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  1. 2321
    “…The crystal structure of the C-terminal region of NavSulP grafted into the C-terminus of a NaK channel revealed that the NavSulP C-terminal region forms a four-helix bundle. …”
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    The C-terminal helical bundle of the tetrameric prokaryotic sodium channel accelerates the inactivation rate
  2. 2322
    por Poyurovsky, Masha V.
    Publicado 2012
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    Length matters: C-terminal tails regulate Mdm2–MdmX complexes
  3. 2323
    por Sabehi, Gazalah, Lindell, Debbie
    Publicado 2012
    “…These findings suggest that P-SSP7 is likely to use the direct terminal repeats for genome replication and packaging in a similar manner to other T7-like phages. …”
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    The P-SSP7 Cyanophage Has a Linear Genome with Direct Terminal Repeats
  4. 2324
    “…Two major isoforms of human SUFU are known, a full-length (SUFU-FL) and a carboxy-terminal truncated (SUFU- ΔC) variant. Even though SUFU- ΔC is expressed at an equivalent level as SUFU-FL in certain tissues, the function of SUFU-ΔC and its impact on HH signal transduction is still unclear. …”
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    Novel Mechanism of Action on Hedgehog Signaling by a Suppressor of Fused Carboxy Terminal Variant
  5. 2325
    “…Through extensive phenotypic analyses, we have characterized the systems-level consequences of one such mutation (rho*) in the global transcriptional terminator Rho of Escherichia coli. We find that a single amino acid change in Rho results in a massive change in the fitness landscape of the cell, with widely discrepant fitness consequences of identical single locus perturbations in rho* versus rho (WT) backgrounds. …”
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    Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator
  6. 2326
    “…The only difference in amino acid sequence between the isoforms is a 68-residue insert in the C-terminal tail domain of MV (MVt). Although the functional role of this insert remains elusive, its importance is exemplified by point mutations that are associated with dilated and hypertrophic cardiomyopathy. …”
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    The C-terminal tail domain of metavinculin, vinculin’s splice variant, severs actin filaments
  7. 2327
    “…We propose that the different subgenomic mRNA levels of coronaviruses are controlled through differential premature termination of transcription, and are modulated by the relative strength of transcriptional initiation/blockage events. …”
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    Differential premature termination of transcription as a proposed mechanism for the regulation of coronavirus gene expression.
  8. 2328
    “…RESULTS: The trial was terminated after the enrollment of six patients, due to an unexpected decline in serum immunoglobulin G (IgG) and the occurrence of serious infections. …”
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    Atacicept in combination with MMF and corticosteroids in lupus nephritis: results of a prematurely terminated trial
  9. 2329
    “…We report that the toxicity of NMDAR-mediated Ca(2+) influx is differentially controlled by the cytoplasmic C-terminal domains of GluN2B (CTD(2B)) and GluN2A (CTD(2A)). …”
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    The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults
  10. 2330
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    N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler
  11. 2331
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    Activation of Endogenous FAK via Expression of Its Amino Terminal Domain in Xenopus Embryos
  12. 2332
    “…Nuclear magnetic resonance (NMR) protein structure determination of an N-terminal 23–amino acid polypeptide of wild-type Cx43 revealed that it folded in to a kinked α-helical structure. …”
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    Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia
  13. 2333
    “…Photoreceptor terminals contain post-synaptic density (PSD) proteins e.g., PSD-95/PSD-93, but their role at photoreceptor synapses is not known. …”
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    Association of Shank 1A Scaffolding Protein with Cone Photoreceptor Terminals in the Mammalian Retina
  14. 2334
    “…INTRODUCTION: Involution of terminal duct lobular units (TDLUs), the structures that give rise to most breast cancers, has been associated with reduced breast cancer risk. …”
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    Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers
  15. 2335
    “…The facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. …”
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    Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations
  16. 2336
    “…Through engineering of two double-cysteine mVDAC1 variants we achieved fixing of the N-terminal segment at the bottom and midpoint of the pore. …”
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    Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior
  17. 2337
    “…In order to further explore the contributions of the C-terminal region of α-synuclein in fibril formation and also to understand the overall mechanism of fibril formation, we reduced the number of negatively charged residues in the C-terminal region using mutagenesis. …”
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    Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein
  18. 2338
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    Exploring pregnancy termination experiences and needs among Malaysian women: A qualitative study
  19. 2339
    “…These findings imply that labial is required in two specific neuroblast lineages of the wildtype brain for the appropriate termination of proliferation through programmed cell death. …”
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    The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain
  20. 2340
    “…Because the role of PTX3 in the cumulus resides in the unique N-terminal sequence of the protomer, we investigated further this issue by testing the ability of distinct Cys/Ser mutants of recombinant N-terminal region of PTX3 (N(_)PTX3) with different oligomeric arrangement to promote in vitro normal expansion in cumuli from Ptx3-null mice. …”
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    Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly
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