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  1. 1601
    “…Understanding these alterations is paramount but hampered by limitations underlying cellular model systems. …”
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    Cell-specific bioorthogonal tagging of glycoproteins
  2. 1602
    “…The advancement of new promising techniques in the field of biomedical imaging has always been paramount for the research community. Recently, ultrasound tomography has proved to be a good candidate for non-invasive and safe diagnostics. …”
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    An Experimental Ultrasound System for Qualitative Tomographic Imaging
  3. 1603
    “…The increase of functional β-cell mass is paramount to maintaining glucose homeostasis in the setting of systemic insulin resistance and/or augmented metabolic load. …”
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    An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition
  4. 1604
    “…Therefore, managing comorbidities and limiting procedural complications, which may affect long-term outcomes, is of paramount importance. Among those, new-onset conduction disturbances and concomitant coronary artery disease remain two of the most debated issues. …”
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    Unmet Needs in TAVR: Conduction Disturbances and Management of Coronary Artery Disease
  5. 1605
    “…Crisis and disaster preparedness within a nation's health system is paramount to preventing disease spread. Various strategies for developing resilience in the face of global infectious disease spread were discussed. …”
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    Health system preparedness in infectious diseases: perspective of Malaysia, a middle-income country, in the face of monkeypox outbreaks
  6. 1606
    “…Plutonium oxide (PuO(2)) particularly plays a central role in nuclear energetics and a comprehensive knowledge about its properties when nanosizing is of paramount interest to understand its behaviour in environmental migration schemes but also for the development of advanced nuclear energy systems underway. …”
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    Synthesis and multi-scale properties of PuO(2) nanoparticles: recent advances and open questions
  7. 1607
    “…This discovery would be paramount for family planning and genetic counseling practices in families with affected individuals.…”
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    Case Report: Novel pathogenic variant in NFIX in two sisters with Malan syndrome due to germline mosaicism
  8. 1608
    “…With A. baumannii’s increasing resistance to most current antimicrobials, elucidating an effective host adaptive immune response is paramount in the guidance of future immunotherapeutic development.…”
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    Insights into Acinetobacter baumannii protective immunity
  9. 1609
    “…Therapeutics for transthyretin cardiomyopathy (ATTR-CM) are most effective when administered before significant symptoms of cardiac dysfunction manifest, making early identification of affected individuals of paramount importance. Community engagement and ensuring that a broad range of clinicians have working knowledge of how to screen for ATTR-CM in everyday practice will be an important step in moving disease identification further upstream. …”
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    Opportunities for Earlier Diagnosis and Treatment of Cardiac Amyloidosis
  10. 1610
    “…Innovative strategies to re-establish the immune-mediated destruction of malignant cells is paramount to the success of anti-cancer therapy. Accumulating evidence suggests that radiotherapy and select chemotherapeutic drugs and small molecule inhibitors induce immunogenic cell stress on tumors that results in improved immune recognition and targeting of the malignant cells. …”
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    Dying of Stress: Chemotherapy, Radiotherapy, and Small-Molecule Inhibitors in Immunogenic Cell Death and Immunogenic Modulation
  11. 1611
    “…These findings demonstrate the paramount importance of removing residual Pd, which was concluded to be more critical than optimization of a polymer’s molecular weight, to improve organic electrochemical transistor performance and that there is readily available improvement in performance and stability of many of the reported organic mixed ionic-electronic conductors.…”
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    The effect of residual palladium on the performance of organic electrochemical transistors
  12. 1612
    “…The results suggest that recruiting and retaining sufficient dedicated and motivated staff is paramount to ensuring quality of care from the managerial perspective, and it seems changes in the working culture may support quality of care in a cost-efficient way.…”
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    Managers’ Perspectives of Quality of Care in Service Housing and Home Care Services: A Qualitative Study
  13. 1613
    por Agbariah, Nada, Rovó, Alicia
    Publicado 2022
    “…A systematic diagnostic workup algorithm and a good anamnesis are of paramount relevance. More than one cause may be involved in the development of polycythemia, identifying all of them will be the key to better understanding and eventually solving the polycythemia. …”
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    Breaking Stereotypes: Polycythemia Secondary to Shisha Smoking in a Middle-Age Swiss Woman
  14. 1614
    “…A meticulous preoperative evaluation of the whole-body alignment, including the pelvis and lower extremities, is paramount to appreciate optimal GSA in the correction of spinal malalignment. …”
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    Reciprocal Changes Following Cervical Realignment Surgery
  15. 1615
    “…A multidisciplinary approach and understanding of the pathogenicity of cryptococcus and the immunological effect of thymic dysfunction are paramount to diagnosis and treatment.…”
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    Cutaneous cryptococcal infection: Initial manifestation of acquired T-cell immunodeficiency due to malignant thymoma
  16. 1616
    “…Early diagnosis and treatment are of paramount importance to prevent complications. Here, we report a case of traumatic bilateral anterior hip dislocation following a high-velocity motor vehicle accident. …”
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    Bilateral Traumatic Anterior Hip Dislocation – A Case Report
  17. 1617
    “…Use of multimodality imaging can be paramount to understanding anatomical and functional features of these complex vascular lesions, therefore optimizing success of potential curative interventions. …”
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    Percutaneous closure of giant aneurysmal coronary artery-to-coronary sinus fistulae with guidance from three-dimensional printed models: a case series
  18. 1618
    por Reis, João, Melão, Nuno
    Publicado 2023
    “…The need to deepen knowledge in digital transformation and refine the dimensions found is of paramount importance, as it involves some complexity due to organizational dynamics and the development of new technologies. …”
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    Digital transformation: A meta-review and guidelines for future research
  19. 1619
    “…The maximum impact was seen on patients with underlying cirrhosis who have shown to have poor clinical outcomes in the form of increased risk of hepatic decompensation, acute-on-chronic liver failure, and even mortality. It is of paramount importance to identify various factors which are associated with unfavorable outcomes for prognostication and making informed management strategy. …”
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    COVID-19 in patients with pre-existing chronic liver disease – predictors of outcomes
  20. 1620
    “…In order to enable the development of accurate treatment options, it is of paramount importance to fully understand post-burn immunology. …”
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    The Complexity of the Post-Burn Immune Response: An Overview of the Associated Local and Systemic Complications
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