“…For long-term clinical success, accurate design of both tooth preparation and ceramic veneers is of paramount importance. The aims of this in vitro study were to assess the stress in anterior teeth restored with Computer-Aided Design (CAD) and Computer-Aided Manufacturing (CAM) ceramic veneers and compare the resistance to detachment and the fracture of ceramic veneers prepared using two different designs. (2) Methods: Sixteen lithium disilicate ceramic veneers were designed and milled using the CAD-CAM technology and divided into two groups according to the preparations (n = 8): Group 1, conventional (CO), with linear marginal contour and Group 2, crenelated (CR), the latter with our novel (patented) sinusoidal marginal design. …”
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“…SIMPLE SUMMARY: Improving the reproductive performance of sows is a paramount goal in breeding programs. The number of teats is significantly associated with the reproductive performance of sows, with quantitative trait loci (QTL) related to porcine papilla number traits identified across almost all chromosomes, and with candidate genes proposed. …”
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“…SIMPLE SUMMARY: The early detection of behavioural changes based on variations in dairy cows’ daily routines is of paramount importance to the timely identification of the onset of disease. …”
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“…Thus, developing new analgesics is paramount for improving the health of people suffering from chronic pain. …”
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“…BACKGROUND: Healthy and predictable physiologic homeostasis is paramount in animal models for biomedical research. …”
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“…Infantile high-grade glioma should be regarded as a unique tumour entity and a multidisciplinary approach is paramount in improving survival for this group of patients.…”
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“…To enhance timely and targeted deployment of tsetse control strategies a better understanding of their temporal dynamics is paramount. A few empirical studies have explained and predicted tsetse numbers across space and time, but the resulting models may not easily scale to other areas. …”
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“…New ophthalmological tools, arguably the most important being optical coherence tomography (OCT), could prove paramount in redefining MS diagnoses and shaping their follow-up protocols, even when the optic nerve is not involved. …”
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“…Overcoming these challenges is of paramount significance and interdisciplinary approaches and innovative strategies are prevalently applied to optimize phytoconstituents’ production, enhance yield, biomass, ensure sustainable consistency and scalability. …”
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“…The development of high-performance insulation materials that facilitate the reduction in building energy consumption is of paramount significance. In this study, magnesium–aluminum-layered hydroxide (LDH) was prepared by the classical hydrothermal reaction. …”
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“…The quest for a cost-effective, chemically-inert, robust and proton conducting membrane for flow batteries is at its paramount. Perfluorinated membranes suffer severe electrolyte diffusion, whereas conductivity and dimensional stability in engineered thermoplastics depend on the degree of functionalization. …”
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“…Ensuring the safety of human–robot interaction (HRI) is paramount for effective collaboration. To achieve this, it is essential to have a reliable dynamic model of the cobot that enables the implementation of torque control strategies. …”
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“…The application of immunohistochemistry (IHC) for molecular characterization of breast cancer (BC) is of paramount importance; however, it is not universally standardized, subject to observer variability and quantifying is a challenge. …”
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“…Therefore, it is of paramount importance to develop and validate biomarkers that can be employed for the prediction, diagnosis and prognosis of LC and its therapeutic response, although this effort may be hampered by challenges pertaining to the non-specific nature of the majority of clinical manifestations in the LC spectrum, small sample sizes of relevant studies and other methodological issues. …”
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“…The pandemic has shown that developing a comprehensive infrastructure to overcome the loss of educational opportunities is of paramount importance to alleviate stress and anxiety among trainees.…”
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“…Collectively, these findings enabled us to define the optimal conditions inside the bioreactor for an efficient in vitro cell organization and survival in spheroids, which are paramount to future applications with organoids.…”
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“…Thus, the establishment of specific diagnostic criteria and uniform protocols for the management of this common biochemical disorder is of paramount importance as it will hopefully allow for the early identification of infants at risk, the establishment of efficient preventive measures, the optimal treatment in the first hours of a neonate’s life and, subsequently, the improvement of neonatal outcomes.…”
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“…Creating a supportive and healthy work environment is thus of paramount importance in order to foster employees’ SWB. …”
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“…Outcomes after cardiac surgery are not only dependent on how the surgery went and how the anesthesia care was provided intraoperatively but also on the optimal management in the postoperative critical care setting. It is of paramount importance that the cardiac intensivist has a comprehensive understanding of cardiopulmonary physiology and the sequelae of cardiopulmonary bypass. …”
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“…It is urgent that this reflection takes place, as it is of paramount importance that what we all have lived in the past years serves as a lesson, and not as a warning of a crisis doomed to repeat itself. …”
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