“…OUTCOMES: After 3 months of treatment with oral itraconazole, culture of the conjunctival secretions was negative. LESSONS: It is of paramount importance to clinically suspect mycosis, even in unusual locations or in the absence of the typical epidemiological history.…”
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“…The review concludes that achieving a sound understanding of local groundwater characteristics and human impact on groundwater resources across scales is paramount to implementing the sustainable development goals in an integrated manner.…”
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“…Our aim is to depict that deep knowledge of MCV anatomy and its variations is of paramount importance to achieve CME and to avoid dangerous or massive bleeding.…”
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“…The detection of the exact interface locations and the level changes for layered liquids are of paramount importance for chemistry purifications, liquid storage in reservoirs, oil transportation, and chemical engineering. …”
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“…As with other therapeutic areas, optimizing compound ADMET and PK properties in parallel with target inhibitory potency and whole cell activity becomes paramount toward advancing compounds as clinical candidates. …”
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“…CURRENT EVIDENCE SUMMARY: Because SDR is an irreversible procedure, careful patient selection, a multi-disciplinary approach in assessment and management and division of the appropriate proportion of dorsal rootlets are felt to be paramount for maximizing safety. Reliable evidence exists that SDR consistently reduces spasticity, in a predictable manner and to a substantial degree. …”
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“…Establishing synaptic contacts between neurons is paramount for nervous system function. This process involves transsynaptic interactions between a host of cell adhesion molecules that act in cooperation with the proteins of the extracellular matrix to specify uniquephysiological propertiesofindividual synaptic connections. …”
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“…Important new strategies to identify early biomarkers with predictive value to intervene with disease progression at stages where cell dysfunction has not progressed irreversibly is of paramount importance. Thus, the identification of these markers presents an essential opportunity to identify and target disease pathways. …”
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“…Awareness and knowledge of this entity are of paramount importance for clinical practitioners.…”
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“…Disease resistance is of paramount importance for both the control and the culture of mealworms, and several biotic and abiotic environmental factors affect the success of their anti-parasitic defenses, both positively and negatively. …”
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“…Therefore, a high degree of clinical suspicion is paramount for early diagnosis of this complication in UFE patients.…”
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“…The role of soil biota and particularly arbuscular mycorrhizal (AM) fungi in this new agriculture is believed to be of paramount importance. However, the large nutrient pools and the microbiota of subsoils are rarely considered in the equation. …”
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“…Multidisciplinary consensus on the diagnosis of CMI is of paramount importance to adequately select patients for treatment. …”
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“…Therefore, the understanding of the signaling pathways involved in stem cell pluripotency maintenance and differentiation has a paramount importance in order to understand these biological processes and to develop therapeutic strategies. …”
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“…A high index of suspicion with a low threshold for performing a native kidney biopsy would be paramount as patients do respond well to corticosteroid therapy.…”
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“…It serves as an exclusive model system where the spatial origin of energy transfer is exactly the same for both donating spin states involved. Of paramount significance are the facts that both transfers can easily be observed by eye and that Förster theory is successfully applied to state lifetimes spanning over 8 orders of magnitude.…”
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“…[Image: see text] Oxygen atom transfer reactions are receiving increasing attention because they bring about paramount transformations in the current biomass processing industry. …”
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“…The development of a greener, less expensive, and simpler method is paramount for the exploration of innovative compounds for application in medicinal and materials chemistry. …”
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“…Genetic alterations have been identified in around 20% of ASD patients and the use of genetic models, such as Drosophila melanogaster, has been of paramount importance in deciphering the significance of these alterations. …”
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“…One of the key factors for this improvement is a more favorable energy level alignment between donor and acceptor materials, which demonstrates that the properties of interfaces between donor and acceptor regions are of paramount importance. Recent investigations showed a significant dependence of the energy levels of organic semiconductors upon admixture of different materials, but its origin is presently not well understood. …”
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