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  1. 357841
    “…Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca(2+) dynamics by controlling IP(3) receptor (IP(3)R) function. Current models propose distinct roles for Bcl-2 vs. Bcl-xL, with Bcl-2 inhibiting IP(3)Rs and preventing pro-apoptotic Ca(2+) release and Bcl-xL sensitizing IP(3)Rs to low [IP(3)] and promoting pro-survival Ca(2+) oscillations. …”
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    Bcl-xL acts as an inhibitor of IP(3)R channels, thereby antagonizing Ca(2+)-driven apoptosis
  2. 357842
    “…We review the different potential molecular targets and distinctive senotherapeutic strategies in adipose tissues and pancreatic β cells. We propose the novel concept of a dual-target tailored approach in senotherapy against diabetes.…”
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    Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells
  3. 357843
    “…The purpose of this study was to thoroughly investigate to what extent biases have influenced the performance of a range of previously proposed and promising convolutional neural networks (CNNs), and to determine what performance can be expected with current CNNs on a realistic and unbiased dataset. …”
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    Automatic coronavirus disease 2019 diagnosis based on chest radiography and deep learning – Success story or dataset bias?
  4. 357844
    “…Objective: Ovarian response indexes have been proposed in assisted reproductive technology (ART) in order to optimize live birth rates (LBR), adjusting ovarian stimulation (OS), and minimizing risks. …”
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    Are There Ovarian Responsive Indexes That Predict Cumulative Live Birth Rates in Women over 39 Years?
  5. 357845
    “…Furthermore, unlike the necroptotic pathway, the starvation-evoked CAMK2-mediated MLKL phosphorylation protected cells from starvation-induced death. We propose that upon nutrient deprivation, MLKL is activated by CAMK2, which in turn facilitates membrane scission needed for autophagosome maturation, allowing the proper fusion of the autophagosome with lysosome and the subsequent substance degradation. …”
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    CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux
  6. 357846
    por Panuganti, S, Dhanji, S, Green, T, Wang, R
    Publicado 2022
    “…This can primarily be explained by its ability to drain the bladder without creating inflammation and friction in the urethra. Therefore, we propose that any team caring for a patient with an IPP and a planned, prolonged indwelling transurethral catheterization consult urology services to have a suprapubic tube temporarily placed. …”
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    Erosion of Inflatable Penile Prosthesis with Prolonged Foley Catheterization in the COVID-19 Era
  7. 357847
    “…Moreover, one of most outstanding features of coronavirus infection is the diversity of receptor usage, which includes the newly proposed human CD147 (hCD147) as a possible co-receptor for SARS-CoV-2 entry. …”
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    Development of a Novel Human CD147 Knock-in NSG Mouse Model to Test SARS-CoV-2 Viral Infection
  8. 357848
    “…BACKGROUND: Gender differences in muscle activity during landing have been proposed as a possible contributing factor to the greater incidence of anterior cruciate ligament injuries in women. …”
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    What are gender differences in lower limb muscle activity during jump–landing tasks? A systematic review and meta-analysis
  9. 357849
    “…The use of contrast agents including (18)O, (68)Zn or (63)Cu, isotopes with a high cross section for low-energy protons in nuclear reactions producing PET emitters, has been proposed to enhance the PET signal in the last millimeters of the proton path. …”
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    In vivo production of fluorine-18 in a chicken egg tumor model of breast cancer for proton therapy range verification
  10. 357850
    “…The dielectric composite development and quantifications presented in this article proposes a novel active toughening technology for high-performance composite applications in numerous sectors.…”
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    Electromagnetic field controlled domain wall displacement for induced strain tailoring in BaTiO(3)-epoxy nanocomposite
  11. 357851
    “…BACKGROUND: Increasing youth mental health problems over time correlate with increasing rates of social media use (SMU); however, a proposed contributory relationship remains unproven. …”
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    Exploring Use Patterns and Racial and Ethnic Differences in Real Time Affective States During Social Media Use Among a Clinical Sample of Adolescents With Depression: Prospective Cohort Study
  12. 357852
    “…The relevance of each PRO and the appropriateness (A) and feasibility (F) of the proposed PROM were assessed (Likert scale 1=strongly agree; 9=strongly disagree). …”
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    Defining a Standard Set of Patient-Reported Outcomes for Patients With Advanced Ovarian Cancer
  13. 357853
    “…PrEP is highly effective when taken as prescribed, but uptake and adherence have been low, with high discontinuation rates among youth. OBJECTIVE: We propose to develop and pilot a multi-component, technology-based intervention to promote PrEP usage. …”
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    Optimizing an mHealth Intervention to Improve Uptake and Adherence to HIV Pre-exposure Prophylaxis in Young Transgender Women: Protocol for a Multi-Phase Trial
  14. 357854
    “…At present, there is an urgent need to develop a low-cost, easy-to-promote, climate- and site-independent facility that combines the functions of crop cultivation and phenotype acquisition. We propose a movable cabin-type intelligent artificial climate chamber, and build an environmental control system, a crop phenotype monitoring system, and a crop phenotype acquisition system. …”
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    Evaluation of an intelligent artificial climate chamber for high-throughput crop phenotyping in wheat
  15. 357855
    “…First, respondents articulated that when selecting donors and recipients, healthcare workers should prevent donors from making a wrong decision and safeguard the future child’s well-being by minimizing health risks and selecting recipients based on their parental capabilities. Second, they proposed to provide a reasonable compensation and to increase societal awareness on the scarcity of donor oocytes to diminish barriers for donors. …”
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    Stakeholders views on the ethical aspects of oocyte banking for third-party assisted reproduction: a qualitative interview study with donors, recipients and professionals
  16. 357856
    “…Roles of noncoding RNAs in COPD have been proposed, however, not many studies have systematically investigated the crosstalk among various transcripts in this context. …”
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    Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease
  17. 357857
    “…CONCLUSION: Pre-treatment rENE is an independent prognostic marker for survival in patients with LAHNSCC treated radically with CCRT that can be used as a potential predictive marker for response to treatment and hence stratify patients into responders vs. non-responders. We propose the mahajan rENE grading system applicable on CT, magnetic resonance imaging, positron emission tomography–contrast-enhanced CT, and ultrasound.…”
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    Prognostic Value of Radiological Extranodal Extension Detected by Computed Tomography for Predicting Outcomes in Patients With Locally Advanced Head and Neck Squamous Cell Cancer Treated With Radical Concurrent Chemoradiotherapy
  18. 357858
    “…When another model organism’s (nematode) response to these radiation differences was similarly analyzed, DNAstar-D also resulted in the most conservative expression patterns. Therefore, we would propose DESeq2 (“DNAstar-D”) as an appropriate software tool for differential gene expression studies for treatments expected to give subtle transcriptome responses. …”
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    A transcriptome software comparison for the analyses of treatments expected to give subtle gene expression responses
  19. 357859
    “…Heart failure (HF) has been proposed as a major contributor to these disparities. …”
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    Epidemiology of geographic disparities in heart failure among US older adults: a Medicare-based analysis
  20. 357860
    “…Logistic regression was used to analyze the relationship between FHS–CVD risk score, POD CSF biomarkers, and POD incidence. The proposed mediating effect of CSF biomarkers was evaluated using Mediation Analysis with 10,000 bootstrapped iterations. …”
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    The Relationship Between Cardiovascular Disease Risk Score and Postoperative Delirium: The PNDABLE Study
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