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  1. 1661
    “…This is a significant concern given the alarming number of infections caused by multidrug-resistant microorganisms worldwide. Therefore, it is paramount to know the local epidemiology to propose tailored guidelines for empirical antibiotic selection in patients with cirrhosis in whom bacterial infections are suspected or confirmed. …”
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    Challenges and recommendations when selecting empirical antibiotics in patients with cirrhosis
  2. 1662
    “…Host‐guest interactions are of paramount importance in supramolecular chemistry and in a wide range of applications. …”
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    Unveiling the Collaborative Effect at the Cucurbit[8]uril‐MoS(2) Hybrid Interface for Electrochemical Melatonin Determination
  3. 1663
    “…Although the traditional pathological morphological classification of BC is of paramount importance and provides diagnostic and prognostic information, current interest focusses on the use of a single gene and multigene assays to stratify BC into distinct groups to guide decisions on systemic therapy. …”
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    An update on the pathological classification of breast cancer
  4. 1664
    “…We identify the origin of the homogeneous and inhomogeneous line shape of the simulated optical signals. This is paramount to decipher the spectroscopic nature of the ultrafast electron-transfer process occurring in organic photovoltaic (OPV) materials.…”
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    Modeling the Effect of Disorder in the Two-Dimensional Electronic Spectroscopy of Poly-3-hexyltiophene in an Organic Photovoltaic Blend: A Combined Quantum/Classical Approach
  5. 1665
    “…Laying the foundation for healthy behaviors is paramount during these formative years. The aim of this review is to determine which countries are leading in research on adolescents’ motivation towards physical activity and healthy habits and their main findings. …”
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    Motivation toward Physical Activity and Healthy Habits of Adolescents: A Systematic Review
  6. 1666
    “…Developing a better understanding of the roles of LAP1 and mutant TOR1AIP1-associated phenotypes is paramount to allow therapeutic development. To facilitate further studies, this review provides an overview of the known interactions of LAP1 and summarizes the evidence for the function of this protein in human health. …”
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    TOR1AIP1-Associated Nuclear Envelopathies
  7. 1667
    “…In medical malpractice, reconstruction of the pathological pathways is paramount. However, in cases of FIRS, ideal medical conduct is hard to delineate, due to uncertainty in diagnosis, treatment, and prognosis of this highly complex condition. …”
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    Infection Induced Fetal Inflammatory Response Syndrome (FIRS): State-of- the-Art and Medico-Legal Implications—A Narrative Review
  8. 1668
    “…Gaining knowledge on bees is of the utmost importance due to the paramount role that they play in angiosperm pollination. …”
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    The Whole Genome of Colletes collaris (Hymenoptera: Colletidae): An Important Step in Comparative Genomics of Cellophane Bees
  9. 1669
    “…Supervision is paramount within applied behavior analysis. This is particularly true in the case of Board Certified Behavior Analysts(®) (BCBAs(®)) and trainees (i.e., those accruing hours and experience to become BCBAs). …”
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    A Systematic Review of Supervision Research Related to Board Certified Behavior Analysts
  10. 1670
    “…When studying unknown human remains, the estimation of skeletal sex and ancestry is paramount to create the victim’s biological profile and attempt identification. …”
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    Comparing Genetic and Physical Anthropological Analyses for the Biological Profile of Unidentified and Identified Bodies in Milan
  11. 1671
    “…Understanding its underpinnings—and enhancing means of curbing vaccine hesitancy—will be paramount in boosting uptake in South Africa’s immunization program, particularly among youths.…”
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    COVID-19 Vaccination Hesitancy among Youths in Soweto, South Africa
  12. 1672
    por Rouan, Alice, Pousse, Melanie, Djerbi, Nadir, Porro, Barbara, Bourdin, Guillaume, Carradec, Quentin, Hume, Benjamin CC., Poulain, Julie, Lê-Hoang, Julie, Armstrong, Eric, Agostini, Sylvain, Salazar, Guillem, Ruscheweyh, Hans-Joachim, Aury, Jean-Marc, Paz-García, David A., McMinds, Ryan, Giraud-Panis, Marie-Josèphe, Deshuraud, Romane, Ottaviani, Alexandre, Morini, Lycia Die, Leone, Camille, Wurzer, Lia, Tran, Jessica, Zoccola, Didier, Pey, Alexis, Moulin, Clémentine, Boissin, Emilie, Iwankow, Guillaume, Romac, Sarah, de Vargas, Colomban, Banaigs, Bernard, Boss, Emmanuel, Bowler, Chris, Douville, Eric, Flores, Michel, Reynaud, Stéphanie, Thomas, Olivier P., Troublé, Romain, Thurber, Rebecca Vega, Planes, Serge, Allemand, Denis, Pesant, Stephane, Galand, Pierre E., Wincker, Patrick, Sunagawa, Shinichi, Röttinger, Eric, Furla, Paola, Voolstra, Christian R., Forcioli, Didier, Lombard, Fabien, Gilson, Eric
    Publicado 2023
    “…We propose that environmentally regulated mechanisms of telomere maintenance are linked to organismal performances, a matter of paramount importance considering the effects of climate change on health.…”
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    Telomere DNA length regulation is influenced by seasonal temperature differences in short-lived but not in long-lived reef-building corals
  13. 1673
    “…Sensitive and anti-interference detection of targeted signal(s) in body fluids is one of the paramount tasks in biosensing. Overcoming the complication and high cost of antibody/aptamer-modification, surface-enhanced Raman spectroscopy (SERS) based on antibody/aptamer-free (AAF) substrates has shown great promise, yet with rather limited detection sensitivity. …”
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    Antibody- and aptamer-free SERS substrate for ultrasensitive and anti-interference detection of SARS-CoV-2 spike protein in untreated saliva
  14. 1674
    “…Mimicking bone extracellular matrix (ECM) is paramount to develop novel biomaterials for bone tissue engineering. …”
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    Protease-degradable hydrogels with multifunctional biomimetic peptides for bone tissue engineering
  15. 1675
    “…Brain subcortical structures are paramount in many cognitive functions and their aberrations during infancy are predisposed to various neurodevelopmental and neuropsychiatric disorders, making it highly essential to characterize the early subcortical normative growth patterns. …”
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    Four-dimensional mapping of dynamic longitudinal brain subcortical development and early learning functions in infants
  16. 1676
    “…Yet, attempted diagnosis and prompt pharmacological intervention are paramount to improve outcomes.…”
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    Tuberculosis Presenting as Chronic Monoarthritis: A Case Study
  17. 1677
    “…High suspicion of an underlying neoplastic lesion in atypical brain hemorrhage in trauma patients is paramount. Short MRI follow-up is recommended as soon as the hematoma resorbs to prevent delays with potential impact or patient outcome.…”
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    Atypical Presentation of a Hemorrhagic Glioblastoma Multiforme Mimicking a Cerebral Contusion
  18. 1678
    “…Moreover, several studies have indicated that persisters may promote the evolution of antimicrobial resistance and facilitate the selection of specific resistant mutants; therefore, in light of the increasing numbers of multidrug-resistant infections worldwide, developing efficient strategies against dormant cells is of paramount importance. In this review, we present and discuss the efficacy of various agents whose antimicrobial activity is independent of the metabolic status of the bacteria as they target cell envelope structures. …”
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    New Strategies to Kill Metabolically-Dormant Cells Directly Bypassing the Need for Active Cellular Processes
  19. 1679
    “…Identification of the etiology after establishing the diagnosis of ischemic stroke is paramount for prognostication and treatment decisions. …”
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    Focal cerebral arteriopathy-inflammatory type in a child – MR diagnosis using vessel wall imaging technique with review of classification and diagnostic evaluation criteria
  20. 1680
    “…This study focuses on the high-precision detection of tomato diseases, which is of paramount importance for agricultural economic benefits and food safety. …”
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    High-Precision Tomato Disease Detection Using NanoSegmenter Based on Transformer and Lightweighting
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