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  1. 1921
    “…On this account, the delicate balance of the redox potential, which is tightly regulated by dozens of enzymes including NOXs, and the mitochondrial electron transport chain as well as the fluidity of glycan biosynthesis resulting from the cooperation of glycosyltransferases, glycosidases, and nucleotide sugar transporters, is paramount to cell survival. Here, we review the broad spectrum of the interplay between redox changes and glycosylation with respect to their principle consequences on human physiology.…”
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    The glyco-redox interplay: Principles and consequences on the role of reactive oxygen species during protein glycosylation
  2. 1922
    “…We argue that recognition of refugees’ conceptualization of mental health and identification of cultural protective factors is paramount to healing. Findings emphasize the need to understand historical and cultural perspectives in cross-cultural contexts for the development and implementation of culturally responsive services. …”
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    Conceptualizing Mental Health Through Bhutanese Refugee Lens: Findings from a Mixed Methods Study
  3. 1923
    “…Establishing a correct etiological diagnosis among HCM, primary RCM, and hypertrophic or restrictive phenocopies is of paramount importance for cascade family screening and therapy.…”
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    Hypertrophic Cardiomyopathy and Primary Restrictive Cardiomyopathy: Similarities, Differences and Phenocopies
  4. 1924
    por Ackermann, Maximilian, Anders, Hans-Joachim, Bilyy, Rostyslav, Bowlin, Gary L., Daniel, Christoph, De Lorenzo, Rebecca, Egeblad, Mikala, Henneck, Timo, Hidalgo, Andrés, Hoffmann, Markus, Hohberger, Bettina, Kanthi, Yogendra, Kaplan, Mariana J., Knight, Jason S., Knopf, Jasmin, Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Mahajan, Aparna, Manfredi, Angelo A., Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioannis, Muñoz, Luis E., Narasaraju, Teluguakula, Naschberger, Elisabeth, Neeli, Indira, Ng, Lai Guan, Radic, Marko Z., Ritis, Konstantinos, Rovere-Querini, Patrizia, Schapher, Mirco, Schauer, Christine, Simon, Hans-Uwe, Singh, Jeeshan, Skendros, Panagiotis, Stark, Konstantin, Stürzl, Michael, van der Vlag, Johan, Vandenabeele, Peter, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yanginlar, Cansu, Yousefi, Shida, Zarbock, Alexander, Schett, Georg, Herrmann, Martin
    Publicado 2021
    “…Until effective vaccines are developed to curb the pandemic, it is paramount to define the mechanisms and develop protective therapies to prevent organ dysfunction in patients with COVID-19. …”
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    Patients with COVID-19: in the dark-NETs of neutrophils
  5. 1925
    “…Therefore, a correct early diagnosis has paramount importance. A high index of suspicion is needed for early diagnosis, especially when the tumor involves uncommon anatomic areas.…”
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    An unusual case of chest wall glomus tumor presenting with axillary pain: a case report and literature review
  6. 1926
    “…The (1)H-NMR analysis also allowed to rule out the presence of copal, a resin found in the pigment cover from paramount chiefs from the Mayan society. Additionally, a protocol for the extraction of the organic fraction from the bone segment without visible signs of analysis was developed, thus broadening the techniques available to investigate these valuable samples.…”
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    An Insight to the Composition of Pre-Hispanic Mayan Funerary Pigments by (1)H-NMR Analysis
  7. 1927
    “…Electric vehicles (EVs) play a paramount role in the electrification revolution towards the reduction of the carbon footprint. …”
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    The Latest Trends in Electric Vehicles Batteries
  8. 1928
    “…Understanding the relationships between biological processes is paramount to unravel pathophysiological mechanisms. …”
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    Iliski, a software for robust calculation of transfer functions
  9. 1929
    “…We screened 23 drugs, from which three (saquinavir, valrubicin and aprepitant) show a paramount predicted binding affinity (-9.1, -9.6 and -9.2 kcal/mol, respectively) against SARS-CoV-2 Nsp15. …”
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    Targeting SARS-CoV-2 nonstructural protein 15 endoribonuclease: an in silico perspective
  10. 1930
    “…For these immunotherapies to positively impact patient outcomes, optimal selection of agents and treatment scheduling, especially in conjunction with existing treatment paradigms, is paramount. Immunotherapies also warrant specific and unique considerations regarding patient management, emphasizing both the prompt identification and treatment of potential toxicities. …”
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    Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of urothelial cancer
  11. 1931
    “…Deciphering translation is of paramount importance for the understanding of many diseases, and antibiotics played a pivotal role in this endeavour. …”
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    Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA
  12. 1932
    “…With aging populations, understanding diverse groups of older adults is paramount. We completed a systematic search and scoping review of research in Canada to quantify and articulate the scale and scope of research on LGBTQ+ aging. …”
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    LGBTQ+ Aging Research in Canada: A 30-Year Scoping Review of the Literature
  13. 1933
    “…Having access to testing is paramount in preventing future infections and receiving adequate treatment. …”
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    Dengue Detection: Advances in Diagnostic Tools from Conventional Technology to Point of Care
  14. 1934
    “…The use of appropriate personal protective equipment, particularly focusing on protection from aerosolized particles, is paramount to reduce infection risk. However, there are opportunities for future research.…”
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    Pediatric Airway Management in Times of COVID-19—a Review of the Evidence and Controversies
  15. 1935
    “…It reduces potential drug interactions and many postoperative complications; however, appropriate patient selection is paramount to its success. General anesthesia remains the primary technique for patients who are considered unsuitable for the topical/regional technique. …”
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    Anesthesia Considerations for Cataract Surgery in Patients with Schizophrenia: A Narrative Review
  16. 1936
    “…BACKGROUND: Population estimates are of paramount importance for calculating occurrence and association measures although they can be affected by problems of accuracy and completeness. …”
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    Trends in epidemiology: the role of denominator fluctuation in population based estimates
  17. 1937
    “…As material properties depend on the degree of cure, its accurate estimation is of paramount interest and the main objective in this work. …”
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    Cure Kinetics and Inverse Analysis of Epoxy-Amine Based Adhesive Used for Fastening Systems
  18. 1938
    “…To advance the field in an impactful manner, it is paramount to understand the molecular underpinnings of PBSs. …”
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    Molecular insights and future frontiers in cell photosensitization for solar-driven CO(2) conversion
  19. 1939
    “…As a result, an assessment of the cytotoxicity of polycations and elucidation of the mechanisms of polycation toxicity is of paramount importance. In this study, we examined in detail the effects of a variety of water-soluble, positively charged synthetic polyelectrolytes on in vitro cytotoxicity, cell and nucleus morphology, and monolayer expansion changes. …”
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    Revisiting the Cytotoxicity of Cationic Polyelectrolytes as a Principal Component in Layer-by-Layer Assembly Fabrication
  20. 1940
    “…Background: Accurate viral load (VL) determination is paramount to determine the efficacy of anti-HIV-1 therapy. …”
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    maxRatio improves the detection of samples with abnormal amplification profiles on QIAgen’s artus HIV-1 qPCR assay
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