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  1. 9461
    “…BACKGROUND: Increasing the number of specialized human resources for health is paramount to attainment of the United Nations sustainable development goals. …”
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    Advances in training of the specialized human resources for health in Tanzania: the case of Muhimbili University of Health and Allied Sciences
  2. 9462
    “…DISCUSSION: The evaluation of the extended-release formulation of buprenorphine compared to the standard sublingual formulation in real-world VHA settings is of paramount importance in addressing the opioid epidemic. …”
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    Rationale, design and methods of VA-BRAVE: a randomized comparative effectiveness trial of two formulations of buprenorphine for treatment of opioid use disorder in veterans
  3. 9463
    “…Finally, relative potency (REP) was employed to confirm the involvement of mechanisms of action paramount to AMP5A activity. RESULTS: AMP5A inhibits the release of CXCL10 from both CL075- and CL307-activated PMA-differentiated THP-1 and peripheral blood mononuclear cells. …”
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    AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMC
  4. 9464
    “…Early detection and treatment of probable and confirmed sarcopenia is paramount to delay mobility disability. Using low handgrip strength cut-off points for the initial identification of sarcopenia according to the new European Working Group on Sarcopenia in Older People (EWGSOP2) guidelines may mask the presence of sarcopenia. …”
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    Should knee extension strength testing be implemented as a screening test for identifying probable and confirmed sarcopenia in older T2DM patients?
  5. 9465
    “…BACKGROUND: Caring for older persons has become a global necessity to ensure functional ability and healthy ageing. It is of paramount importance that standards of care are monitored, especially for older persons who live in long term care facilities (LTCF). …”
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    Standards and quality of care for older persons in long term care facilities: a scoping review
  6. 9466
    “…Therefore, intervention that focuses on the identified predictors could have a paramount effect to prolong time to death and reduce preterm mortality. …”
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    Survival status and predictors of mortality among preterm neonates admitted to neonatal intensive care unit of Addis Ababa public hospitals, Ethiopia, 2021. A prospective cohort study
  7. 9467
    “…Early detection and control of these IMS at points of entry (PoEs) are of paramount importance to slow down any possible establishment. …”
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    From a long-distance threat to the invasion front: a review of the invasive Aedes mosquito species in Belgium between 2007 and 2020
  8. 9468
    “…Consistent and accurate positioning of these systems is paramount to reduce surgical times, stabilize fractures effectively, and reduce complications. …”
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    Accuracy of guide wire placement for femoral neck stabilization using 3D printed drill guides
  9. 9469
    “…The spatio-temporal representation allows borrowing strength from data neighboring to forecast at the level of the square cell (12 km)(2), getting accurate predictions also at the county level, which is paramount to help optimise the real-time allocation of health care resources during an epidemic emergency.…”
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    A deep learning approach for Spatio-Temporal forecasting of new cases and new hospital admissions of COVID-19 spread in Reggio Emilia, Northern Italy
  10. 9470
    “…Proper cross-sectoral collaboration in antenatal care is paramount to delivering sufficient supportive care to these women. …”
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    Challenges in the cross-sectoral collaboration on vulnerable pregnant women: a qualitative study among Danish general practitioners
  11. 9471
    “…The anaerobic digestion microbiome is the fundamental biological system operating biogas upgrading and is paramount in power-to-gas conversion. Carbon dioxide (CO(2)) methanation is frequently performed by microbiota attached to solid supports generating biofilms. …”
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    Integrating metagenomic binning with flux balance analysis to unravel syntrophies in anaerobic CO(2) methanation
  12. 9472
    “…Functional enrichment analyses showed that numerous terms and pathways associated with invasion and metastasis were enriched in the high-risk group. KRT7, as the most paramount risk gene in the prognostic model, was significantly associated with a worse prognosis of PC in TCGA dataset and our own cohort. …”
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    Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer
  13. 9473
    “…BACKGROUND: The study of molecular processes regulating heat stress response in dairy cattle is paramount for developing mitigation strategies to improve heat tolerance and animal welfare. …”
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    Weighted single-step GWAS and RNA sequencing reveals key candidate genes associated with physiological indicators of heat stress in Holstein cattle
  14. 9474
    “…An ophthalmic assessment complemented with SD-OCT has paramount importance in all newly diagnosed acute leukemic patients.…”
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    Ophthalmic Manifestations of Newly Diagnosed Acute Leukemia Patients in a Tunisian Cohort
  15. 9475
    “…Supporting these patients is of paramount importance in the current pandemic situation, including supporting their health care professionals in a cost-effective and efficient management of long COVID-19. …”
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    An Artificial Intelligence–Driven Digital Health Solution to Support Clinical Management of Patients With Long COVID-19: Protocol for a Prospective Multicenter Observational Study
  16. 9476
    “…BACKGROUND: The management of risk factors in patients with high cardiovascular risk and its effectiveness is of paramount importance. Over the last decade, several studies have examined the achievement of cardiovascular risk factors’ target levels in Europe. …”
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    Cardiovascular risk management: the success of target level achievement in high- and very high-risk patients in Hungary
  17. 9477
    “…Elucidating this relationship is paramount to understand the mechanisms underlying the early deterioration of the system and an important step in assessing the suitability of these measures as early biomarkers of disease. …”
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    Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach
  18. 9478
    “…Thus, protective measures that could increase the community’s and women’s awareness about the consequences of various forms of violence, and women empowerment are paramount. Priorities in programs of gender-based violence prevention should involve women from rural residences, older age, and males who consume alcohol.…”
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    Intimate partner violence and associated factors among HIV positive women attending antiretroviral therapy clinics in Gondar city, Northwest Ethiopia
  19. 9479
    “…BACKGROUND: Evaluation of the extent of genetic variation within and between the populations of crop genetic resources are of paramount importance in any breeding program. An experiment aimed at assessing the extent of variation among barley lines and the degree of association between hordein polypeptide and agronomic traits was hence executed. …”
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    The association between hordein polypeptide banding and agronomic traits in partitioning genetic diversity in six-rowed Ethiopian barley lines (Hordeum vulgare L.)
  20. 9480
    “…PURPOSE: Radical resection is paramount for curative oncological surgery. Fluorescence-guided surgery (FGS) aids in intraoperative identification of tumor-positive resection margins. …”
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    Side-by-Side Comparison of uPAR-Targeting Optical Imaging Antibodies and Antibody Fragments for Fluorescence-Guided Surgery of Solid Tumors
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