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  1. 1801
    por Wang, Minjun, Tang, Wenbo, Zhu, Yi Zhun
    Publicado 2017
    “…Adenosine 5′-monophosphate-activated protein kinase (AMPK) plays a paramount role in maintaining cellular energetic balance. …”
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    An Update on AMPK in Hydrogen Sulfide Pharmacology
  2. 1802
    por Grimm, Amandine, Eckert, Anne
    Publicado 2017
    “…Mitochondria were placed at the center of the ‘free‐radical theory of aging’, because these paramount organelles are not only the main producers of energy in the cells, but also to main source of reactive oxygen species. …”
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    Brain aging and neurodegeneration: from a mitochondrial point of view
  3. 1803
    “…For successful FAIM, several design principles have to be considered and a thorough system-specific calibration protocol is paramount. One important calibration parameter is the G factor, which describes the system-induced errors for different polarization states of light. …”
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    Total internal reflection fluorescence anisotropy imaging microscopy: setup, calibration, and data processing for protein polymerization measurements in living cells
  4. 1804
    por Kim, Ah Ram, Sankaran, Vijay G
    Publicado 2017
    “…Importantly, this study, in tandem with other recent ones, shows that this rare genetic form of aplastic anemia is treatable with THPO receptor agonists, emphasizing the paramount role of genetic testing in cases of aplastic anemia and other bone marrow failure disorders. …”
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    Thrombopoietin: tickling the HSC's fancy
  5. 1805
    “…Broadening the participation of women in science, technology, engineering, and mathematical (STEM) fields is more than a social-justice issue; diversity is paramount to a thriving national research agenda. However, women face several obstacles to fully actualizing their research potential. …”
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    Grant-Writing Bootcamp: An Intervention to Enhance the Research Capacity of Academic Women in STEM
  6. 1806
    “…Off-target DNA cleavage is a paramount concern when applying CRISPR-Cas9 gene-editing technology to functional genetics and human therapeutic applications. …”
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    Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity
  7. 1807
    “…Given the gonadotoxicity of high-dose induction chemotherapy and subsequent allogeneic stem cell transplant, it is paramount that fertility preservation options are discussed and explored at the time of diagnosis as fertility preservation has been associated with greater quality of life in survivors. …”
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    Timing Embryo Preservation for a Patient with High-Risk Newly Diagnosed Acute Myeloid Leukemia
  8. 1808
    “…Marine biofouling is a paramount phenomenon in the marine environment and causes serious problems to maritime industries worldwide. …”
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    Minireview: algal natural compounds and extracts as antifoulants
  9. 1809
    “…This case highlights that careful handling of the specimen tissue intraoperatively is paramount as cells implanted in the wound site can survive and undergo malignant transformation. …”
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    A case report of wound site seeding following cholecystectomy for dysplastic gallbladder
  10. 1810
    “…Respecting the individual’s right of self-determination, to do good, prevent harm, and provide equity in access to services is paramount, even when that individual is obese.…”
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    How Ethical Is Our Current Delivery of Care to Patients with Severe and Complicated Obesity?
  11. 1811
    “…Consequently, as node betweenness proves to be paramount to attracting new links – as well as strengthening existing links –, we propose the new Weighted Betweenness Preferential Attachment (WBPA) model, which renders quantitatively robust results on realistic network metrics. …”
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    Weighted Betweenness Preferential Attachment: A New Mechanism Explaining Social Network Formation and Evolution
  12. 1812
    “…Diabetes is well studied in Saudi Arabia; however, there seems to be little research in the area of education and health care delivery. This is of paramount importance to offset the perceived impact on health care delivery services, to lessen chronic diabetes complications, and to reduce the expected morbidity and mortality from diabetes.…”
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    Epidemiology, Clinical and Complications Profile of Diabetes in Saudi Arabia: A Review
  13. 1813
    “…Early recognition and treatment of these pathologies is paramount in order to minimise the risk of long-term sequelae. …”
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    Resolution of Consumptive Hypothyroidism Secondary to Infantile Hepatic Hemangiomatosis with a Combination of Propranolol and Levothyroxine
  14. 1814
    “…We review the existing literature regarding the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of ischemic hepatitis, which is associated with high mortality; therefore early recognition and treatment of the underlying cause are paramount.…”
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    Atypical Presentation of Cardiac Tamponade as a Cause of Acute Liver Injury: Case Report and Review of Literature
  15. 1815
    “…This enhanced chemical understanding is paramount for the rational control of film deposition and the fabrication of superior optoelectronic devices.…”
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    Transformation from crystalline precursor to perovskite in PbCl(2)-derived MAPbI(3)
  16. 1816
    “…As such, identifying the specific injuries known to place patients at risk for failure with nonoperative management is of paramount importance. Although controversy remains regarding the optimal treatment of grade III MCL injuries, it is generally accepted that MCL ruptures from the distal tibia attachment require operative fixation. …”
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    Distal Knee Medial Collateral Ligament Repair With Suture Augmentation
  17. 1817
    “…Therefore regular reassessment is paramount for successful treatment. DECLARATION OF INTEREST: None.…”
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    The transition from child and adolescent to adult mental health services with a focus on diagnosis progression
  18. 1818
    “…When elevated serum hCG is discovered during the work up of a gynecologic tumor, it is paramount to identify the source of hCG prior to initiation of treatment. …”
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    hCG production by mucinous adenocarcinoma of the ovary in a reproductive aged woman
  19. 1819
    “…These impurities are found to hamper the effective utilisation of graphene in whereby surface area is of paramount importance. When non-contaminated graphene is used to fabricate supercapacitor microelectrodes, a capacitance value closest to the predicted theoretical capacitance for graphene is obtained. …”
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    Silicon as a ubiquitous contaminant in graphene derivatives with significant impact on device performance
  20. 1820
    “…[Image: see text] Microscopic lenses are paramount in solar energy harvesting, optical devices, and imaging technologies. …”
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    Extraordinary Focusing Effect of Surface Nanolenses in Total Internal Reflection Mode
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