“…BACKGROUND: The US Food and Drug Administration (FDA) interchangeability guidelines state that the primary endpoint in a switching study should assess the impact of switching between the proposed interchangeable product and the reference product on clinical pharmacokinetics (PK) and pharmacodynamics (if available), as these assessments are generally sensitive to changes in immunogenicity and/or exposure that may arise due to switching. …”
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“…Therefore, we abolish the existing classification and propose to restore the generic status of Gongromeriza and Psilobotrys. …”
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“…Several mechanisms have been proposed to explain these phenomena. Our study is the first systematic research on CL/P and CL/P-related perinatal deaths based on birth defects surveillance. …”
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“…Patients are content to undergo day of surgery consent and multiple short questionnaires pre-operatively. Proposed data, especially pharmacological, should be carefully considered for their relevance to modifiable mechanisms that can lead to POD. …”
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“…However, when the labrum is deficient and the bone loss is minimal, labral reconstruction has been recently proposed as an alternative. A new technique called Anterior Labral Circumferential Onlay Technique (ALCOT) was developed, which reconstructs the labrum using the long head of the biceps tendon. …”
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“…The negative impact of the Part D coverage gap (high out-of-pocket cost sharing) on medication adherence and persistence for Medicare-eligible dialysis patients has implications for currently proposed Medicare end-stage renal disease bundled reimbursement payment and requires more research.…”
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“…The TNM stage, Eastern Cooperative Oncology Group performance status, and Lung Immune Prognostic Index showed significant correlations with PFS. We proposed a predictive model based on eight radiomics features to determine the risk of chemoimmunotherapy resistance among patients with SCLC (validation set 1: mPFS, 12.0 m vs 5.0 m, C-index=0.634; validation set 2: mPFS, 10.8 m vs 6.1 m, C-index=0.617). …”
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“…AUTHORS’ CONCLUSIONS: Commissioners and intervention developers should ensure interventions provide sufficient theoretical evidence for the logic behind the proposed intervention and should improve their consideration of equity within the interventions Research on intergenerational interventions need more consistent and agreed measures for reporting outcomes including community outcomes (core outcome sets). …”
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“…Qualitative (visual) analysis classified the PET/CT scans into three groups based on the presence and number of focal [(18)F]FDG-avid lesions as well as the degree of diffuse [(18)F]FDG uptake in the BM. The proposed automated method for BM metabolism assessment is based on an initial CT-based segmentation of the skeleton, its transfer to the SUV PET images, the subsequent application of different SUV thresholds, and refinement of the resulting regions using postprocessing. …”
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“…The current study was proposed to explore the role of dietary propolis (PR) supplementation in alleviating the negative effects of columnaris disease (CD) challenge on the growth performance, plasma biochemicals, antioxidant activity, stress indicators, and immunological reactions of common carp (Cyprinus carpio) fish. …”
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“…DP was also better tolerated in these studies as compared to most alternatives that have been proposed to replace SP which have proved to be too poorly tolerated in IPTp use.…”
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“…Serum and peritoneal 1.3-beta-d-glucan (sBDG and pBDG) have been proposed to confirm or invalidate the diagnosis of IAC, but clinical studies have reported inconsistent results, notably because of heterogeneous populations with a low IAC prevalence. …”
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“…The lack of evidence for an in situ association of IL-15 with TNF and IL-1 does not support a role for IL-15 in a proinflammatory cytokine 'cascade', as proposed by other in vitro experiments. We believe that sufficient evidence is available, however, to suggest that MC activation makes a significant contribution to the pathophysiological processes of the rheumatoid lesion.…”
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“…The results obtained from the second method employed to produce a lobar pneumonia offer suggestive evidence in support of a hematogenous causation of this disease in at least certain instances. It is not proposed to discuss the aerogenous versus hernatogenous theories at this time. …”
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“…The name virus encephalitis is proposed for the experimental disease produced in rabbits by the inoculation of the herpes and allied viruses.…”
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“…Dawson, as a result of detailed studies concerned with the dissociation of pneumococci (22) and of streptococci (23) has shown that these organisms have three variant forms and he proposes that the terminology currently employed for pneumococcal variants be changed to conform with the terms used in the description of corresponding variants of other bacterial species. …”
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“…Further, it makes unlikely the proposed extrapolation of such a model to other so-called thymus-independent antigens, e.g., PVP, levan, dextran, and SIII (19). …”
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“…Hence on the acid side of the optimum the addition of the same concentration of anion should have the same influence on the rate of digestion irrespective of whether it is combined with hydrogen or some other ion (provided, of course, that there is no other secondary effect of the other ion). The proposed mechanism is very similar to that suggested by Stieglitz and his coworkers for the hydrolysis of the imido esters. …”
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“…Homology, as applied to avian examples of apparent homologues, is considered in terms of recent theory, and a revised annotated classification of higher-order taxa of Neornithes and other closely related Theropoda is proposed. © 2007 The Linnean Society of London, Zoological Journal of the Linnean Society, 2007, 149, 1–95.…”
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“…The following new replacement name is proposed: Gompeliina Bouchard, 2011 nom. nov. for Olotelina Báguena Corella, 1948 (Aderidae). …”
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