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4081
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4082por Ramkumar, Srinivasagan, Fujii, Noriko, Fujii, Norihiko, Thankappan, Bency, Sakaue, Hiroaki, Ingu, Kim, Natarajaseenivasan, Kalimuthusamy, Anbarasu, Kumarasamy“…METHODS: Alpha A crystallin N-terminal mutants were created with the site-directed mutagenesis method. …”
Publicado 2014
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4083
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4084por Chu, Yu-De, Wang, Wei-Chieh, Chen, Shi-An A, Hsu, Yen-Ting, Yeh, Meng-Wei, Slack, Frank J, Chan, Shih-Peng“…The let-7 microRNA (miRNA) regulates cell cycle exit and terminal differentiation in the C. elegans heterochronic gene pathway. …”
Publicado 2014
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4085
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4086por Ide, Satomi, Kiyosue, Hiro, Tanoue, Shuichi, Okahara, Mika, Sagara, Yoshiko, Hori, Yuzo, Mori, Hiromu“…INTRODUCTION: The aim of the study was to investigate the variations in the uncal vein (UV) termination and its clinical implication in cavernous sinus dural arteriovenous fistulas (CSDAVFs). …”
Publicado 2014
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4087por Cai, Yiying, Deng, Yongqiang, Horenkamp, Florian, Reinisch, Karin M., Burd, Christopher G.“…We present a characterization of the structure of the N-terminal portion of yeast Sac1, containing the conserved Sac1 homology domain, in complex with Vps74, a phosphatidylinositol 4-kinase effector and the orthologue of human GOLPH3. …”
Publicado 2014
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4088“…In vertebrate sHSPs the poorly structured N-terminal domain has been implicated in both chaperone activity and the formation of higher-order oligomers. …”
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4089“…Here, we explore further the important features of the N-terminal sequence and investigate what variations in the CXXCH residues are productively recognised by HCCS in its substrate.…”
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4090por Lovett, David H., Chu, Charles, Wang, Guanying, Ratcliffe, Mark B., Baker, Anthony J.“…Recently, a novel N-terminal truncated MMP-2 isoform (NTT-MMP-2) generated during oxidative stress was identified and shown to induce severe systolic failure; however, the injury mechanisms remained unclear. …”
Publicado 2014
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4091“…METHODS: To study the role of the N-terminus of NP aside from NLS function, we generated an N-terminal NP deletion mutant, del20NLS-NP, encoding the conventional SV40 T-antigen NLS in place of the first 20 amino acids of NP. …”
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4092“…This goal has been elusive, however, due to the complex interplay of global and local events as well as missing structural data on LeuT N-terminal segment. We provide here for the first time a comprehensive description of the molecular events leading to substrate/Na(+) release to the postsynaptic cell, including the structure and dynamics of the N-terminal segment using a combination of molecular simulations. …”
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4093“…AIM/INTRODUCTION: Circulating levels of N-terminal fragment of probrain natriuretic peptide (NT-proBNP) are established as a risk factor for cardiovascular disease and mortality in patients with diabetes, as well as in the general population. …”
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4094por Ma, Yinghuan, Bao, Yongxin, Li, Chenghao, Jiao, Fubin, Xin, Hongjie, Yuan, Zhengwei“…There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. …”
Publicado 2012
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4095“…[Image: see text] We report the evolution of electrical transport and grain size during the sintering of thin films spin-cast from soluble phosphine and amine-bound, chloride-terminated cadmium selenide nanocrystals. Sintering of the nanocrystals occurs in three distinct stages as the annealing temperature is increased: (1) reversible desorption of the organic ligands (≤150 °C), (2) irreversible particle fusion (200–300 °C), and (3) ripening of the grains to >5 nm domains (>200 °C). …”
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4096“…Computational experiments on a specific railway container terminal are conducted to illustrate the proposed model and solution algorithm. …”
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4097por Wong, C, Laddha, S V, Tang, L, Vosburgh, E, Levine, A J, Normant, E, Sandy, P, Harris, C R, Chan, C S, Xu, E Y“…Recently inhibitors of bromodomain and extra-terminal (BET) family proteins have shown antitumor effects through the suppression of MYC in leukemia and lymphoma. …”
Publicado 2014
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4098por Morishima-Kawashima, Maho“…Aβ is generated through intramembrane proteolysis of the β-carboxyl terminal fragment (βCTF) of β-amyloid precursor protein (APP) by γ-secretase. …”
Publicado 2014
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4099“…Aβ is produced by β- and γ-cleavages of amyloid β precursor protein (APP). Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme that cleaves ubiquitin at its carboxyl terminal. …”
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4100por Fernández-Fueyo, Elena, Acebes, Sandra, Ruiz-Dueñas, Francisco J., Martínez, María Jesús, Romero, Antonio, Medrano, Francisco Javier, Guallar, Victor, Martínez, Angel T.“…The genome of Ceriporiopsis subvermispora includes 13 manganese peroxidase (MnP) genes representative of the three subfamilies described in ligninolytic fungi, which share an Mn(2+)-oxidation site and have varying lengths of the C-terminal tail. Short, long and extralong MnPs were heterologously expressed and biochemically characterized, and the first structure of an extralong MnP was solved. …”
Publicado 2014
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