“…The results obtained from the 3D reactor model confirmed that the designed core with the proposed Case 3 BPs can achieve the target lifetime of 15 years while contributing to ~10% higher BOL reactivity suppression, ~70% lower reactivity swings, ~30% lower radial form factor and ~28% lower total peaking factor compared to the IFBA-only core.…”
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“…This is called impaired awareness of hypoglycaemia (IAH), the cause of which is unknown. We recently proposed that IAH develops through habituation, a form of adaptive memory to preceding hypoglycaemia. …”
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“…The PC physician explained the standard clinical guidelines for conducting PC consults, and CAG members proposed culturally appropriate programmatic recommendations for their ethnic group for each theme. …”
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“…This article aims at proposing guidance to ensure mental health care during the SARS-CoV epidemy in France. …”
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“…The study results indicate that swimming speed can be increased by the proposed methods and spasticity can be reduced by prolonged swim sessions with tSCS and FES. …”
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“…This article aims to propose guidance to ensure mental health care during the SARS-CoV epidemic in France. …”
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“…INTERPRETATION: Fully oral RC8 regimen was non-inferior to RS8 for treatment of early, limited Buruli ulcer and was associated with fewer adverse events. Therefore, we propose that fully oral RC8 should be the preferred therapy for early, limited lesions of Buruli ulcer. …”
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“…BACKGROUND AND OBJECTIVE: BC 007 is a substance with a novel and innovative mode of action for the first-time causal treatment of chronic heart failure, associated with the occurrence of autoantibodies against the β1-adrenoceptor, and other diseases of mostly the heart and vascular system, being accompanied by the occurrence of functionally active agonistic autoantibodies against G-protein-coupled receptors ((f)GPCR-AAb). The proposed mechanism of action of BC 007 is the neutralisation of these pathogenic autoantibodies which stimulate the respective receptor. …”
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“…Considering these factors, three different acromegaly subtypes were proposed. Type 1 tumors are dense granulated microadenomas with higher expression of p21 and SSTR2, with better prognosis. …”
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“…0.50 i po tid 1998/04/28 9.7 8.6 0.50 i po tid 1998/06/26 9.5 11.4 0.50 i po tid 1999/04/28 9.4 15.2 0.50 i po tid 2000/02/04 8.7 16.0 0.50 i po tid 2000/05/01 9.3 15.1 0.50 i po tid Baseline Values Statistic: Ca++ /PTH, Total: 910.70 /4170.00, Average: 9.49/73.16, Count: 57/57, Maximum: 11.70/211.00, Minimum: 4.90 /12.00, Variance: 1.38 /923.70, SD: 2.47/59.34 Post-Treatment with Calcitriol Statistic: Ca++ PTH, Total: 910.70/4170.00, Average: 9.49/73.16,Count: 57/57, 11.70/211.00, Minimum: 4.90/12.00, Variance: 1.38 /923.70, SD: 1.18/43.86 99% confidence interval around the 49.9 pg/ml difference was (-75.5 to -24.3 pg/ml) Proposed Clinical Trial:- Calcitriol to Prevent Hyperparathyroidism (CaPH) Trial Double-blind, randomized, parallel-controlled clinical trial stratified by history of nephrolithiasis with follow-up for 5-year duration Calcitriol Rx to keep PTH< 70 vs Ergocalcitriol to keep 25-OH D3 >30 N=100 patients/arm Visits q90 days Bone densitometry [including lateral spine] qyear Telopeptides, Crosslinks, Alkaline Phosphatase, UV/Pcalcium/creatinine,Flat Plates Exclusion: Pcreatinine>2.0,mg/dl, Ca++>10.0 mg/dl,Familial HPTH Inclusion: PTH >70 pg/ml Primary Efficacy Variable: Number of documented cases of Hypercalcemic Hyperparathyroidism Secondary Variables: Mortality, Kidney stones, Bone density, Fractures…”
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“…Consideration for same pocket insertion is proposed to be discussed with the patient, limiting the same pocket insertion to a maximum of one year, based on our clinical experience.…”
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“…Late-night salivary cortisol (LNSC) measured by enzyme immunoassay (EIA) is established as a reliable screening test and recommended as a first-line test for Cushing’s syndrome.(1,2) However, liquid chromatography-tandem mass spectrometry (LCMS), validated to measure salivary cortisol (F) and cortisone (E), has been proposed to be superior diagnostically as well as helpful in detecting saliva contaminated with topical hydrocortisone (i.e. cortisol).(3,4) We measured EIA-F, LCMS-F, and LCMS-E in 913 consecutive late-night saliva samples from patients suspected of Cushing’s syndrome. …”
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“…Conclusion: International consensus guidelines for the diagnosis and management of PHP and related disorders were recently published by Mantovani et al. in 2018. Proposed clinical and biochemical major criteria include PTH resistance, ectopic ossifications, early-onset obesity, TSH resistance, and Albright hereditary osteodystrophy (AHO; round facies, short stature, brachydactyly, developmental delay). …”
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“…However, because of anemia and altered red cells turnover, glycated albumin (GA) has been proposed as a more reliable glycemic marker in these subjects. …”
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“…Thus, A1c should be interpreted with caution in anemic patients. We propose using the gender specific correction factors for more accurate interpretation of A1c.…”
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“…CONCLUSIONS We evaluated HCM in CD, proposing this method as an additional diagnostic test for hypercortisolism. …”
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“…A target estradiol range of 110-180 pmol/L has been proposed(1). GnRH secretion is modulated by neurokinin B (NKB) acting at the NK3 receptor via hypothalamic neurons expressing kisspeptin, NKB & dynorphin (KNDy neurons). …”
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“…From 2015- 2019, we proposed NGS assay with the multigene panel to 12 patients (9 PHEOS and 3 PGLs) for whom the initial genetic test was negative. …”
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“…CONCLUSIONS: We identified a stemness-related gene panel associated with JQ1 and describe how this inhibitor modifies the stemness landscape in TNBC. Therefore, we propose a novel role for JQ1 as a stemness-targeting drug. …”
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“…While one recent study suggested that individuals with psychosis experience a progressive decline in certain cognitive domains during the first 10 years of their illness, other clinical and functional MRI-based studies have proposed that most cognitive deficits are present during the first episode and remain stable over time, possibly as a result of medication response. …”
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