Mostrando 1 - 20 Resultados de 34 Para Buscar '"The Strad"', tiempo de consulta: 0.39s Limitar resultados
  1. 1
    “…RESULTS: We find that STRADα is highly spliced and appears to be the primal STRAD paralog. …”
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    STRAD pseudokinases regulate axogenesis and LKB1 stability
  2. 2
    “…Here, we show that intracellular MDK interacts with LKB1 and STRAD to disrupt the LKB1-STRAD-Mo25 complex. Consequently, MDK decreases the activity of LKB1 to dampen both the basal and stress-induced activation of AMPK by glucose starvation or treatment of 2-DG. …”
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    Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex
  3. 3
    “…Here, we describe the structure of STRADα in complex with MO25α. The structure reveals an intricate web of interactions between STRADα and MO25α involving the αC-helix of STRADα, reminiscent of the mechanism by which CDK2 interacts with cyclin A. …”
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    ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
  4. 4
    “…We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADα, and MO25α, in 28 LKB1-negative PJS patients. …”
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    Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADα, and MO25α, in Peutz–Jeghers syndrome
  5. 5
    “…Third, catalytically active LKB1, STRADα or STRADβ and MO25α or MO25β are required for full activity. …”
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    Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
  6. 6
    “…A statistically significant increase in radial strain (STRAD) was observed in the CG: basal STRAD (57.4 ± 16.6 to 84.1 ± 30.9%, p < 0.05), medial STRAD (57.8 ± 27, 9 to 74.3 ± 36.1%, p < 0.05) and apical STRAD (38.2 ± 26.0 to 52.4 ± 29.8%, p < 0.01). …”
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    Influence of Aerobic Training on The Mechanics of Ventricular Contraction After Acute Myocardial Infarction: A Pilot Study
  7. 7
    “…Stk25 has been shown to bind to the LKB1 activator STRAD and regulate neuronal polarization and dendritogenesis in an opposing manner to Reelin-Dab1 signaling. …”
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    Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration
  8. 8
    por Argyropoulos, T, Dubourg, S, Trad, G
    Publicado 2019
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    8th Evian Workshop on LHC beam operation
  9. 9
    “…Co-immunoprecipitation analysis demonstrated that the 6-gingerol-elicited activation of an LKB1/AMPK pathway cascade was related to the enhanced stability of the LKB1/STRAD/MO25 complex. Furthermore, radicicol, an LKB1 destabilizer, inhibited the activating effect of 6-gingerol on an LKB1/AMPK pathway cascade via destabilizing LKB1/STRAD/MO25 complex stability in vitro, thus reversing the 6-gingerol-elicited ameliorative effect. …”
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    6-Gingerol Ameliorates Hepatic Steatosis, Inflammation and Oxidative Stress in High-Fat Diet-Fed Mice through Activating LKB1/AMPK Signaling
  10. 10
    por Fogarty, Sarah, Hardie, D. Grahame
    Publicado 2009
    “…Similarly, recombinant STRADα·MO25α complexes containing these LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2 in cell-free assays. …”
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    C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest
  11. 11
    “…MST and SPAK isoforms) as well as pseudokinases (e.g. STRAD isoforms that play a critical role in activating the LKB1 tumour suppressor). …”
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    Structural insights into the activation of MST3 by MO25
  12. 12
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    A modified two-slit interferometer for characterizing the asymmetric lateral coherence of undulator radiation
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    Two-dimensional electron beam size measurements with x-ray heterodyne near field speckles
  14. 14
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    Characterizing temporal coherence of visible synchrotron radiation with heterodyne near field speckles
  15. 15
    “…Co-expression of the LKB1 with the adaptor protein STRAD induces actin filament puncta associated with phospho-ezrin. …”
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    LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity
  16. 16
    por Kim, Yangjin
    Publicado 2013
    “…A microRNA, miR-451, and its downstream molecules, CAB39/LKB1/STRAD/AMPK, are known to play a critical role in regulating a biochemical balance between rapid proliferation and invasion in the presence of metabolic stress in microenvironment. …”
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    Regulation of Cell Proliferation and Migration in Glioblastoma: New Therapeutic Approach
  17. 17
    “…Subsequently, simulated thermal denaturation and docking studies were performed to determine their structural variations, which in turn alter the formation of active complex that comprises STK11, STRAD, and MO25. The deleterious effect of the mutants would result in a comparative loss of enzyme function due to variations in their binding energy pertaining to spatial conformation and flexibility. …”
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    Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach
  18. 18
    “…Expression analysis in the HepG2 and MCF7 cell lines demonstrated common expression of MST1/2/4, MAP4K3/4/5, STK 24 (MST3), STK25, STK39, Pak1, SLK, Stradα/β and TAO2. All components of the Hippo signaling pathway are present in both cell lines except for YAP1 in MCF7 cells. mTOR inhibition via rapamycin decreases TAZ levels in HepG2 but not MCF7 cells and increases TEAD1 levels in MCF7 but not HepG2 cells, suggesting a selective role of the mTOR pathway in regulating these Hippo targets in a cell type-specific manner. …”
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    Effects of mTOR Inhibitors on Components of the Salvador-Warts-Hippo Pathway
  19. 19
    “…Our data show, for the first time, a reduction in the levels of LKB1 and accessory proteins, MO25 and STRADα, in both mdx strains versus the respective wild type, which was further impaired by exercise, in parallel with a lack of further phosphorylation of AMPK. …”
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    LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model
  20. 20
    “…We describe a kinase pathway required for cell extrusion involving PAR-4, STRD-1 and MOP-25.1/2, the C. elegans homologs of the mammalian tumor suppressor kinase LKB1 and its binding partners STRADα and MO25α. The AMPK-related kinase PIG-1, a possible target of the PAR-4:STRD-1:MOP-25 kinase complex, is also required for cell shedding. …”
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    Programmed elimination of cells by caspase-independent cell extrusion in C. elegans
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