“…Given vinorelbine is primarily hepatically metabolized, understanding its safety and pharmacokinetics in liver dysfunction remains paramount. In this phase I pilot study, weekly vinorelbine at doses ≥7.5 mg/m(2) is poorly tolerated in those with severe liver dysfunction. …”
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“…Accurate and rapid recognition of associated life-threatening conditions is paramount for timely treatment. Point-of-care ultrasound (POCUS) has been shown to impact the diagnosis of dyspnea presentations in resource-rich settings, and may be of greater diagnostic benefit in resource-limited settings. …”
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“…Thus, understanding the pitching mechanics of athletes pitching with upper extremity pain and those pain free is paramount. PURPOSE: To examine lower extremity pitching mechanics, upper extremity kinetics, and upper extremity pain in National Collegiate Athletic Association (NCAA) Division I female softball pitchers. …”
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“…Background: Choosing between deep brain stimulation (DBS), Levodopa-Carbidopa intestinal gel (LCIG), or continuous subcutaneous Apomorphine infusion (CSAI) in advanced Parkinson's disease is a complex decision. It is paramount to combine evidence with the professional's expertise and the patient's preferences. …”
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“…The rapid detection of resistance patterns is of paramount importance for establishing the proper antibiotic regime. …”
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“…CONCLUSIONS: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population.…”
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“…Establishing balanced nutrient requirements for maize (Zea mays L.) in the Northern Nigerian Savanna is paramount to develop site-specific fertilizer recommendations to increase maize yield, profits of farmers and avoid negative environmental impacts of fertilizer use. …”
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“…To overcome these obstacles, the development of appropriate drug delivery systems (DDS) for miRNAs is of paramount importance. METHODS: In this work, a triple combination of atomic force microscopy (AFM), brightfield (BF) and fluorescence microscopy was used to trace the cellular adhesion of N-TER peptide-nucleic acid complexes followed by time-dependent uptake studies using confocal laser scanning microscopy (cLSM). …”
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“…BACKGROUND: Identification of high resolving DNA-based markers is of paramount importance to unlock the potential of genetic diversity and selection of unique accessions of Capsicum annuum L., within Cross River and Ebonyi States of Nigeria, for breeding and conservation. …”
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“…BACKGROUND: As HIV has become a chronic condition, management of the disease and preventing resistance is paramount to improving patient outcomes. Medication errors can lead to suboptimal therapy and potential development of resistance. …”
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“…Implementing innovative, acceptable, and accessible screening practices and improving provider comfort with talking about sex are paramount to increasing rectal STI screening. [Image: see text] DISCLOSURES: All authors: No reported disclosures.…”
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“…Diagnosis of CDI is complicated when DNA amplification assay will return positive for both colonization and active infection of C. difficile, so testing clinically symptomatic patients with at least 3 loose stools per day is paramount to obtaining accurate reporting rates and starting proper treatment for CDI. …”
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“…BACKGROUND: Voluntary control of fertility is of paramount importance to the modern society. But since the contraceptive methods available for women have their limitations such as urinary tract infections, allergies, cervical erosion and discomfort, a desperate need exists to develop safe methods. …”
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“…SIMPLE SUMMARY: High mortality and involuntary culling rates cause great economic losses to the dairy industry around the world, and the survival of dairy calves and replacement heifers is paramount in modern dairy breeding. However, little has been done to genetically improve mortality rates of dairy calves and replacement heifers in Chinese Holstein cattle. …”
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“…BACKGROUND: High-quality cardiopulmonary resuscitation (HQ-CPR) is of paramount importance to improve neurological outcomes of cardiac arrest (CA). …”
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“…The close coexistence between humans and animals makes the safety assurance of pet food paramount. Different unit operations are applied at the industry level to prevent and reduce the presence of physical, chemical, and biological hazards in pet food; through these operations and adequate implementation of good manufacturing practices, the safety of the finished product can be preserved. …”
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“…Here, the assessment of the clinical probability of PE is a paramount step in its diagnosis. Although clinical probability models (CPM) for PE are routinely used in emergency departments (EDs) of low-resource settings, few studies have cited their diagnostic performances in sub-Saharan Africa (SSA). …”
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“…Besides, strengthening of information, education, and communication (IEC) on the issue of diabetes and insulin self-administration using mass media (television/radio) plays paramount importance.…”
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“…Therefore, image guidance is paramount to successful spine SBRT. Conventional X-ray imaging and alignment to surrogate bony anatomy may be inadequate, whereas magnetic resonance imaging (MRI) directly visualizes the dose-limiting cord. …”
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“…To make the most appropriate choice, an understanding of how to recognise maternal critical illness is paramount. Using the modified early obstetric warning system score (MEOWS) for obstetric patients is a useful tool (1). …”
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