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  1. 3961
    “…The interaction of the C-terminal region of UvrD with UvrB is therefore not an essential feature of the mechanism by which UvrD disassembles the post-incision complex during NER. …”
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    The unstructured C-terminal extension of UvrD interacts with UvrB, but is dispensable for nucleotide excision repair
  2. 3962
    “…This reveals an unprecedented link between nuclear RNA surveillance, the exosome and Pol II transcriptional termination.…”
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    A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination
  3. 3963
    “…Unlike mammalian Argonaute proteins, the Drosophila protein has an unusual amino-terminal domain made up largely of multiple copies of glutamine-rich repeats (GRRs). …”
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    Natural Variation of the Amino-Terminal Glutamine-Rich Domain in Drosophila Argonaute2 Is Not Associated with Developmental Defects
  4. 3964
    “…In addition, nuclear localization of MKS1 was shown to depend on an intact N-terminal domain. Furthermore, loss-of-function mks1 mutants exhibited increased susceptibility to strains of Pseudomonas syringae and Hyaloperonospora arabidopsidis, indicating that MKS1 plays a role in basal defense responses. …”
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    Arabidopsis MKS1 Is Involved in Basal Immunity and Requires an Intact N-terminal Domain for Proper Function
  5. 3965
    “…We investigated the poorly understood mechanism of plasma membrane targeting of mDia2 and found that the entire N-terminal region of mDia2 preceding the actin-polymerizing formin homology domains 1 and 2 (FH1–FH2) module was potently targeted to the membrane. …”
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    Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains
  6. 3966
    “…METHODOLOGY/PRINCIPAL FINDINGS: Overexpression of Hec1 could never be obtained in HeLa clones inducibly expressing C-terminally tagged Hec1 or untagged Hec1, suggesting that Hec1 cellular levels are tightly controlled. …”
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    Abnormal Kinetochore-Generated Pulling Forces from Expressing a N-Terminally Modified Hec1
  7. 3967
    “…CONCLUSIONS: This has been the first report where a terminally attached self-assembling β peptide ELK16 can promote the formation of active inclusion bodies or active protein aggregates in E. coli. …”
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    Active protein aggregates induced by terminally attached self-assembling peptide ELK16 in Escherichia coli
  8. 3968
    “…Moreover, our data clearly illustrate the smooth adaptation of temporal gaze-hand coordination to terminal accuracy requirements during fast reciprocal pointings. …”
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    Effect of terminal accuracy requirements on temporal gaze-hand coordination during fast discrete and reciprocal pointings
  9. 3969
    “…Since Pol I transcribes rDNA repeats with high processivity and polymerase density, transcription termination is a critical process. Early in vitro studies proposed polymerase pausing by Reb1 and transcript release at the T-rich element T1 determined transcription termination. …”
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    Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I
  10. 3970
    “…METHODS: A recombinant VP19c (rVP19c) and N-terminal were expressed in Escherichia coli (E.coli) and purified by Ni2+-affinity chromatography. …”
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    Expression and characterization of recombinant VP19c protein and N-terminal from duck enteritis virus
  11. 3971
    “…SAXS, comparative modeling and SEC-MALS analysis revealed that hNek6 is a monomeric kinase of slightly elongated shape and a short unfolded N-terminal domain.…”
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    Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain
  12. 3972
    “…Sequence analysis revealed the presence of 8 conserved cysteine residues in the C-terminal cytoplasmic domain of this protein suggesting these residues form a zinc-coordinating RING finger structure. …”
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    Fertilization in C. elegans requires an intact C-terminal RING finger in sperm protein SPE-42
  13. 3973
    “…Finally, with timed administration of nucleoside analogs we demonstrate that the Insm1 mutants contain fewer terminally dividing progenitors at embryonic day 12.5. …”
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    Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic
  14. 3974
    “…While protein functions have been extensively studied, the substantial amino-terminal region (NTR*) of MSH6 that is unique to eukaryotic proteins, has mostly evaded functional characterization. …”
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    Cooperative Nuclear Localization Sequences Lend a Novel Role to the N-Terminal Region of MSH6
  15. 3975
    “…Our data support causal links between these mutations and disease; they demonstrate that mutations affecting the N-terminal activities of FH, not just those in the C terminus, can predispose to aHUS. …”
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    Disease-associated N-terminal Complement Factor H Mutations Perturb Cofactor and Decay-accelerating Activities
  16. 3976
    “…Using an anti-Ptc1 C-terminal domain antibody, we provide conclusive evidence that C-terminal fragments of endogenous Ptc1 accumulate in the nucleus of C3H10T1/2 cells. …”
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    A Novel Signaling Pathway Mediated by the Nuclear Targeting of C-Terminal Fragments of Mammalian Patched 1
  17. 3977
    “…The structure of the C-terminal domain of SpaP (residues 1136–1489) was solved and refined to 2.2 Å resolution with six molecules in the asymmetric unit. …”
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    Structure of the C-terminal domain of the surface antigen SpaP from the caries pathogen Streptococcus mutans
  18. 3978
    “…We demonstrate that extracts depleted of Ndel1 are unable to form asters and that this defect can be rescued by the addition of recombinant N-terminal coiled-coil domain of Ndel1. Ndel1-dependent microtubule self-organization requires an interaction between Ndel1 and dynein, which is mediated by the dimerization fragment of the coiled-coil. …”
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    The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein
  19. 3979
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    Evidence for the existence of pathogenicity determinants in the Long Terminal Repeats (LTRs) of the Bovine Leukemia Virus (BLV) genome
  20. 3980
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    The N-Terminal Amphipathic Helix of the Topological Specificity Factor MinE Is Associated with Shaping Membrane Curvature
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