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Toxicología
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9221Publicado 1996“…We suggest a model based on transcriptionally mediated DNA damage, a novel mechanism of action of topo-I poisons.…”
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9222“…(c) Death from mercurial poisoning was produced in rabbits by a single application of a large amount of calomel ointment. 4. …”
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9223por Höber, Rudolf“…The commonly used detergents have a poisonous effect, which is due to the non-polar-polar configuration of their organic anion. …”
Publicado 1947
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9224Publicado 1978“…There is, however, a residual ATP-dependent Ca uptake that is insensitive to the aforementioned poisons; this (nonmitochondrial) Ca uptake is blocked by tetracaine, mersalyl and A-23187. …”
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9225“…An activation energy of 17,500 calories is obtained for the oxidation of succinate to fumarate in the presence of the beef heart extract partially poisoned by pyrophosphate. Evidence is presented that this value corresponds to a link in the respiratory chain other than that of succino-dehydrogenase or cytochrome c-cytochrome oxidase. 4. …”
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9226Publicado 1992“…Formation of tubular lysosomes was microtubule-mediated and energy-dependent; interestingly, however, maintenance of the tubulated lysosomes only required microtubules and was insensitive to energy poisons. Upon removal of BFA, the tubular lysosomes rapidly recovered in an energy-dependent process. …”
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9227por Lodge, A J, Anderson, J J, Ng, S W, Fenwick, F, Steward, M, Haugk, B, Horne, C H W, Angus, B“…These enzymes are also the cellular targets of certain classes of chemotherapeutic agents termed topoisomerase poisons. A new human topoisomerase isoform, IIIa, was discovered in 1996, which is thought to have roles in genome stability and possibly chromosome separation during mitosis. …”
Publicado 2000
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9228por Ricchi, P, Matola, T Di, Ruggiero, G, Zanzi, D, Apicella, A, di Palma, A, Pensabene, M, Pignata, S, Zarrilli, R, Acquaviva, A M“…In the present study, we have evaluated the effects of aspirin and NS-398 non-steroidal anti-inflammatory drugs on sensitivity of Caco-2 cells to irinotecan (CPT 11) and etoposide (Vp-16) topoisomerase poisons. We find that aspirin co-treatment is able to prevent anticancer drug-induced toxicity, whereas NS-398 co-treatment poorly affects anticancer drug-induced apoptosis. …”
Publicado 2002
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9229por Batty, G. David, Gale, Catharine R., Tynelius, Per, Deary, Ian J., Rasmussen, Finn“…In age-adjusted analyses in which IQ scores were classified into 4 groups, relative to the highest scoring category, the hazard ratio in the lowest was elevated for all injury types: poisonings (hazard ratio (HR) = 5.82, 95% confidence interval (CI): 4.25, 7.97), fire (HR = 4.39, 95% CI: 2.51, 7.77), falls (HR = 3.17, 95% CI: 2.19, 4.59), drowning (HR = 3.16, 95% CI: 1.85, 5.39), and road injury (HR = 2.17, 95% CI: 1.91, 2.47). …”
Publicado 2009
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9230por Ortiz, Genaro G, Benítez-King, Gloria A, Rosales-Corral, Sergio A, Pacheco-Moisés, Fermín P, Velázquez-Brizuela, Irma E“…Molecular oxygen is toxic for anaerobic organisms but it is also obvious that oxygen is poisonous to aerobic organisms as well, since oxygen plays an essential role for inducing molecular damage. …”
Publicado 2008
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9231por Farchi, Sara, Polo, Arianna, Franco, Francesco, Di Lallo, Domenico, Guasticchi, Gabriella“…We recorded and studied the ED visits of children, excluding planned ED visits, visits for trauma/poisoning and those that were assigned non deferrable/critical triage codes. …”
Publicado 2010
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9232por Yang, Ines, John, Uwe, Beszteri, Sára, Glöckner, Gernot, Krock, Bernd, Goesmann, Alexander, Cembella, Allan D“…BACKGROUND: The dinoflagellate Alexandrium minutum typically produces paralytic shellfish poisoning (PSP) toxins, which are known only from cyanobacteria and dinoflagellates. …”
Publicado 2010
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9233“…The study shows that Pb(2+) is a relatively potent stimulator of the TRPC5 channel, generating the hypothesis that a function of the channel is to sense metal ion poisoning.…”
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9234“…Low-energy trauma in elderly individuals and poisonings were excluded. RESULTS: A total of 453 cases of trauma-related death occurred during the study period, and 327 of those met the inclusion criteria. …”
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9235por Matthews, Graham, Zaim, Morteza, Yadav, Rajpal Singh, Soares, Agnes, Hii, Jeffrey, Ameneshewa, Birkinesh, Mnzava, Abraham, Dash, Aditya Prasad, Ejov, Mikhail, Tan, Soo Hian, van den Berg, Henk“…National statistics on production and trade of pesticides and poisoning incidents were lacking in many countries. …”
Publicado 2011
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9236“…BACKGROUND: The rapid identification of Bacillus spores and bacterial identification are paramount because of their implications in food poisoning, pathogenesis and their use as potential biowarfare agents. …”
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9237por Papaseit, Esther, Joya, Xavier, Velasco, Marta, Civit, Ester, Mota, Pau, Bertran, Marta, Vall, Oriol, Garcia-Algar, Oscar“…CONCLUSION: Based on the data from this case and from previously published poisoning cases, as well as on the experience of our research group, we conclude that, using similar matrices for the study of chronic drug exposure, children present with a higher cocaine concentration in hair and they experience more serious deleterious acute effects, probably due to a different and slower cocaine metabolism. …”
Publicado 2011
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9238por Chamulitrat, Walee, Zhang, Wujuan, Xu, Weihong, Pathil, Anita, Setchell, Kenneth, Stremmel, Wolfgang“…This property has placed UDCA-LPE as a candidate agent for therapy of acute hepatotoxicity such as acetaminophen poisoning.…”
Publicado 2012
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9239“…This toxin is responsible for amnesic shellfish poisoning, which can result in illness or death in humans and regularly causes mass mortalities of marine mammals and birds. …”
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9240por Abdouh, Mohamed, Chatoo, Wassim, El Hajjar, Jida, David, Jocelyn, Ferreira, José, Bernier, Gilbert“…Increasing Bmi1 expression in cortical neurons conferred robust protection against DNA damage-induced cell death or mitochondrial poisoning, and resulted in suppression of ROS through activation of AOR genes. …”
Publicado 2012
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