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  1. 1861
    “…With increasing healthcare expenditures and limited public healthcare resources, cost-benefit analyses become paramount in informing healthcare resource allocation decisions. …”
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    Conducting a Cost-Benefit Analysis of Transitional Care Programmes: The Key Challenges and Recommendations
  2. 1862
    “…To tackle this crucial issue, however, we should first be able to answer a question of paramount importance, that is, why does autoimmunity affect women more than men? …”
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    Sex and autoimmune disease: Four mechanisms pointing at women
  3. 1863
    por Volk, T., Kox, W.J.
    Publicado 2000
    “…Endothelial cells can be the prime target for an infection and infected endothelial cells may serve as an initiating system for a systemic response as these cells are able to secrete many mediators known to be of paramount importance. Endothelial cell functions in turn are regulated by these circulating mediators. …”
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    Endothelium function in sepsis
  4. 1864
    “…Avoiding intubation is paramount to the management of oncologic patients with ARF. …”
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    Noninvasive Oxygen Therapies in Oncologic Patients
  5. 1865
    “…This study asserts that substrate channeling is modulated by allosteric hotspots that alter protein energy landscape, thereby allowing the protein to adopt transient conformations paramount to function.…”
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    Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation
  6. 1866
    “…Multiprotein complexes catalyze vital biological functions in the cell. A paramount objective of the SPINE2 project was to address the structural molecular biology of these multiprotein complexes, by enlisting and developing enabling technologies for their study. …”
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    Robots, pipelines, polyproteins: Enabling multiprotein expression in prokaryotic and eukaryotic cells
  7. 1867
    “…Elucidating the molecular pathogenesis of these viruses is paramount for the development of effective therapeutic strategies. …”
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    Molecular Pathogenicity of Enteroviruses Causing Neurological Disease
  8. 1868
    “…Further studies are required in the field to further investigate these antimicrobial properties in different populations. This is of paramount importance in the antimicrobial resistance era, where clinicians have limited therapeutic options to combat problematic infections.…”
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    Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
  9. 1869
    “…Selection of appropriate manufacturing processes and underused supply chains is paramount to the success of these operations. A simplified medical face shield design is presented which repurposes an assortment of existing alternative supply chains. …”
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    Exploration of alternative supply chains and distributed manufacturing in response to COVID-19; a case study of medical face shields
  10. 1870
    “…Coupling myoelectric and mechanical signals during voluntary muscle contraction is paramount in human–machine interactions. Spatiotemporal differences in the two signals intrinsically arise from the muscular excitation–contraction process; however, current methods fail to deliver local electromechanical coupling of the process. …”
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    Locally coupled electromechanical interfaces based on cytoadhesion-inspired hybrids to identify muscular excitation-contraction signatures
  11. 1871
    “…Therefore, remediation of land contamination is of paramount importance. Phytoremediation is an eco-friendly approach that could be a successful mitigation measure to revegetate heavy metal-polluted soil in a cost-effective way. …”
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    Phytoremediation: A Promising Approach for Revegetation of Heavy Metal-Polluted Land
  12. 1872
    “…We thus define a Scale Threshold for societies, beyond which growth in information processing becomes paramount, and an Information Threshold, which once crossed facilitates additional growth in scale. …”
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    Scale and information-processing thresholds in Holocene social evolution
  13. 1873
    “…Further research exploring such phenomenon is of paramount importance to explain how these tumors develop.…”
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    Chondro-Osseous Metaplasia in Ependymoma: A Rare Histopathological Finding
  14. 1874
    “…Here, we use millions of unique sequences from a DNA-based digital data archival system to study the oligonucleotide copy unevenness problem and show that the two paramount sources of bias are the synthesis and amplification (PCR) processes. …”
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    Quantifying molecular bias in DNA data storage
  15. 1875
    “…The current review provides a paramount insight into the available animal models of SARS-CoV-2, SARS-CoV, and MERS-CoV for the management of the diseases.…”
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    A Comprehensive Review of Animal Models for Coronaviruses: SARS-CoV-2, SARS-CoV, and MERS-CoV
  16. 1876
    “…A better understanding of these mechanisms at the cellular and molecular level is of paramount importance for the development of targeted prenatal MMC therapies to minimize or eliminate the effects of the injury and improve neurological function. …”
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    Spinal Cord Injury in Myelomeningocele: Prospects for Therapy
  17. 1877
    “…The dysregulation of these two paramount pathways has been implicated in numerous diseases, including cancer. …”
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    Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics
  18. 1878
    “…Radiological evaluation is of paramount importance and essential to rule out any occult vascular insult. …”
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    Innocuous wound with occult central vascular injury: A case report
  19. 1879
    “…Information on the age at onset distribution of the asymptomatic stage of a disease can be of paramount importance in early detection and timely management of that disease. …”
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    Estimating the age at onset distribution of the asymptomatic stage of a genetic disease based on pedigree data
  20. 1880
    “…The prior identification and optimization of such risk factors is considered paramount to minimize the incidence of these infections. …”
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    Infection Risk-Adjusted Antibiotic Prophylaxis Strategies in Arthroplasty: Short Review of Evidence and Experiences of a Tertiary Center in Spain
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