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  1. 7061
    “…Therefore, identification of cell lines with normal-like expression profiles is of paramount importance in studies of normal gene regulation. …”
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    PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes
  2. 7062
    “…BACKGROUND: Pulmonary pleomorphic carcinoma (PPC) is a rare type of lung cancer characterized by the poor response to conventional chemotherapy and subsequent disappointing outcomes. Therefore, it is paramount to delineate the molecular characteristics of this disease entity. …”
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    Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy
  3. 7063
    “…Human observational studies like this one are paramount in guiding translation from experimental studies to clinical trials.…”
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    Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man
  4. 7064
    “…To gain more insight in e.g. effectiveness of common therapies for different patient populations with similar clinical characteristics, consensus regarding the choice and use of outcome measures is paramount. To guide this choice, an overview of available instruments is necessary. …”
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    Online Artículo Texto
    Valid and reliable instruments for arm-hand assessment at ICF activity level in persons with hemiplegia: a systematic review
  5. 7065
    “…Regulation of cell growth is paramount to all living organisms. In plants, algae and fungi, regulation of expansive growth of cells is required for development and morphogenesis. …”
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    Stiff Mutant Genes of Phycomyces Affect Turgor Pressure and Wall Mechanical Properties to Regulate Elongation Growth Rate
  6. 7066
    “…However, other goals were paramount: cost containment, quality improvement, and organization survival. …”
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    Online Artículo Texto
    Innovation in patient-centered care: lessons from a qualitative study of innovative health care organizations in Washington State
  7. 7067
    “…Impairments of hippocampal neurogenesis are thought to be a paramountly important mechanism underlying radiation-induced cognitive dysfunction. …”
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    Effects of expression level of DNA repair-related genes involved in the NHEJ pathway on radiation-induced cognitive impairment
  8. 7068
    “…Unlocking alternative epigenetic routes for cell immortalization will be paramount for understanding crucial events leading to cell transformation. …”
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    Online Artículo Texto
    Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization
  9. 7069
    “…While genetic decay may be the principal dynamic in the evolution of newly emergent Y chromosomes, wholesale renovation is the paramount theme in the ongoing evolution of chimpanzee, human, and perhaps other older MSYs.…”
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    Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
  10. 7070
    “…Surveillance of hypogonadism and the bone mineral density levels followed by appropriate treatment may be of paramount importance to reduce the risk of osteoporosis development and prevention of fractures in this group of patients.…”
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    Hypogonadism and low bone mineral density in patients on long-term intrathecal opioid delivery therapy
  11. 7071
    “…Glutamate transport through astrocytic excitatory amino-acid transporters (EAAT)-1 and EAAT-2 is paramount for neural homeostasis. EAAT-1 has been reported in secreted extracellular microvesicles (eMV, such as exosomes) and because the protein kinase C (PKC) family controls the sub-cellular distribution of EAATs, we have explored whether PKCs drive EAATs into eMV. …”
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    Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation
  12. 7072
    “…CONTEXT: Microbial control is of paramount importance in Clinical Endodontics. Therefore, cleaning and disinfection of root canals are essential to achieve endodontic success. …”
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    Comparative evaluation of debris removal from root canal wall by using EndoVac and conventional needle irrigation: An in vitro study
  13. 7073
    “…Survival strategies exploited by parasites, including heme homeostasis mechanism in hemoparasites, are paramount for successful parasitism. Thus, assessing prospects for application in disease intervention is warranted.…”
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    Characterization of a Gene Family Encoding SEA (Sea-urchin Sperm Protein, Enterokinase and Agrin)-Domain Proteins with Lectin-Like and Heme-Binding Properties from Schistosoma japonicum
  14. 7074
    “…Beyond mortality and morbidity, the assessment of HrQoL is of paramount importance not only to guide patient-centered clinical decision-making but also to judge this new treatment modality. …”
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    Online Artículo Texto
    Beyond Adding Years to Life: Health-related Quality-of-life and Functional Outcomes in Patients with Severe Aortic Valve Stenosis at High Surgical Risk Undergoing Transcatheter Aortic Valve Replacement
  15. 7075
    “…BACKGROUND: Monitoring mortality and morbidity attributable to malaria is paramount to achieve elimination of malaria. Diagnosis of malaria is challenging and PCR is a reliable method for identifying malaria with high sensitivity. …”
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    PCR targeting Plasmodium mitochondrial genome of DNA extracted from dried blood on filter paper compared to whole blood
  16. 7076
    “…To prevent progression to limb gangrene, prompt diagnosis and treatment initiation are paramount. Here we report a rare case of posttraumatic phlegmasia cerulea dolens after ligation of the iliac vein to save the patient's life, with successful treatment by reconstructing the external iliac vein. …”
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    Successful treatment of posttraumatic phlegmasia cerulea dolens by reconstructing the external iliac vein: a case report
  17. 7077
    “…BACKGROUND: Infection-related exacerbations of respiratory diseases are a major health concern; thus understanding the mechanisms driving them is of paramount importance. Despite distinct inflammatory profiles and pathological differences, asthma and COPD share a common clinical facet: raised airway ATP levels. …”
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    Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD
  18. 7078
    “…BACKGROUND: Detection of molecular tumor heterogeneity has become of paramount importance with the advent of targeted therapies. …”
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    Reporting Tumor Molecular Heterogeneity in Histopathological Diagnosis
  19. 7079
    “…Knowledge of pathogen distribution is paramount for optimal patient management. METHODS: Microbiologically defined infections (MDI) in pediatric cancer patients presenting with FN by nonmyeloablative chemotherapy enrolled in a prospective multicenter study were analyzed. …”
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    A Prospective Multicenter Study of Microbiologically Defined Infections in Pediatric Cancer Patients With Fever and Neutropenia: Swiss Pediatric Oncology Group 2003 Fever and Neutropenia Study
  20. 7080
    “…Consequently, the isolation, culture and phenotypic characterization of SGECs are of paramount importance. In the present study study, human sweat glands were isolated by pipetting under a phase contrast microscope following digestion with collagenase type I. …”
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    Isolation, culture and phenotypic characterization of human sweat gland epithelial cells
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