“…Among them, histone ubiquitination appears relevant in nuclear processes that govern gene silencing, either by inhibiting or activating transcription, and maintain genome stability, acting as scaffold to properly organize the DNA damage response. Thus, it is of paramount importance the identification and the characterization of new ubiquitin ligases that address histones. …”
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“…This system will be of paramount importance to further our understanding of processes associated with the developmental origins of adult metabolic disease.…”
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“…BACKGROUND: Providing a secured airway is of paramount importance in cardiopulmonary resuscitation. …”
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“…Today, the disinfectant effect is calculated in terms of logarithmic reduction factors for the microbial count: a reduction of 5 log levels has been agreed, i.e. an inactivation kinetics of 99.999%. Of paramount importance was, in particular, the insight that different methods had to be employed to test disinfectants, while doing so not only in the laboratory but also under everyday working conditions. …”
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“…The need for additional and continuous training for nurses employed in fertility settings in Kuwait is paramount.…”
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“…Consequently, it is of paramount importance to have a method which is able to reliably and efficiently differentiate the numerous Vibrio species. …”
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“…BACKGROUND: Increasing evidence shows that good compliance with occlusion therapy is paramount for successful amblyopia therapy. PURPOSE: To study the degree of compliance and explore factors affecting compliance in patients undergoing occlusion therapy for amblyopia in our practice. …”
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“…Such a method can for example be used to construct a likelihood function, which is paramount for structure determination based on statistical inference. …”
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“…BACKGROUND: The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. …”
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“…BACKGROUND: Identification of broad neutralization epitopes in HIV-1 envelope spikes is paramount for HIV-1 vaccine development. A few broad neutralization epitopes identified so far are present on the surface of native HIV-1 envelope spikes whose recognition by antibodies does not depend on conformational changes of the envelope spikes. …”
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“…Accurate blood glucose measurement under extreme conditions is paramount for safe recreation at altitude. Prior studies reported bias in blood glucose measurements using different BGMs at high altitude. …”
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“…The results show that using the CPA significantly improves the accuracy of allele frequency estimates; moreover, this paramount factor is insensitive to the time of data acquisition, effect of laboratory site, type of gene chip, and phenotypic status. …”
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“…CONCLUSIONS/SIGNIFICANCE: The present study is the first apoplast proteome investigation of plant seedlings in response to H(2)O(2) and may be of paramount importance for the understanding of the plant network to environmental stresses. …”
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“…Understanding the prevalence of infectious syndromes and health utilization practices is paramount to disease surveillance, public health planning, and health care system reform. …”
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“…A 1.1-kb SF-1-binding region was identified in the angiopoietin 2 (Ang2, ANGPT2) promoter in a highly repetitive region, and SF-1-dependent activation was confirmed in luciferase assays. Angiogenesis is paramount in adrenal development and tumorigenesis, but until now a direct link between SF-1 and vascular remodeling has not been established. …”
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“…INTRODUCTION: The accurate and reproducible assessment of cardiac volumes, function, and mass is of paramount importance in cardiology. In the present study we sought to determine whether the 3D cine-magnetic resonance (MR) technique, using the variable asymmetric sampling in time (VAST) approach, provided an accurate assessment of LV functional parameters when compared with the conventional 2D cine-MR technique. …”
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“…PURPOSE: Preservation of renal function is of paramount importance in patients with tumors in solitary kidneys. …”
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“…BACKGROUND: Alternative insecticides for the control of malaria and filarial vectors are of paramount need as resistance is increasing among classes of insecticides currently in use in the public health sector. …”
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“…Universal newborn hearing screening (UNHS) is of paramount importance for early identification and management of hearing impairment in children. …”
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“…Thus being able to assess the capacity building process is paramount in facilitating action in communities for social and health improvement. …”
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