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  1. 8021
    “…Monitoring of MM and/or muscle metabolism in HD patients is of paramount importance for timely detection of muscle loss and to intervene adequately. …”
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    Clinical and predictive value of simplified creatinine index used as muscle mass surrogate in end-stage kidney disease haemodialysis patients—results from the international MONitoring Dialysis Outcome initiative
  2. 8022
    “…Macrophage phenotypes in synovium from osteoarthritic and healthy joints are poorly characterized; however, comparative knowledge of their phenotypes during health and disease is paramount for developing targeted treatments. This study compared patterns of macrophage activation in healthy and osteoarthritic equine synovium and correlated histology with cytokine/chemokine profiles in synovial fluid. …”
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    Macrophage Activation in the Synovium of Healthy and Osteoarthritic Equine Joints
  3. 8023
    “…BACKGROUND: The safety of surgery during and after the coronavirus disease-2019 (COVID-19) pandemic is paramount. Early reports of excessive perioperative mortality in COVID-positive patients promoted the widespread avoidance of operations. …”
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    Safety of major reconstructive surgery during the peak of the COVID-19 pandemic in the United Kingdom and Ireland – multicentre national cohort study
  4. 8024
    “…BACKGROUND: Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). …”
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    Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation
  5. 8025
    “…Our data collectively suggests that CXCR4/STAT3/Slug axis is paramount for IR resistance of NSCLC cells, and can be regarded as a therapeutic target to enhance the IR sensitivity of this devastating cancer.…”
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    CXCR4 uses STAT3-mediated slug expression to maintain radioresistance of non-small cell lung cancer cells: emerges as a potential prognostic biomarker for lung cancer
  6. 8026
    “…Since the evaluation of bioinformatics pipelines is not straightforward, NGS demands effective strategies to analyze data that is of paramount relevance for decision making under a clinical scenario. …”
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    Set-theory based benchmarking of three different variant callers for targeted sequencing
  7. 8027
    “…Judicious resource allocation is paramount but difficult due to the unpredictable disease course. …”
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    ALLY in fighting COVID-19: magnitude of albumin decline and lymphopenia (ALLY) predict progression to critical disease
  8. 8028
    “…Management of ALK+ patients is drastically changed and deciphering the molecular biology underlying this disease during treatment is of paramount relevance. The bedrock of resistance to TKI is that, after the diagnosis, we face with a different disease that needs to be re-characterized through tissue or/and liquid biopsies. …”
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    Resistance to anaplastic lymphoma kinase inhibitors: knowing the enemy is half the battle won
  9. 8029
    “…This becomes especially paramount considering the fact that many countries worldwide have initiated their vaccination programs by first targeting the elderly and most vulnerable persons. …”
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    External validity of phase III trials on vaccines against SARS-CoV-2 to a middle-aged and elderly Western European population
  10. 8030
    “…BACKGROUND: Elucidation of lipid metabolism and accumulation mechanisms is of paramount importance to understanding obesity and unveiling therapeutic targets. …”
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    Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity
  11. 8031
    por Gupta, Dhiren, Dhingra, Sandeep
    Publicado 2021
    “…Distinguishing patients who are going to benefit from fluids from those who will not is of paramount importance as large amounts of fluids used conventionally based on surviving sepsis guidelines may be detrimental. …”
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    Electrocardiometry Fluid Responsiveness in Pediatric Septic Shock
  12. 8032
    “…As the question of whether our HCWs must risk themselves to treat COVID-19 patients does not have a uniform answer, working on predictors of potential unwillingness is of paramount importance.…”
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    Predictors of Health-Care Workers’ Unwillingness to Continue Working During the Peak of COVID-19 in Western Ethiopia: An Extended Parallel-Process Model Study
  13. 8033
    “…The conduits of life; the animal oviducts and human fallopian tubes are of paramount importance for reproduction in amniotes. …”
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    Mechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct
  14. 8034
    “…Rapid detection of tuberculosis (TB) infection is paramount to curb further transmission. The gold standard for this remains mycobacterial culture, however emerging evidence confirms the presence of differentially culturable tubercle bacteria (DCTB) in clinical specimens. …”
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    Detection of differentially culturable tubercle bacteria in sputum using mycobacterial culture filtrates
  15. 8035
    “…Open science (OS) is of paramount importance for the improvement of science worldwide and across research fields. …”
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    Where Do Early Career Researchers Stand on Open Science Practices? A Survey Within the Max Planck Society
  16. 8036
    por Donato, Giulio, Forti, Edoardo, Mutignani, Massimiliano, Laterra, Maria Antonella, Arese, Daniele, Coppola, Franco, Zaccari, Piera, Mariani, Alberto, Arcidiacono, Paolo Giorgio, Pigò, Flavia, Conigliaro, Rita, Costa, Deborah, Tringali, Alberto, Lavagna, Alessandro, Rocca, Rodolfo, Gabbiadini, Roberto, Fugazza, Alessandro, Repici, Alessandro, Fava, Giammarco, Marini, Francesco, Mosca, Piergiorgio, Urban, Flavia, Monica, Fabio, Crinò, Stefano Francesco, Gabbrielli, Armando, Blois, Matteo, Binda, Cecilia, Sbrancia, Monica, Fabbri, Carlo, Frego, Roberto, Dinelli, Marco, Imbesi, Venerina, Gambitta, Pietro, Balzarini, Marco, Segato, Sergio, Grazioli, Leonardo Minelli, Spada, Cristiano, Amato, Arnaldo, Venezia, Giovanna, Aragona, Giovanni, Rosa, Cesare, Alvisi, Costanza, Devani, Massimo, Manes, Gianpiero, Dell’Amico, Iginio, Gemme, Carlo, Reati, Raffaella, Auriemma, Francesco, Mangiavillano, Benedetto, Rodi, Marcello, Bertani, Helga, Mazzucco, Dario, Armellini, Elia, Cantù, Paolo, Penagini, Roberto, Occhipinti, Pietro
    Publicado 2021
    “…Appropriate triage and screening of patients and adherence to society recommendations are paramount.…”
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    A multicenter survey on endoscopic retrograde cholangiopancreatography during the COVID-19 pandemic in northern and central Italy
  17. 8037
    “…The management of ECMO patients is still a specialty care, and a systematic and hospital based approach requiring an ECMO team composed of multiple experienced individuals is paramount during a respiratory viral pandemic.…”
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    A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part I: System Planning and Care Teams
  18. 8038
    “…As our approaches to coronavirus disease 2019 continue to evolve, the decision of timing of intubation remains paramount. Although noninvasive ventilation may allow for delaying intubation, it is possible that there are downstream effects of delayed intubation that should be considered, including the potential for pulmonary vascular thrombosis and intussusceptive angiogenesis with delayed intubation.…”
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    Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes
  19. 8039
    “…Therefore, having knowledge and foresight about how a country might be able to contain the spread of COVID-19 will be of paramount importance to the government, policy makers, business partners and entrepreneurs. …”
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    Forecasting the spread of COVID-19 using LSTM network
  20. 8040
    “…BACKGROUND: Although the equitable distribution of diabetic retinopathy (DR) services across Ghana remains paramount, there is currently a poor understanding of nationwide DR treatment services. …”
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    Situational analysis of diabetic retinopathy treatment Services in Ghana
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