“…Recent studies suggest that of the molecules postulated to function as inhibitors of the NADPH oxidase family of enzymes iodonium analogs known to broadly interfere with flavin dehydrogenase function demonstrate mechanistic validity as NADPH oxidase poisons. In recent work, we have produced a series of novel iodonium compounds as putative inhibitors of these oxidases. …”
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“…Analysis of hair root samples may also be used to document acute poisoning in postmortem toxicology, and the analysis of the hair shaft can document long-term use of drugs depending on the length of the hair being evaluated.…”
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“…They also have many uses in forensic science to determine the minimum post-mortem interval and provide valuable information about the movement of the body, cause of the death, drug use, or poisoning. It has also been proposed that they may be used as model organisms to replace mammal systems in research. …”
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“…BACKGROUND: Traditionally, the herb Byttneria pilosa Roxb. is used for bone fractures, boils, scabies, rheumatalgia, snake bites, syphilis, elephantiasis, poisoning, and eye infection. Scientific reports suggest that it has significant anti-inflammatory, analgesic, anti-diarrheal, anxiolytic, locomotion, sedative and anti-obesity effects. …”
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“…Me-ION shows a tendency to occur as mass poisonings around the world with a clear predilection for poor societies in developing countries. …”
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“…The consumption of bivalves contaminated with the potent neurotoxin domoic acid (DA) can cause amnesic shellfish poisoning in humans. The aim of this study was to determine seasonal differences in occurrence and accumulation of this phycotoxin in European oysters (Ostrea edulis Linnaeus, 1758) (n = 46), Queen scallops (Aequipecten opercularis Linnaeus, 1758) (n = 53), and edible ascidians of the Microcosmus spp. …”
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“…These biochemical changes seem to relate to the toxicological effects of oxycodone and potentially acylcarnitines constituting a biologically relevant biomarker for opioid poisonings. More studies are needed in order to elucidate the potential of acylcarnitines as biomarker for oxycodone toxicity and their relation to CNS-depressant effects.…”
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“…Polynucleotide Kinase-Phosphatase (PNKP) is a bifunctional enzyme that possesses both DNA 3′-phosphatase and DNA 5′-kinase activities, which are required for processing termini of single- and double-strand breaks generated by reactive oxygen species (ROS), ionizing radiation and topoisomerase I poisons. Even though PNKP is central to DNA repair, there have been no reports linking PNKP mutations in a Microcephaly, Seizures, and Developmental Delay (MSCZ) patient to cancer. …”
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“…The majority (68.5%) of visits were related to overdoses (poisoning), with a mean age of 11.3 years and a majority female (53%). …”
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“…Staphylococcal food poisoning outbreaks are caused by the ingestion of food contaminated with staphylococcal enterotoxins (SEs). …”
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“…The better tolerance for CO poisoning also endowed the PtPdCu hexapods with superior durability relative to commercial Pt/C.…”
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“…The strong interaction between gold and the composite support, accompanied by the increase of labile lattice oxygen species and the decrease of surface basicity, led to a high CO oxidation rate and resistance towards CO(2) poisoning.…”
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“…However, they are expensive and Pt has the tendency to be poisoned from the intermediate compounds, formed during the methanol oxidation reaction (MOR). …”
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“…Our modeling showed that these larger fluctuations occurred because exposure of GDP-tubulin on the microtubule end transiently ‘poisoned’ growth, yielding a wider range of growth rates compared to GTP only conditions. …”
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“…For a better understanding of the SO(2) poisoning mechanism over ceria-based catalysts, the sulfation effect of the Ce/TiO(2) catalyst on the SCR activity over a wide reaction temperature range was systematically studied via comprehensive characterizations, in situ DRIFT studies and kinetic studies. …”
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“…However, most DDSs themselves cannot serve as diagnostic reagents and must be metabolized, by which they may become poisonous and even cause immune reactions. In this study, a novel self-delivery drug–drug system (SDDS) nanohybrid based on the coordination assembly of a photodynamic reagent, tetra-(4-carboxyphenyl)porphyrin (TCPP), and a chemotherapy reagent, cis-platinum, was designed and synthesized. …”
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“…Pesticides are designed to be poisonous and are intentionally released into the environment to combat the menace caused by these noxious pests. …”
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“…In 2019, several dogs were poisoned in the river Lech (Germany) by the benthic anatoxin-a-producing genus Tychonema. …”
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“…Cyanobacteria, which develop abundantly in aquatic ecosystems, can be harmful to humans and animals not only by releasing toxins that cause poisoning but also by provoking cytogenetic effects. …”
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“…This unique pattern, termed PANTHOS (poisonous anthos (flower)), is also present in AD brains. …”
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