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  1. 4181
    “…Here we have applied quantitative phosphoproteomics to identify changes in phosphorylation status of presynaptic proteins in resting and stimulated nerve terminals isolated from the brains of Wistar rats. …”
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    Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis
  2. 4182
    “…BACKGROUND: Teenage pregnancy is a global social health concern especially because of the HIV and AIDS pandemic, sexually transmitted infections, high rate of termination of pregnancy (TOP), adolescents’ parenthood and decreased level of contraceptives. …”
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    Views of teenagers on termination of pregnancy at Muyexe high school in Mopani District, Limpopo Province, South Africa
  3. 4183
    “…The roles of three key C-terminal regions in subcellular localization of CaHV GPCR were determined. …”
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    Mutations in the C-terminal region affect subcellular localization of crucian carp herpesvirus (CaHV) GPCR
  4. 4184
    “…In vertebrates, the C-terminal portion of TFPI-2 consists of a highly conserved cluster of positively charged amino acids which may point to an antimicrobial activity. …”
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    Vertebrate TFPI-2 C-terminal peptides exert therapeutic applications against Gram-negative infections
  5. 4185
    “…To investigate whether the mitochondrial apoptotic pathway mediates myocardial cell injuries in rats under brain death (BD), and observe the effects and mechanisms of the c‐Jun N‐terminal kinase (JNK) inhibitor SP600125 on cell death in the heart. …”
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    Myocardial protective effects of a c‐Jun N‐terminal kinase inhibitor in rats with brain death
  6. 4186
    “…Investigation of long-range intra- and interdomain communications in the p53 tetramer–DNA complex was performed by means of an atomistic model that included the tetramerization helices in the C-terminal domain, the DNA-binding domains and a consensus DNA-binding site of 18 base pairs. …”
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    The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain
  7. 4187
    “…We use atomic force microscopy to investigate the functional roles of the N-terminal domain and the C-terminal domain that show different patterns of sequence conservation. …”
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    The Contributions of the Amino and Carboxy Terminal Domains of Flightin to the Biomechanical Properties of Drosophila Flight Muscle Thick Filaments
  8. 4188
    “…However, only N-terminal RRM (RRM1) was crystallized and its structure was determined at 1.7 Å resolution. …”
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    Crystal Structure of the N-Terminal RNA Recognition Motif of mRNA Decay Regulator AUF1
  9. 4189
    “…BACKGROUND: Dysfunctions of the ubiquitin proteasome system (UPS), including the highly abundant neuronal enzyme ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), and autophagy-related changes (lysosomal degradation) are implicated in several neurodegenerative disorders including Alzheimer's disease (AD). …”
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    Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease
  10. 4190
    “…Furthermore, we found that the N-terminal 263 aa of PP (PP(N-263)) determined its shut-off activity using the expression of truncated proteins. …”
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    N-Terminal Domain of Feline Calicivirus (FCV) Proteinase-Polymerase Contributes to the Inhibition of Host Cell Transcription
  11. 4191
    por Rijal, Keshab, Maraia, Richard J.
    Publicado 2016
    “…The ability of RNA polymerase (RNAP) III to efficiently recycle from termination to reinitiation is critical for abundant tRNA production during cellular proliferation, development and cancer. …”
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    Active Center Control of Termination by RNA Polymerase III and tRNA Gene Transcription Levels In Vivo
  12. 4192
    “…N-terminal acetylation is a highly abundant protein modification catalyzed by N-terminal acetyltransferases (NATs) NatA-NatG. …”
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    Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases
  13. 4193
    “…In this study, we determined the crystal structure of a catalytically active form of DUSP26 (residues 39–211, DUSP26-N) with an additional N-terminal region at 2.0 Å resolution. Unlike the C-terminal domain-swapped dimeric structure of DUSP26-C, the DUSP26-N (C152S) monomer adopts a fold-back conformation of the C-terminal α8-helix and has an additional α1-helix in the N-terminal region. …”
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    Structural Insight into the Critical Role of the N-Terminal Region in the Catalytic Activity of Dual-Specificity Phosphatase 26
  14. 4194
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    Increased expression of Trpv1 in peripheral terminals mediates thermal nociception in Fabry disease mouse model
  15. 4195
    “…PCC 6803 to eliminate the N-terminal cysteinyl residue, preventing lipid modification. …”
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    N-Terminal Lipid Modification Is Required for the Stable Accumulation of CyanoQ in Synechocystis sp. PCC 6803
  16. 4196
    “…The present study provides the first description of two monoclonal antibodies (mAbs) (5E8 and 3D7) directed against the TGEV N protein linker region (LKR) and carboxyl terminal domain (CTD). The mAbs 5E8 and 3D7 reacted with native N protein in western blotting and immunofluorescence assay (IFA). …”
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    Characterization of Two Monoclonal Antibodies That Recognize Linker Region and Carboxyl Terminal Domain of Coronavirus Nucleocapsid Protein
  17. 4197
    “…The histone 3 lysine 9 methyltransferase Setdb1 is essential for both stem cell pluripotency and terminal differentiation of different cell types. To shed light on the roles of Setdb1 in these mutually exclusive processes, we used mouse skeletal myoblasts as a model of terminal differentiation. …”
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    Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation
  18. 4198
    “…BACKGROUND: Severe hand, foot, and mouth disease (HFMD) is sometimes associated with serious complications such as acute heart failure that can cause substantial child mortality. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a sensitive and specific biomarker of congestive heart failure. …”
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    N-terminal pro-brain natriuretic peptide levels associated with severe hand, foot and mouth disease
  19. 4199
    “…We report 5 patients with SHORT syndrome and C-terminal mutations in PIK3R1, encoding the p85α/p55α/p50α subunits of PI3K, which act between INSR and AKT in insulin signaling. …”
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    Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations
  20. 4200
    por Liu, Dongsheng, Cowburn, David
    Publicado 2016
    “…The SH2 domain of C-terminal Src kinase (Csk) contains a single disulfide bond, which is unusual for most SH2 domains. …”
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    Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase
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