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  1. 1341
    por Theodorson, Thord
    Publicado 1995
    “…The need for cardiovascular risk assessment to be multifactorial and made in terms of overall actual risk is of paramount importance. The implications of this overall issue for countries like those of the Middle East, where the prevalence of cardiovascular disease is on the rise, are of great concern.…”
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    Cardiovascular Risk and Risk Reduction: A Review of Recent Literature
  2. 1342
    “…Antimicrobial peptides (AMPs), including defensins and cathelicidins, constitute an arsenal of innate regulators of paramount importance in the gut. The intestinal epithelium is exposed to myriad of enteric pathogens and these endogenous peptides are essential to fend off microbes and protect against infections. …”
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    Intestinal antimicrobial peptides during homeostasis, infection, and disease
  3. 1343
    “…The DNA mismatch repair system (MMR) is highly conserved between species; its role is paramount in the preservation of DNA integrity, placing it as a necessary focal point in the study of pathways that prolong lifespan, aging, and disease. …”
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    DNA Mismatch Repair System: Repercussions in Cellular Homeostasis and Relationship with Aging
  4. 1344
    “…Vascular anomalies constitute some of the most difficult diagnostic and therapeutic enigmas in the head and neck region. It is of paramount importance that a modern classification system is established to differentiate vascular lesions from vascular malformations. …”
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    Low flow vascular malformation of the buccal mucosa treated conservatively by sclerotherapy (3% sodium tetradecyl sulfate)
  5. 1345
    “…The regulatory mechanism of dosage compensation is the paramount example of epigenetic regulation at the chromosomal level. …”
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    Distinct contributions of MSL complex subunits to the transcriptional enhancement responsible for dosage compensation in Drosophila
  6. 1346
    “…Trans-arterial radioembolization using yttrium-90 (Y90) microspheres is a possible treatment option. Paramount to its success is the meticulous angiographic interrogation of tumor feeding arteries and extra-hepatic supply. …”
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    Intra-Arterial CT Angiography Visualization of Arterial Supply to Inferior Vena Cava Tumor Thrombus Prior to Radioembolization of Hepatocellular Carcinoma
  7. 1347
    “…In such cases, surgical excision of the tumor without rupture is of paramount importance because rupture of the lesion can cause pseudomyxoma peritonei. …”
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    Two Cases of Mucinous Cystadenoma of the Appendix Successfully Treated by Laparoscopy
  8. 1348
    “…In the quest to miniaturise photonics, it is of paramount importance to control light at the nanoscale. …”
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    Gap plasmon-based metasurfaces for total control of reflected light
  9. 1349
    “…One area that has proved to be promising for such studies is the constituted by carbohydrates which participate in biological processes of paramount importance. On the one hand, carbohydrates have shown to be information carriers with similar, if not higher, importance than traditionally considered carriers as amino acids and nucleic acids. …”
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    Protein-Carbohydrate Interactions Studied by NMR: From Molecular Recognition to Drug Design
  10. 1350
    “…Therefore, a stringent regulation of Ikaros is of paramount importance for normal lymphocyte ontogeny. …”
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    Regulatory Phosphorylation of Ikaros by Bruton's Tyrosine Kinase
  11. 1351
    por Jiang, Luo-Luo, Perc, Matjaž
    Publicado 2013
    “…Interestingly, we find that between-group links are more likely to connect two cooperators than in-group links, thus supporting the conclusion that they are of paramount importance.…”
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    Spreading of cooperative behaviour across interdependent groups
  12. 1352
    “…Given the fact that efficient translation of valuable information embedded in brain scans into clinical application is of paramount scientific and public health importance, a strategy is needed to bridge the current gap between imaging and molecular biology, particularly in neurodegenerative diseases. …”
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    Biomarker-guided translation of brain imaging into disease pathway models
  13. 1353
    “…Since adult colonic intussusception is frequently associated with malignant organic lesions, the differential diagnosis is important, and timely surgical intervention paramount.…”
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    Submucosal lipoma acting as a leading point for colo-colic intussusception in an adult
  14. 1354
    “…Management of diabetic patients during surgical and critically illness is of paramount challenge to anesthesiologist and intensivist. …”
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    Hypoglycaemia in anesthesiology practice: Diagnostic, preventive, and management strategies
  15. 1355
    “…Increasing reliability is paramount. Outlier detection algorithms are a key component in screening latent defects and decreasing the number of customer quality incidents (CQIs). …”
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    Improving Electronic Sensor Reliability by Robust Outlier Screening
  16. 1356
    “…Therefore, a practical imaging approach based on the most sensitive and least invasive imaging modality in an efficient and cost-effective manner is paramount. We reviewed the conventional radiographs and computed tomography findings of the most common cystic and cavitary lung lesions in infants and children.…”
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    Cystic and Cavitary Lung Lesions in Children: Radiologic Findings with Pathologic Correlation
  17. 1357
    “…Controlling complex networks is of paramount importance in science and engineering. Despite the recent development of structural controllability theory, we continue to lack a framework to control undirected complex networks, especially given link weights. …”
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    Exact controllability of complex networks
  18. 1358
    “…Patient counseling regarding the pros and cons of anticoagulation is of paramount importance. Future prospective randomized studies should address the question regarding the utility of primary thromboprophylaxis in patients with nephrotic syndrome.…”
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    Primary Nephrotic Syndrome in Adults as a Risk Factor for Pulmonary Embolism: An Up-to-Date Review of the Literature
  19. 1359
    “…There is a very well known correlation between diabetes and cardiovascular disease but many health care professionals are just concerned with glycemic control, ignoring the paramount importance of controlling other risk factors involved in the pathogenesis of serious cardiovascular diseases. …”
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    Diabetes and cardiovascular disease: from evidence to clinical practice – position statement 2014 of Brazilian Diabetes Society
  20. 1360
    “…[Image: see text] The rational design of materials with tailored properties is of paramount importance for a wide variety of biological, medical, electronic and optical applications. …”
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    Surface Molecular Tailoring Using pH-Switchable Supramolecular Dendron-Ligand Assemblies
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