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  1. 1081
    “…It is paramount that any child or adolescent with a suspected disorder of sex development (DSD) is assessed by an experienced clinician with adequate knowledge about the range of conditions associated with DSD. …”
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    UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development
  2. 1082
    por Muula, Adamson S.
    Publicado 2006
    “…While in the practice of medicine the interest of the patient is paramount, this does not suggest that the welfare of the physician should be neglected at all. …”
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    Medicine And Money: Friends Or Foe?
  3. 1083
    “…During the preparation of immunoconjugates by chemical synthesis, the choice of the hinge component joining the two building blocks is of paramount importance: the conjugate must remain stable in vivo but must afford efficient release of the toxic moiety when the target is reached. …”
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    Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components
  4. 1084
    por Kushima, Ryoji, Kim, Kyoung-Mee
    Publicado 2011
    “…The complexity of cyto-architectural features has been considered to be of paramount importance for the diagnosis of carcinoma in Japan, while breach of the basement membrane and invasion into the lamina propria has been considered the sine qua non of malignancy and hence a pre-requisite for the diagnosis of cancer in the West. …”
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    Interobserver Variation in the Diagnosis of Gastric Epithelial Dysplasia and Carcinoma between Two Pathologists in Japan and Korea
  5. 1085
    “…The completeness of the tumor resection is of paramount importance in avoiding tumor progression and malignant transformation, which are rare in cases of epileptogenic glioneuronal tumors. …”
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    Focal Epilepsy Associated with Glioneuronal Tumors
  6. 1086
    por Burgoyne, Joseph R., Eaton, Philip
    Publicado 2010
    “…The control of vascular smooth muscle contractility enables regulation of blood pressure, which is paramount in physiological adaptation to environmental challenges. …”
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    Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation
  7. 1087
    “…Hence, being able to efficiently store sequencing and resequencing data is a problem of paramount importance. In this article, we describe GReEn (Genome Resequencing Encoding), a tool for compressing genome resequencing data using a reference genome sequence. …”
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    GReEn: a tool for efficient compression of genome resequencing data
  8. 1088
    “…A number of procedure-related problems can be encountered and a thorough knowledge of these is of paramount importance. Penile prosthesis surgery has a favorable psychological outcome. …”
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    Three-piece Inflatable Penile Prosthesis: Surgical Techniques and Pitfalls
  9. 1089
    “…Thus, knowledge of orbital osteology is paramount in adequately choosing and performing an orbital approach. …”
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    Microsurgical Anatomy of the Orbit: The Rule of Seven
  10. 1090
    por AlMaatouq, Mohamed A
    Publicado 2012
    “…Individualization of care is paramount in this regard to take into consideration the patient and societal, cultural, and economic variables.…”
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    Pharmacological approaches to the management of type 2 diabetes in fasting adults during Ramadan
  11. 1091
    por Prinja, S
    Publicado 2010
    “…Consideration of this knowledge is paramount where more efforts are being made to bridge the gap between the ‘two worlds’ of researchers and policy makers to make evidence-based policy as also for policy analysts.…”
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    Role of Ideas and Ideologies in Evidence-Based Health Policy
  12. 1092
    “…We conclude that good surgical practice is paramount to reduce adhesion formation and that anti-adhesion agents may contribute to adhesion prevention in certain cases.…”
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    Prevention of adhesions in gynaecological surgery: the 2012 European field guideline
  13. 1093
    “…The development of methods for pathway inference from metagenomics data is of paramount importance to link a phenotype to a cascade of events stemming from a series of connected sets of genes or proteins. …”
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    Bioinformatic approaches for functional annotation and pathway inference in metagenomics data
  14. 1094
    “…Preservation of vision is of paramount importance. On follow-up patients should be monitored for complications and remedied.…”
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    Orbital tuberculosis manifesting as proptosis in an immunocompromised host
  15. 1095
    “…BACKGROUND: Induction of general anesthesia in a patient with compromised airway has always caused dilemma to anesthesiologist, especially for toddler this is paramounted. CASE PRESENTATION: An 18 month old boy had a huge sized lingual mass which not only filled entire oral cavity but protruded outside the mouth up to about 5 cm. …”
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    Airway Management in a Toddler with a Giant Hemangioma of the Tongue
  16. 1096
    “…Recognizing the possibility of invasive HCC causing upper GI haemorrhage is of paramount importance as acute management differs from the usual aetiologies. …”
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    A rare cause of gastrointestinal haemorrhage: gastric invasion by hepatocellular carcinoma
  17. 1097
    “…For explanatory trials in which internal validity is paramount, there is little room for variation of methods between the pilot and main trial. …”
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    Acceptance checklist for clinical effectiveness pilot trials: a systematic approach
  18. 1098
    “…If treatment with imatinib fails, further lines of TKI therapy have a role, but disease response is usually only measured in months, so strategies to maximize the benefit from imatinib are paramount. Here, we provide an overview of the structure and signaling of c-KIT coupled with a review of the clinical trials of imatinib in GIST. …”
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    Update on imatinib for gastrointestinal stromal tumors: duration of treatment
  19. 1099
    “…We show that one third of the mutants consisted of strains mutated in genes previously reported to be of paramount importance in starch catabolism such as those encoding β-amylases, the maltose export protein, and branching enzyme I. …”
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    A Forward Genetic Approach in Chlamydomonas reinhardtii as a Strategy for Exploring Starch Catabolism
  20. 1100
    “…In cases of metabolic pancreatitis, over and above the standard routine management of pancreatitis, careful management of the underlying metabolic abnormalities is of paramount importance. If not treated properly, it leads to recurrent life-threatening bouts of acute pancreatitis. …”
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    Metabolic pancreatitis: Etiopathogenesis and management
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