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  1. 3561
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    Modification and Targeted Design of N-Terminal Truncates Derived from Brevinin with Improved Therapeutic Efficacy
  2. 3562
    “…Here we define the molecular determinants that specify the interaction between BubR1 and CENP-E. The basic C-terminal helix of BubR1 is necessary but not sufficient for CENP-E interaction, and a minimal key acidic patch on the kinetochore-targeting domain of CENP-E is also essential. …”
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    The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment
  3. 3563
    “…Furthermore, it is not known whether terminal velocity used to characterize the primary dispersal capacity of diaspores can also be used to predict their secondary wind dispersal capacity. …”
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    Wing loading, not terminal velocity, is the best parameter to predict capacity of diaspores for secondary wind dispersal
  4. 3564
    “…In this report, we describe a patient with BRAF-mutated CRC who acquired an amino-terminal BRAF deletion involving the Ras-binding domain (RBD) after treatment with RAF/EGFR inhibitor therapy. …”
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    An amino-terminal BRAF deletion accounting for acquired resistance to RAF/EGFR inhibition in colorectal cancer
  5. 3565
    “…Clathrin is recruited to CCPs through interactions between the AP2 complex and its N-terminal domain, which in turn recruits endocytic accessory proteins. …”
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    Wbox2: A clathrin terminal domain–derived peptide inhibitor of clathrin-mediated endocytosis
  6. 3566
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    Zirconium‐Catalyzed Atom‐Economical Synthesis of 1,1‐Diborylalkanes from Terminal and Internal Alkenes
  7. 3567
    por Yao, Zhen, Buck, Manfred, Bühl, Michael
    Publicado 2020
    “…By using density functional theory calculations, the initial steps towards Pd metal cluster formation on a pyridine‐terminated self‐assembled monolayer (SAM) consisting of 3‐(4‐(pyridine‐4‐yl)phenyl)propane‐1‐thiol on an Au(1 1 1) surface are investigated. …”
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    Density Functional Theory Study of Pd Aggregation on a Pyridine‐Terminated Self‐Assembled Monolayer
  8. 3568
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    Active tyrosine phenol-lyase aggregates induced by terminally attached functional peptides in Escherichia coli
  9. 3569
    “…The 35 kDa OCP is structurally and functionally modular, consisting of an N-terminal effector domain (NTD) and a C-terminal regulatory domain (CTD); a carotenoid spans the two domains. …”
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    Structural analysis of a new carotenoid-binding protein: the C-terminal domain homolog of the OCP
  10. 3570
    “…Several BrS-associated mutations in the Na(v)1.5 N-terminal domain (NTD) exert a dominant-negative effect (DNE) on wild-type channel function, for which mechanisms remain poorly understood. …”
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    Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na(v)1.5
  11. 3571
    “…In this study, the design of an adaptive terminal sliding mode controller for the stabilization of port Hamiltonian chaotic systems with hidden attractors is proposed. …”
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    Stabilization of Port Hamiltonian Chaotic Systems with Hidden Attractors by Adaptive Terminal Sliding Mode Control
  12. 3572
    “…Here, the role of a member of the TERMINAL FLOWER 1/CENTRORADIALIS gene family (termed StCEN) in the negative control of tuberisation is demonstrated for what is thought to be the first time. …”
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    TERMINAL FLOWER‐1/CENTRORADIALIS inhibits tuberisation via protein interaction with the tuberigen activation complex
  13. 3573
    por Ueda, Sanae, Tamura, Naoki, Mima, Joji
    Publicado 2020
    “…Reconstituted membrane tethering assays with the C-terminally-truncated mutants of Rab4a further uncovered that the N-terminal residues in the HVR linker, located adjacent to the G-domain, are critical for regulating the intrinsic tethering activity. …”
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    Membrane Tethering Potency of Rab-Family Small GTPases Is Defined by the C-Terminal Hypervariable Regions
  14. 3574
    “…The carboxyl-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) exerts a neuroprotective effect in neurodegenerative diseases via the activation of signaling pathways related to neurotrophins, and also through inhibiting apoptotic cell death. …”
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    Neurotrophic Properties of C-Terminal Domain of the Heavy Chain of Tetanus Toxin on Motor Neuron Disease
  15. 3575
    “…The Ppz enzymes are Ser/Thr protein phosphatases present only in fungi that are characterized by a highly conserved C-terminal catalytic region, related to PP1c phosphatases, and a more divergent N-terminal extension. …”
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    The N-Terminal Region of Yeast Protein Phosphatase Ppz1 Is a Determinant for Its Toxicity
  16. 3576
    “…Our study reveals how NAT machineries have divergently evolved to N-terminally acetylate specific subsets of target proteins.…”
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    Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates
  17. 3577
    por Alaidarous, Mohammed
    Publicado 2020
    “…Here, using in silico physicochemical and homology modeling tools, we have reported the primary, secondary and tertiary structural characteristics of multiple N-terminal domains of selected bacterial TIR domain-containing proteins (Tcps). …”
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    In silico structural homology modeling and characterization of multiple N-terminal domains of selected bacterial Tcps
  18. 3578
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    Terminator or accelerator? Lessons from the peer-to-peer accommodation hosts in China in responses to COVID-19
  19. 3579
    “…The c-Jun-N-terminal kinase (JNK) is a critical mediator involved in various physiological processes, such as immune responses, and the pathogenesis of various diseases, including autoimmune disorders. …”
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    Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis
  20. 3580
    “…Mechanistic insights into intracellular toxin behavior have progressed significantly since it was shown that toxins exploit synaptic endocytosis for entry into the nerve terminal, but fundamental questions about host-toxin interactions remain unanswered. …”
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    Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals
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