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  1. 821
    “…In the emerging field of tissue engineering, understanding the role of different levels of oxygen for normal cell function as well as control of complex signalling cascades is paramount to effectively build 3D tissues in vitro and their subsequent survival when implanted.…”
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    Evolution of oxygen utilization in multicellular organisms and implications for cell signalling in tissue engineering
  2. 822
    “…Reversal of remodeling is therefore of paramount therapeutic importance, and mechanisms responsible for airway remodeling are feasible therapeutic targets for asthma treatment. …”
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    Mechanisms of Remodeling in Asthmatic Airways
  3. 823
    “…Hence, potent platelet inhibition is of paramount importance in order to optimise outcomes of diabetic patients with acute coronary syndrome. …”
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    Increased Atherothrombotic Burden in Patients with Diabetes Mellitus and Acute Coronary Syndrome: A Review of Antiplatelet Therapy
  4. 824
    “…Currently, molecular diagnosis is of paramount importance not only for phenotype-genotype correlations, genetic and prenatal counseling, and prognosis and aspects of management, but also concerning the imminent availability of clinical trials and treatments.…”
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    Congenital Muscular Dystrophies: A Brief Review
  5. 825
    “…Nanotechnological applications are gaining paramount importance in addressing this question, and yielding some promising results. …”
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    Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
  6. 826
    por Shujaat, Adil, Bajwa, Abubakr A.
    Publicado 2012
    “…Moreover, sepsis can be complicated by myocardial dysfunction, and only half of the critically ill patients exhibit preload responsiveness. It is of paramount importance to accurately, safely, and rapidly determine and optimize preload during resuscitation. …”
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    Optimization of Preload in Severe Sepsis and Septic Shock
  7. 827
    “…Documentation of (suspected) spillage is paramount when evaluating the possibility of postoperative complications, even many years later.…”
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    Abdominal wall abscess containing gallstones as a late complication to laparoscopic cholecystectomy performed 17 years earlier
  8. 828
    “…Early diagnosis of spontaneous bladder rupture is of paramount importance, so it is essential to think about it in the differential diagnosis of acute abdomen.…”
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    Spontaneous Bladder Perforation in an Infant Neurogenic Bladder: Laparoscopic Management
  9. 829
    “…Such a test would be of paramount importance also for screening of asymptomatic carriers of the disease with the aim of increasing food, drugs, and blood-derived products safety. …”
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    TSE Diagnostics: Recent Advances in Immunoassaying Prions
  10. 830
    “…Adequate debridement of infected material is of paramount importance to prevent relapse. A history of dehiscence is associated with increased risk of relapse and recurrent dehiscence.…”
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    Recurrent Prosthetic Mitral Valve Dehiscence due to Infective Endocarditis: Discussion of Possible Causes
  11. 831
    por Marzouk, Ola, Schofield, John
    Publicado 2011
    “…Histopathological factors remain paramount in this respect. Factors such as tumor size, histological type and subtype, presence of signet ring morphology and the degree of differentiation as well as the presence of lymphovascular invasion and lymph node involvement are well known factors that influence outcome. …”
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    Review of Histopathological and Molecular Prognostic Features in Colorectal Cancer
  12. 832
    “…Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. …”
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    Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams
  13. 833
    “…However, despite their utility, knowledge regarding specific devices and the supporting data for their use is of paramount importance to patient's safety. In this review, number of commercially available EADs are discussed and the reported benefits and potential pitfalls are highlighted.…”
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    Extraglottic airway devices: A review
  14. 834
    “…Feature selection is of paramount importance for text-mining classifiers with high-dimensional features. …”
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    A Novel Feature Selection Strategy for Enhanced Biomedical Event Extraction Using the Turku System
  15. 835
    por Kamala, K. A., Ashok, L., Sujatha, G. P.
    Publicado 2014
    “…Factors such as patient's age, size and site of lesion and the proximity of lesion to vital structure are paramount in the determination of the therapeutic approach and surgical excision. …”
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    Cavernous hemangioma of the tongue: A rare case report
  16. 836
    “…The identification and characterisation of the genetic pathways involved are paramount to the understanding of how we age and the development of therapeutic strategies for combating age-related disease. …”
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    Modelling age-related metabolic disorders in the mouse
  17. 837
    “…Therefore, the careful monitoring of cardiovascular events is of paramount importance in the course of monoclonal antibody-based therapies. …”
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    Adverse cardiac events to monoclonal antibodies used for cancer therapy: The risk of Kounis syndrome
  18. 838
    “…Furthermore, the critical selection of the appropriate case is of paramount importance to avoid the occurrence of such complications.…”
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    Development of pyogenic granuloma and hemangioma after placement of dental implants: A review of literature
  19. 839
    “…Going forward, the inclusion of individuals from this large and growing patient population in clinical trials will be of paramount importance.…”
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    Update on Hepatitis C Virus and HIV Coinfection
  20. 840
    “…Examination of glass slides is of paramount importance in pathology training. Until the introduction of digitized whole slide images that could be accessed through computer networks, the sharing of pathology slides was a major logistic issue in pathology education and practice. …”
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    Whole Slide Images and Digital Media in Pathology Education, Testing, and Practice: The Oklahoma Experience
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