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  1. 1261
    “…For these reasons, adequate and comprehensive management of CDI is of paramount importance in patients with IBD. Microbiological diagnosis, correct evaluation of clinical status, and consideration of different treatment options (from antibiotics and fecal microbiota transplantation to monoclonal antibodies) carry pivotal importance. …”
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    Risk Factors, Diagnosis, and Management of Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease
  2. 1262
    “…Preclinical in vivo studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal cancer. …”
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    Selecting an Appropriate Experimental Animal Model for Cholangiocarcinoma Research
  3. 1263
    “…Phosphorus (P) limitations to C uptake are paramount for tropical and subtropical forests around the globe. …”
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    Convergence in phosphorus constraints to photosynthesis in forests around the world
  4. 1264
    por Hasmath, Reza
    Publicado 2022
    “…In the long-term (three years plus), improving the relative socioeconomic ethnic inequalities is paramount.…”
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    Future Responses to Managing Muslim Ethnic Minorities in China: Lessons Learned from Global Approaches to Improving Inter-Ethnic Relations
  5. 1265
    “…Further knowledge in identifying, early diagnosing and adequate intervention in adolescents’ substance use disorder may have paramount prognostic features. DISCLOSURE: No significant relationships.…”
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    Substance use disorders in adolescence - a review
  6. 1266
    “…Lingual abscesses have the potential to develop into catastrophic obstructive airway issues; therefore, early detection and management are paramount. The following is a presentation of an elderly female with Bulbar Amyotrophic Lateral Sclerosis (ALS) treated conservatively for a lingual abscess with recurrence at eleven months post-treatment. …”
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    Recurrent Lingual Abscess in an Elderly Female With Bulbar Amyotrophic Lateral Sclerosis
  7. 1267
    por Puccini, Valentina
    Publicado 2022
    “…For this reason, tailoring a treatment plan for effective antibiotics that limit an athlete’s risk is paramount to their safety and ability to maintain adequate athletic performance. …”
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    Antibiotic Therapy and Athletes: Is the Mitochondrial Dysfunction the Real Achilles’ Heel?
  8. 1268
    por Espie, David, Donnadieu, Emmanuel
    Publicado 2022
    “…In this context, it is of paramount importance to understand the determinants that condition CAR T-cell success versus failure. …”
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    New insights into CAR T cell-mediated killing of tumor cells
  9. 1269
    por Adatia, Adil, Vliagoftis, Harissios
    Publicado 2022
    “…Patient selection has been paramount for the success of these biologicals, leading to significant interest in biomarkers to guide treatment. …”
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    Challenges in severe asthma: Do we need new drugs or new biomarkers?
  10. 1270
    “…Safety in delivery as well as caring for newborn and her mother is of paramount importance. Hence, clarity for Lotus delivery in any set up is indispensable. …”
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    “Do not detach the placenta from my baby's cord” - Lotus birth case series from Tanzania tertiary hospital
  11. 1271
    “…Therefore, providing a prompt and accurate diagnosis for PE through developing highly sensitive and specific diagnostic algorithms would be of paramount importance. There is sound evidence supporting the use of biomarkers to enhance the diagnosis and predict the recurrence risk in patients with PE. …”
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    Contemporary Biomarkers in Pulmonary Embolism Diagnosis: Moving beyond D-Dimers
  12. 1272
    “…Altogether, the results summarized below are of paramount importance in pediatric patients where a considerable proportion of treatments are prescribed off-label. …”
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    Off-label use of canakinumab in pediatric rheumatology and rare diseases
  13. 1273
    “…Imaging methodologies able to resolve the binding dynamics of translation factors at single-cell and single-mRNA resolution were necessary to fully elucidate regulation of this paramount process. Here live-cell spectroscopy and single-particle tracking were combined to interrogate the binding dynamics of endogenous initiation factors to the 5’cap. …”
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    Cap-dependent translation initiation monitored in living cells
  14. 1274
    “…Mitochondria are paramount to the metabolism and survival of cardiomyocytes. …”
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    Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure
  15. 1275
    “…Standardization of supportive care is paramount.…”
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    Supportive Care for Patients with Lymphoma Undergoing CAR-T-cell Therapy: the Advanced Practice Provider’s Perspective
  16. 1276
    “…Consequently, understanding the advantages and disadvantages of each valve and personalising the valve selection based on patient-specific clinical and anatomical characteristics is paramount. This review article aims to both analyse the available devices in the presence of specific clinical and anatomic features and offer guidance to select the most suitable valve for a given patient.…”
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    Personalised Treatment in Aortic Stenosis: A Patient-Tailored Transcatheter Aortic Valve Implantation Approach
  17. 1277
    por Doub, James B.
    Publicado 2022
    “…Therefore, diagnosis is difficult but paramount to thwart the morbidity and mortality associated with this infectious condition as well as to reduce the prolonged use of broad-spectrum antibiotics. …”
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    Use of α-Defensins to Help Diagnose Nosocomial Ventriculitis
  18. 1278
    “…Given the future likelihood of increased virtual teaching, it is of paramount importance to explore ways of enhancing the sociability of teaching courses. …”
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    The core trainee ‘residential’: an opportunity for trainees to feel connected in a world of virtual teaching
  19. 1279
    “…This reflection concluded that the obligations of both roles should be adhered to where possible, but if in doubt, the needs of the participants were paramount.…”
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    A Reflection on the Tensions of Acting in Dual Roles of Doctoral Researcher and Practitioner when Evaluating a Lifestyle Intervention for Breast Cancer Patients
  20. 1280
    “…Hence, timely diagnosis and initiation of treatment with corticosteroids, immunosuppressants, or tyrosine kinase inhibitors are of paramount importance. We present a case of ECD with multisystemic involvement, who was initially evaluated for the left lung mass and treated as tuberculosis, where fluorine-18-labeled fluorodeoxyglucose positron emission tomography/computed tomography aided in targeting the metabolically active site for biopsy as well as assessing the multisystemic involvement.…”
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    Utility of Fluorine-18-Labeled Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Diagnosis of Erdheim–Chester Disease with Multisystemic Involvement
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