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  1. 7981
    “…Accurate upfront selection and prescription of a P2Y(12)I based on ischemic and bleeding risks is paramount to avoid adverse events switching-related during hospitalization and in the first 30 days.…”
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    Short term outcome following acute phase switch among P2Y(12) inhibitors in patients presenting with acute coronary syndrome treated with PCI: A systematic review and meta-analysis including 22,500 patients from 14 studies
  2. 7982
    “…The results from this early-phase RCT will further lay preliminary groundwork for ultimately providing clinicians and patients with guidelines for better using chronic treadmill walking exercise for improving cognition and brain health. This approach is paramount as learning and memory impairment is common, burdensome and poorly managed in MS. …”
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    Rationale and design of a single-blind, randomised controlled trial of exercise training for managing learning and memory impairment in persons with multiple sclerosis
  3. 7983
    “…Time-series analyses, often at monthly sampling frequencies, have established the paramount role of abiotic and biotic variables in structuring bacterioplankton communities and productivities. …”
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    High Frequency Multi-Year Variability in Baltic Sea Microbial Plankton Stocks and Activities
  4. 7984
    “…The key lessons concern issues of sustainability and the paramount importance of responsively shaping a context-driven RCB.…”
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    Context-led capacity building in time of crisis: fostering non-communicable diseases (NCD) research skills in the Mediterranean Middle East and North Africa
  5. 7985
    “…CONCLUSION: dDD is of paramount importance for early institution of targeted therapy and is considered as one of the key stewardship intervention. …”
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    Evaluation of performance of direct disk diffusion test from positively flagged blood culture broth: A large scale study from South India
  6. 7986
    “…In the case of trypanosomatids, these proteins play a paramount role, as gene expression regulation is mostly posttranscriptional. …”
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    Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2
  7. 7987
    “…Comprehensive geriatric assessment is of paramount importance in this subset of patients.…”
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    Free Flaps for Advanced Oral Cancer in the “Older Old” and “Oldest Old”: A Retrospective Multi-Institutional Study
  8. 7988
    “…Several non-metals have been used experimentally for extending the TiO(2) photo-absorption to the visible region of the spectrum. It’s therefore of paramount importance to provide theoretical guidance to experiment about the kind of defects that are thermodynamically stable at a realistic condition (e.g. …”
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    Stability of non-metal dopants to tune the photo-absorption of TiO(2) at realistic temperatures and oxygen partial pressures: A hybrid DFT study
  9. 7989
    “…This is especially true for the blind and visually impaired, for which haptic estimation of distances is paramount but not systematically trained. We investigated whether a programmable tactile display, used autonomously, can improve distance discrimination ability in blind and severely visually impaired youngsters between 7 and 22 years-old. …”
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    Enhancing general spatial skills of young visually impaired people with a programmable distance discrimination training: a case control study
  10. 7990
    “…Further studies that elaborate temporal associations and find out explanations for the relationship between diabetes and Hepatitis C viral infections are of paramount importance.…”
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    Hepatitis B And Hepatitis C Viral Infections And Associated Factors Among Patients With Diabetes Visiting Gondar Referral Teaching Hospital, Northwest Ethiopia: A Comparative Cross-Sectional Study
  11. 7991
    “…BACKGROUND: Identification of the optimal treatment for a given patient is of paramount importance. This is of particular relevance in osteoarthritis (OA) because of the high prevalence of the disease, extensive heterogeneity of the disease, and need for long-term treatment. …”
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    Serum lysophosphatidylcholines to phosphatidylcholines ratio is associated with symptomatic responders to symptomatic drugs in knee osteoarthritis patients
  12. 7992
    “…Prenatal diagnosis is a paramount mandatory integral part of the follow up of pregnancies with VCM of the foetus in high-income setting. …”
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    Antenatal and postnatal diagnoses of visible congenital malformations in a sub-Saharan African setting: a prospective multicenter cohort study
  13. 7993
    “…Understanding the risks is paramount to implementing countermeasures.…”
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    Reduced physical activity in young and older adults: metabolic and musculoskeletal implications
  14. 7994
    “…INTRODUCTION: As the epidemic of non-communicable diseases (NCDs) is rapidly developing in low and middle-income countries (LMICs), the importance of local research capacity and the role of contextually relevant research in informing policy and practice is of paramount importance. In this regard, initiatives in research capacity strengthening (RCS) are very important. …”
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    A scoping review of non-communicable disease research capacity strengthening initiatives in low and middle-income countries
  15. 7995
    “…BACKGROUND: While Salmonella serotyping is of paramount importance for the disease intervention of salmonellosis, a fast and easy-to-operate molecular serotyping solution remains elusive. …”
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    Multiplex ligation reaction based on probe melting curve analysis: a pragmatic approach for the identification of 30 common Salmonella serovars
  16. 7996
    “…Therefore, delineation of features of NMOSD-associated SSM is of paramount importance. OBJECTIVE: Our study aimed to determine the demographic, clinical and radiological features of NMOSD-associated SSM, and compare those with NMOSD-associated longitudinally extensive transverse myelitis (LETM) and multiple sclerosis (MS)-associated SSM, respectively. …”
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    Short segment myelitis as the initial and only manifestation of aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorders
  17. 7997
    “…To cope with the toxicity of free heme, H. contortus needs to uptake and detoxify the heme, a process believed to be paramount for parasite survival. METHODS: A heme-responsive gene Hc-hrg-2 was identified which is the homologue of Ce-hrg-2. …”
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    Hc-hrg-2, a glutathione transferase gene, regulates heme homeostasis in the blood-feeding parasitic nematode Haemonchus contortus
  18. 7998
    “…Infiltration process, which plays a paramount role in irrigation and drainage systems design, groundwater recharge and contamination evaluation, flood and drought management etc. is often controlled by several factors, among which land use/land cover (LULC) and soil physical properties are the prime factors. …”
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    Assessing Variability of Infiltration Characteristics and Reliability of Infiltration Models in a Tropical Sub-humid Region of India
  19. 7999
    “…Further, they show that healthcare professional education and training remain paramount in order to provide NIPT counseling in a way that supports pregnant women and couples’ choice.…”
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    Implementation challenges for an ethical introduction of noninvasive prenatal testing: a qualitative study of healthcare professionals’ views from Lebanon and Quebec
  20. 8000
    “…Raising awareness as to how structural racism can influence PM initiatives is paramount to avoid that PM ends up reproducing the pre-existing health inequalities between different ethnoracial groups and contributing to the loss of trust in healthcare by minority groups. …”
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    Structural racism in precision medicine: leaving no one behind
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