be closely monitored for signs of diminished kidney function and to be co-managed as he transitions to adult care to ensure proper treatment and management. …”
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    Dual diagnosis of autosomal dominant polycystic kidney disease and sickle cell disease in a teenage male
  11. 6751
    “…Concerning the health outcomes of intermittent fasting in Ramadan, loss of fat-free mass (FFM) and changes in the content of body water are of paramount importance. In this study, we aimed to assess the concomitant alterations in body water compartment and composition following Ramadan fasting in healthy individuals. …”
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    Alteration in body water compartments following intermittent fasting in Ramadan
  12. 6752
    “…Importance of alleviating fear of needle injection phobia amongst patients is of paramount importance. Ethyl chloride was found to be more effective than topical lidocaine in alleviating needle injection pain before administration of local anesthetic injection.…”
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    Cryoanesthesia with ethyl chloride spray versus 5% lidocaine gel in alleviating oral local anesthetic injection pain for buccal anaesthesia: A randomized clinical (controlled) trial
  13. 6753
    “…CONCLUSION: These recommendations guide clinicians in achieving timely and accurate diagnosis as well as providing optimal management, both of which are paramount to prevent loss of function and other devastating sequelae of infection in the knee joint. …”
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    ESSKA and EBJIS recommendations for the management of infections after anterior cruciate ligament reconstruction (ACL-R): prevention, surgical treatment and rehabilitation
  14. 6754
    “…Therefore, developing high-throughput animal models to screen for Pgp function and bioavailability of substrates and inhibitors is paramount. Here, we generated and validated a zebrafish knockout line of abcb4, a human Pgp transporter homolog. …”
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    Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein
  15. 6755
    “…Early-onset sepsis (EOS) is one of the leading causes of neonatal death and morbidity worldwide and timely initiation of antibiotic therapy is, therefore, of paramount importance. This study aimed to evaluate the predictive effect of lactate and base excess (BE) values in the cord arterial blood gas and the 6th hour of life venous blood gas analysis on clinical sepsis in newborns. …”
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    Evaluating of neonatal early onset sepsis through lactate and base excess monitoring
  16. 6756
    “…Understanding the penetrance of pathogenic variants identified as secondary findings (SFs) is of paramount importance with the growing availability of genetic testing. …”
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    The penetrance of rare variants in cardiomyopathy-associated genes: A cross-sectional approach to estimating penetrance for secondary findings
  17. 6757
    “…Therefore, detailed investigation of its real-life thermal stability in air is paramount for identification of potential risks and limitations during its high-temperature processing. …”
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    Thermal degradation of Affinisol HPMC: Optimum Processing Temperatures for Hot Melt Extrusion and 3D Printing
  18. 6758
    “…CONCLUSION: Pictogram-based instructions of medication orders were better understood by the Lebanese population than written instructions, making the incorporation of pictograms in pharmacy practice paramount to optimize medication use by the patient and thus yielding better health outcomes.…”
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    Comprehension of prescription orders with and without pictograms: tool validation and comparative assessment among a sample of participants from a developing country
  19. 6759
    “…Given the competitive nature of the residency match and shift in metrics emphasis after the change in STEP 1 scoring, early exposure to plastic surgery and mentoring relationships are paramount to applicant success. However, most medical students are not exposed to plastic surgery until they begin clinical rotations. …”
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    A Systematic Review of the State of Preclinical Mentorship Programs in Plastic and Reconstructive Surgery
  20. 6760
    “…An educational campaign that involves educating parents who consent for their child(ren) for HPVV, the children receiving the vaccination, and training staff providing HPVV through school-based immunization programs would be paramount.…”
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    Barriers to and facilitators of human papillomavirus vaccination in an ethnically diverse group of migrant parents: A qualitative mixed methods study
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