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  1. 1401
    “…Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to the mechanisms controlling cellular responses under such stress stimuli, are the transcription factor families of Hypoxia Inducible Factor (HIF) and Nuclear Factor of κ-light-chain-enhancer of activated B cells (NF-κB). …”
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    Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB
  2. 1402
    “…Total knee arthroplasty (TKA) is a surgical procedure of paramount relevance that restores a substantial degree of function in arthritic knees. …”
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    Patient-specific instrumentation in total knee arthroplasty. Should we adopt it?()
  3. 1403
    “…Nevertheless, despite of FROD’s high benefit-to-risk ratio, proper selection of patients based on meticulous preoperative assessment, including imaging, is of paramount importance to achieve optimal functional and aesthetic results. …”
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    Fat-removal orbital decompression for thyroid associated orbitopathy: The right procedure for the right patient
  4. 1404
    “…CONCLUSIONS: This case highlights the diagnostic defiance of rare tachycardia entities and the paramount importance of ECG documentation and analysis of all available tachycardia ECGs.…”
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    One symptom, two arrhythmias: the rare and the even rarer
  5. 1405
    por Vanbelle, Sophie
    Publicado 2017
    “…Reliability and agreement are two notions of paramount importance in medical and behavioral sciences. …”
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    Comparing dependent kappa coefficients obtained on multilevel data
  6. 1406
    “…The accurate assessment of immune competence through ex vivo analysis is paramount to our understanding of those immune mechanisms that lead to protection or susceptibility against a broad range of human pathogens. …”
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    Functional Analysis of Phagocyte Activity in Whole Blood from HIV/Tuberculosis-Infected Individuals Using a Novel Flow Cytometry-Based Assay
  7. 1407
    “…Billions of individuals are affected, and although diet and lifestyle are of paramount importance to the development of adult obesity, compelling evidence is emerging which suggests that maternal obesity and related disorders may be passed on to the next generation by non-genetic means. …”
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    The Molecular Mechanisms of Offspring Effects from Obese Pregnancy
  8. 1408
    “…Nuclear Pore Complex (NPC) is of paramount importance for cellular processes since it is the unique gateway for molecular exchange through the nucleus. …”
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    Nuclear pore complex plasticity during developmental process as revealed by super-resolution microscopy
  9. 1409
    “…Understanding the mechanisms of APP processing is therefore paramount. Increasing evidence suggests that APP intracellular domain (AICD) interacting proteins influence APP processing. …”
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    GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease
  10. 1410
    “…Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. …”
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    Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls
  11. 1411
    por Rostami‐Hodjegan, Amin
    Publicado 2017
    “…This review demonstrates the advantages of such strategies in filling knowledge gaps and discusses the perceived hurdles in widening applications. It is paramount that no clinical data are assessed on their own, but in conjunction with other studies for that drug in different populations and/or other similar drugs in the same population.…”
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    Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence
  12. 1412
    por Christen, Urs, Hintermann, Edith
    Publicado 2018
    “…Thus, an early and reliable diagnosis is paramount for the initiation of a proper therapy with immunosuppressive and/or anticholelithic drugs. …”
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    Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease?
  13. 1413
    “…In order to produce seasoned graduates from tertiary institutions, academic performance of students should be paramount in the minds of stakeholders. The dataset presented the perception of engineering students and lecturers in two private universities in Ogun state, namely, Bells University of Technology and Covenant University. …”
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    Survey dataset on the impact of stakeholder's relationship on the academic performance of engineering students
  14. 1414
    “…In this relationship, the different inherent parameters of physical activity-exercise (training volume, intensity, objective, organization and frequency) are of paramount importance. Therefore, this review discusses both the negative and positive impact of physical exercise on the male reproductive potential. …”
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    Impact of physical activity and exercise on male reproductive potential: a new assessment questionnaire
  15. 1415
    “…The results contribute to an improved understanding of the methane cycle that is paramount to understanding human interventions influencing Earth’s climate. …”
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    A biochemical framework for anaerobic oxidation of methane driven by Fe(III)-dependent respiration
  16. 1416
    por Tailly, Geert G.
    Publicado 2003
    “…Proper imaging strategy is of paramount importance in the diagnosis of acute flank pain and in the subsequent therapy planning once a ureteral stone is diagnosed. …”
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    Modern Approach to Ureteral Stones
  17. 1417
    “…CONCLUSION: Knowledge of the routes of the spread of dental infection to the vital structures and the urgent need for aggressive multidisciplinary management is paramount. Furthermore, awareness of the rising quack culture in developing nations needs to be increased.…”
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    Complication of an Odontogenic Infection to an Orbital Abscess: The Role of a Medical Fraudster (“Quack”)
  18. 1418
    “…Node stage (N stage) is of paramount importance for gastric cancer staging. Radiologically node status implies detection and characterization of suspect malignant lymph nodes. …”
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    Is Accurate N – Staging for Gastric Cancer Possible?
  19. 1419
    “…Identifying genes and mechanisms controlling root angle is therefore of paramount importance to plant breeding. Here we show that the actin-binding protein Rice Morphology Determinant (RMD) controls root growth angle by linking actin filaments and gravity-sensing organelles termed statoliths. …”
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    Rice actin binding protein RMD controls crown root angle in response to external phosphate
  20. 1420
    “…[Image: see text] Attaining capability of label-free optical characterization of tissues will offer methodological advancement and possibilities for early clinical detection, which is of paramount importance in treating patients under clinical setups, for example, cancer. …”
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    Label-Free Imaging and Optical Characterization of Tissues Based on Autofluorescence
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