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  1. 1521
    “…Consequently, the search for new therapeutic agents with high safety profiles and low side effects is of paramount importance. Several natural products have been investigated and proven to have antimalarial effects either in vivo or in vitro. …”
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    Botanical candidates from Saudi Arabian flora as potential therapeutics for Plasmodium infection
  2. 1522
    “…In particular, the wettability and the structuring of the ionic liquids at the interface are of paramount importance for all those applications exploiting ionic liquids tribological properties, their double layer organization at electrified interfaces, and interfacial chemical reactions. …”
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    Nanostructure Determines the Wettability of Gold Surfaces by Ionic Liquid Ultrathin Films
  3. 1523
    “…Gut microbiome alterations may play a paramount role in determining the clinical outcome of clinical COVID-19 with underlying comorbid conditions like T2D, cardiovascular disorders, obesity, etc. …”
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    SARS-CoV-2-Indigenous Microbiota Nexus: Does Gut Microbiota Contribute to Inflammation and Disease Severity in COVID-19?
  4. 1524
    “…Growing evidence suggests that n-3 and n-6 PUFAs are paramount for brain functions. They constitute crucial elements of cellular membranes, especially in the brain. …”
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    Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders
  5. 1525
    “…SUMMARY: The bariatric-metabolic physician’s role is paramount in delivering effective care to patients with obesity. …”
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    The Bariatric-Metabolic Physician’s Role in Managing Clinically Severe Obesity
  6. 1526
    “…The ER cannot be generated de novo, and thus its proper inheritance during cell division is paramount to the health and survival of the daughter cells. …”
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    Regulation of the early stages of endoplasmic reticulum inheritance during ER stress
  7. 1527
    “…Recognizing vaccine failure and appropriately isolating patients are of paramount importance.…”
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    Acute Demyelinating Encephalomyelitis Following Measles Infection Due to Vaccine Failure: A Case Report
  8. 1528
    “…This differentiation is paramount as the subtype of cutaneous lupus informs upon treatment, disease monitoring, and prognostication. …”
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    Cutaneous Manifestations of “Lupus”: Systemic Lupus Erythematosus and Beyond
  9. 1529
    “…To assist policymakers in making adequate decisions to stop the spread of the COVID-19 pandemic, accurate forecasting of the disease propagation is of paramount importance. This paper presents a deep learning approach to forecast the cumulative number of COVID-19 cases using bidirectional Long Short-Term Memory (Bi-LSTM) network applied to multivariate time series. …”
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    Predicting COVID-19 cases using bidirectional LSTM on multivariate time series
  10. 1530
    “…To study disease development, an inventory of an organ's cell types and understanding of physiologic function is paramount. Here, we performed single-cell RNA-sequencing to examine heterogeneity of murine pancreatic duct cells, pancreatobiliary cells, and intrapancreatic bile duct cells. …”
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    Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree
  11. 1531
    “…Therefor the need for novel and pioneering anti-COVID19 is of paramount importance. In this direction, computer-aided drug design constitutes a very promising antiviral approach for the discovery and analysis of drugs and molecules with biological activity against SARS-CoV2. …”
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    Mathematical Multidimensional Modelling and Structural Artificial Intelligence Pipelines Provide Insights for the Designing of Highly Specific AntiSARS-CoV2 Agents
  12. 1532
    “…Since the pre- and intraoperative diagnosis should guide surgical decision making, obtaining a sufficient specimen size to find representative material in the cell block is of paramount importance.…”
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    Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature
  13. 1533
    “…However, the hands-on anatomy laboratory experience is paramount to maximizing learning outcomes. In this paper, we share the experiences and lessons learned through the face-to-face cadaveric dissection experience during this disruptive situation. …”
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    Lessons from Cadaver Dissection during the COVID-19 Pandemic
  14. 1534
    “…Prompt recognition of this adverse effect is paramount to prevent disease progression and avoid permanent neurological damage.…”
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    Cefepime-Induced Delirium
  15. 1535
    “…A multidisciplinary approach commensurate with duration and severity of infection and tailored to the causative organism is paramount.…”
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    Chronic osteomyelitis caused by Achromobacter xylosoxidans following orthopaedic trauma: A case report and review of the literature()
  16. 1536
    “…Cooperation within and across borders is of paramount importance for the provision of public goods. …”
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    National parochialism is ubiquitous across 42 nations around the world
  17. 1537
    “…Close monitoring of these patients for recurrence is paramount. Evaluation of circulating tumor DNA (ctDNA) in the peripheral blood is an attractive approach due to its non-invasive nature. …”
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    Case Report: Circulating Tumor DNA Fraction Analysis Using Ultra-Low-Pass Whole-Genome Sequencing Correlates Response to Chemoradiation and Recurrence in Stage IV Small-Cell Carcinoma of the Cervix - A Longitudinal Study
  18. 1538
    “…The validation of protocols for carrying out the experimental analysis of amination reactions is of paramount importance to enhance the scientific knowledge and reproducibility of results. …”
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    Experimental protocol for the study of One-pot amination of Cyclohexanone-to-secondary amines over Carbon-supported Pd
  19. 1539
    “…Meticulous risk stratification is essential when considering intubation of a patient with decompensated pulmonary hypertension (dPH). It is paramount to understand both the pathophysiology of dPH (and associated right ventricular failure) and the complications related to a high-risk intubation before attempting the procedure. …”
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    Advanced airway management and respiratory care in decompensated pulmonary hypertension
  20. 1540
    “…As immunization campaigns are accelerating, understanding how to distribute the scarce doses of vaccines is of paramount importance and a quantitative analysis of the trade-offs involved in domestic-only versus cooperative distribution is still missing. …”
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    National interest may require distributing COVID-19 vaccines to other countries
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