“…The active inhibitors are mostly non-toxic to the HeLa cancer cell line, and several ligands show synergy with topotecan, a topoisomerase 1 poison in clinical use. Thus, novel berberine derivatives can be considered as candidates for adjuvant therapy against cancer.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison, such as topotecan, thus, decreasing their efficacy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The paper provides the mechanical properties of tyre bales required for geotechnical projects, as follows: the unit weight—0.515 Mg/m(3), the Young’s modulus—826 kPa, the Poison’s ratio—0.11, the dry tyre–tyre interface: cohesion of 0.03 kPa and friction angle of 46.0°, the wet tyre–soil interface: cohesion 0.77 kPa and a friction angle of 29.6°, creep deformation of 6.1% of the average height of the bale, and no stiffness degradation of tyre bales under cyclic load. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All three TDP1 inhibitors had no effect on TOP1 activity and acted synergistically with the TOP1 poison SN-38 to increase the amount of TOP1 cleavage-induced DNA damage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Enteric glia activity was altered by the poison fluorocitrate (FC; 10 µmol kg(−1) i.p.) before inducing colitis in animals (2,4-dinitrobenzenesulfonic acid, DNBS; 30 mg in 0.25 mL EtOH 50%), and visceral sensitivity, colon damage, and glia activation along the pain pathway were studied. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among these species, one may highlight Lonomia obliqua caterpillar, which, when touched by humans, can poison them through their bristles. Therefore, better acknowledging the mechanisms involved in envenomation caused by Lonomia obliqua caterpillar bristle extract (LOCBE) may contribute to further treatments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Fluoride is commonly found in the soil and water environment and may act as chronic poison. A large amount of fluoride deposition causes serious harm to the ecological environment and human health. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A retrospective observational study was conducted in all the reported cases from 2000 to 2020 in French poison control centers (PCCs). Two hundred and eighteen cases of bites were recorded. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Viperin, but not HemN, was gradually poisoned by molecular oxygen in vitro, forming an apparent [3Fe–4S](+) form that was readily reactivated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Zinc is essential for plant growth, but excessive zinc (Zn) is bound to poison plants, and cadmium (Cd) is a significant environmental pollutant. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These phenotypes establish a dual mechanism of poison peptide effect and haploinsufficiency that collectively contribute to DCM pathogenesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The experiments recorded in this paper confirm the observations of Friedberger that acutely toxic bodies can be produced from typhoid bacilli by the action of sensitizer and complement and that, when small quantities of bacteria are used, an excess of sensitization either interferes with the formation of the poisons or leads to a cleavage of the bacterial proteid beyond the poisonous intermediate products spoken of as anaphylatoxins. …”
Enlace del recurso
Enlace del recurso

“…Since polar groups can poison the metal centers in catalysts, the incorporation of polar comonomers usually comes at the expense of catalytic activity and polymer molecular weight. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, the reduction rate of the poison material 4′-O-methylpyridoxine (MPN) in ginkgo kernel juice increased by more than 16.40% with ultrasound treatment at 173.88 W/L after the fermentation for 48 h. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We performed a 10-year retrospective study (2011–2020) by analyzing data from the Ramathibodi Poison Center (RPC) database (RPC Toxic Exposure Surveillance System). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is also known that the intake of the chemical poison nitrosamine and its nanopreparations can promote the development of liver injuries, such as FLD, and hepatic fibrosis, and significantly shorten the formation time of the liver cancer cycle. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Forty percent of responding women knew that toxoplasmosis is caused by an infection, but 21% thought that a poison causes it. The highest level of knowledge was about cats and T. gondii ; 61% responded that the organism is shed in the feces of infected cats and 60% responded that people could acquire toxoplasmosis by changing cat litter. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…But colchicine, also a karyolytic poison causing pronounced nuclear changes, does not alter in the least the yield of adenomas to urethane when administered concurrently. …”
Enlace del recurso
Enlace del recurso

“…A low pH decreased the effectiveness of EDTA as a poison. The data are consistent with the possibility that non-penetrating metal-binding agents are toxic because of the irreversible removal of essential cations from the cell. …”
Enlace del recurso
Enlace del recurso

“…METHODS: A retrospective chart review of cases of acute salicylate toxicity and THL reported to the Illinois Poison Control Center (IPC) from 2001–2002 was performed. …”
Enlace del recurso
Enlace del recurso