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  1. 9221
    Publicado 1996
    “…We suggest a model based on transcriptionally mediated DNA damage, a novel mechanism of action of topo-I poisons.…”
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    Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity
  2. 9222
    por Nichols, Henry J., Walker, John E.
    Publicado 1923
    “…(c) Death from mercurial poisoning was produced in rabbits by a single application of a large amount of calomel ointment. 4. …”
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    EXPERIMENTAL OBSERVATIONS ON THE PROPHYLAXIS AND TREATMENT OF SYPHILIS
  3. 9223
    por Höber, Rudolf
    Publicado 1947
    “…The commonly used detergents have a poisonous effect, which is due to the non-polar-polar configuration of their organic anion. …”
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    STUDIES ON THE PHYSIOLOGICAL EFFECTS OF NON-POLAR-POLAR ORGANIC ELECTROLYTES : I. THE INFLUENCE UPON THE RESTING POTENTIAL OF FROG MUSCLE
  4. 9224
    Publicado 1978
    “…There is, however, a residual ATP-dependent Ca uptake that is insensitive to the aforementioned poisons; this (nonmitochondrial) Ca uptake is blocked by tetracaine, mersalyl and A-23187. …”
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    Calcium buffering in presynaptic nerve terminals. I. Evidence for involvement of a nonmitochondrial ATP-dependent sequestration mechanism
  5. 9225
    por Hadidian, Zareh, Hoagland, Hudson
    Publicado 1941
    “…An activation energy of 17,500 calories is obtained for the oxidation of succinate to fumarate in the presence of the beef heart extract partially poisoned by pyrophosphate. Evidence is presented that this value corresponds to a link in the respiratory chain other than that of succino-dehydrogenase or cytochrome c-cytochrome oxidase. 4. …”
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    CHEMICAL PACEMAKERS : III. ACTIVATION ENERGIES OF SOME RATE-LIMITING COMPONENTS OF RESPIRATORY SYSTEMS
  6. 9226
    Publicado 1992
    “…Formation of tubular lysosomes was microtubule-mediated and energy-dependent; interestingly, however, maintenance of the tubulated lysosomes only required microtubules and was insensitive to energy poisons. Upon removal of BFA, the tubular lysosomes rapidly recovered in an energy-dependent process. …”
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    The morphology but not the function of endosomes and lysosomes is altered by brefeldin A
  7. 9227
    “…These enzymes are also the cellular targets of certain classes of chemotherapeutic agents termed topoisomerase poisons. A new human topoisomerase isoform, IIIa, was discovered in 1996, which is thought to have roles in genome stability and possibly chromosome separation during mitosis. …”
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    Expression of topoisomerase III α in normal and neoplastic tissues determined by immunohistochemistry using novel monoclonal antibody
  8. 9228
    “…In the present study, we have evaluated the effects of aspirin and NS-398 non-steroidal anti-inflammatory drugs on sensitivity of Caco-2 cells to irinotecan (CPT 11) and etoposide (Vp-16) topoisomerase poisons. We find that aspirin co-treatment is able to prevent anticancer drug-induced toxicity, whereas NS-398 co-treatment poorly affects anticancer drug-induced apoptosis. …”
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    Effect of non-steroidal anti-inflammatory drugs on colon carcinoma Caco-2 cell responsiveness to topoisomerase inhibitor drugs
  9. 9229
    “…In age-adjusted analyses in which IQ scores were classified into 4 groups, relative to the highest scoring category, the hazard ratio in the lowest was elevated for all injury types: poisonings (hazard ratio (HR) = 5.82, 95% confidence interval (CI): 4.25, 7.97), fire (HR = 4.39, 95% CI: 2.51, 7.77), falls (HR = 3.17, 95% CI: 2.19, 4.59), drowning (HR = 3.16, 95% CI: 1.85, 5.39), and road injury (HR = 2.17, 95% CI: 1.91, 2.47). …”
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    IQ in Early Adulthood, Socioeconomic Position, and Unintentional Injury Mortality by Middle Age: A Cohort Study of More Than 1 Million Swedish Men
  10. 9230
    “…Molecular oxygen is toxic for anaerobic organisms but it is also obvious that oxygen is poisonous to aerobic organisms as well, since oxygen plays an essential role for inducing molecular damage. …”
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    Cellular and Biochemical Actions of Melatonin which Protect Against Free Radicals: Role in Neurodegenerative Disorders
  11. 9231
    “…We recorded and studied the ED visits of children, excluding planned ED visits, visits for trauma/poisoning and those that were assigned non deferrable/critical triage codes. …”
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    Primary paediatric care models and non-urgent Emergency Department utilization: an area-based cohort study
  12. 9232
    “…BACKGROUND: The dinoflagellate Alexandrium minutum typically produces paralytic shellfish poisoning (PSP) toxins, which are known only from cyanobacteria and dinoflagellates. …”
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    Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum
  13. 9233
    por Sukumar, Piruthivi, Beech, David J.
    Publicado 2010
    “…The study shows that Pb(2+) is a relatively potent stimulator of the TRPC5 channel, generating the hypothesis that a function of the channel is to sense metal ion poisoning.…”
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    Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb(2+))
  14. 9234
    “…Low-energy trauma in elderly individuals and poisonings were excluded. RESULTS: A total of 453 cases of trauma-related death occurred during the study period, and 327 of those met the inclusion criteria. …”
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    Rural High North: A High Rate of Fatal Injury and Prehospital Death
  15. 9235
    “…National statistics on production and trade of pesticides and poisoning incidents were lacking in many countries. …”
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    Status of Legislation and Regulatory Control of Public Health Pesticides in Countries Endemic with or at Risk of Major Vector-Borne Diseases
  16. 9236
    por Correa, Elon, Goodacre, Royston
    Publicado 2011
    “…BACKGROUND: The rapid identification of Bacillus spores and bacterial identification are paramount because of their implications in food poisoning, pathogenesis and their use as potential biowarfare agents. …”
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    A genetic algorithm-Bayesian network approach for the analysis of metabolomics and spectroscopic data: application to the rapid identification of Bacillus spores and classification of Bacillus species
  17. 9237
    “…CONCLUSION: Based on the data from this case and from previously published poisoning cases, as well as on the experience of our research group, we conclude that, using similar matrices for the study of chronic drug exposure, children present with a higher cocaine concentration in hair and they experience more serious deleterious acute effects, probably due to a different and slower cocaine metabolism. …”
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    Hair analysis following chronic smoked-drugs-of-abuse exposure in adults and their toddler: a case report
  18. 9238
    “…This property has placed UDCA-LPE as a candidate agent for therapy of acute hepatotoxicity such as acetaminophen poisoning.…”
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    Hepatoprotectant Ursodeoxycholyl Lysophosphatidylethanolamide Increasing Phosphatidylcholine Levels as a Potential Therapy of Acute Liver Injury
  19. 9239
    “…This toxin is responsible for amnesic shellfish poisoning, which can result in illness or death in humans and regularly causes mass mortalities of marine mammals and birds. …”
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    High CO(2) and Silicate Limitation Synergistically Increase the Toxicity of Pseudo-nitzschia fraudulenta
  20. 9240
    “…Increasing Bmi1 expression in cortical neurons conferred robust protection against DNA damage-induced cell death or mitochondrial poisoning, and resulted in suppression of ROS through activation of AOR genes. …”
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    Bmi1 Is Down-Regulated in the Aging Brain and Displays Antioxidant and Protective Activities in Neurons
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