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  1. 86201
    “…CONCLUSION: Laparoscopic ovariectomy enables elective termination of pregnancy and simultaneous neutering of dogs in late gestation and has potential applications in high volume stray dog sterilization programs which utilize laparoscopy. …”
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    Laparoscopic ovariectomy in dogs in late gestation
  2. 86202
    “…WHO recommends waiting at least 2 years after a live birth and 6 months after miscarriage or induced termination before conception of another pregnancy. …”
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    Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: protocol for an international cohort study
  3. 86203
    “…TAK-875 (fasiglifam), a GPR40 agonist in development for the treatment of type 2 diabetes (T2D), was voluntarily terminated in Phase III trials due to adverse liver effects. …”
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    Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury
  4. 86204
    “…Here we explore the attitude of Israeli physicians to two debatable dilemmas: disclosing the full truth to patients about a poor medical prognosis, and assisting terminally ill patients in ending their lives. METHODS: Attitudes towards medico-ethical dilemmas were examined through a nationwide online survey conducted among members of the Israeli Medical Association, yielding 2926 responses. …”
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    Truth-telling and doctor-assisted death as perceived by Israeli physicians
  5. 86205
    “…The primary outcome was change in Adult Itch Reported Outcome (ItchRO™) average weekly sum score (0, no itching; 70, maximum itching) from baseline to week 13/early termination (ET). The study enrolled 66 patients (maralixibat [both doses combined], n = 42; placebo, n = 24). …”
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    A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis
  6. 86206
    “…Podocyte loss is one of the determining factors for the progression toward glomerulosclerosis. Podocyte is terminally differentiated and does not typically proliferate following injury and loss. …”
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    Inhibiting 4E-BP1 re-activation represses podocyte cell cycle re-entry and apoptosis induced by adriamycin
  7. 86207
    “…The trial was not sufficiently powered to reach statistical significance due to early termination. Nevertheless, the study provides important insights in the feasibility of a limited-excision and could serve as a pilot study for future trials. …”
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    A randomized trial comparing limited-excision conisation to Large Loop Excision of the Transformation Zone (LLETZ) in cervical dysplasia patients
  8. 86208
    “…In addition to commercial assays, novel measures capturing N-terminus+mid-domain (tau N-Mid) and C-terminally truncated (tau-368) fragments were included. …”
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    Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer’s disease
  9. 86209
    “…Reduction in spinal MOR binding sites and loss in MOR immunoreactivity of nerve terminals in the spinal cord and dorsal root ganglia in diabetic rats were observed. …”
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    Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats
  10. 86210
    “…We will conduct a meta-analysis adding these data to evaluate the effects of dexmedetomidine on delirium and mortality in ICU patients, aiming to terminate controversy and provide robust evidence for guiding clinical practice. …”
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    Effects of dexmedetomidine on delirium and mortality during sedation in ICU patients: a systematic review and meta-analysis protocol
  11. 86211
    “…The detection of Hypoderma on cattle was terminated when warbles were no longer emerging. RESULTS: All intact larvae collected were identified as H. lineatum. …”
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    LONGRANGE® (eprinomectin 5% w/v extended-release injection) efficacy against Hypoderma lineatum in an endemic area in southern Italy
  12. 86212
    “…RESULTS: The RFNs efficiently disrupted bcr-abl and prematurely terminated its translation. The destruction of bcr-abl gene suppressed cell proliferation and induced cell apoptosis in CML lines and in CML stem/progenitor cells. …”
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    Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells
  13. 86213
    “…This study started in July 2017. Follow-up will terminate after 5 years from the time when the last patient was enrolled. …”
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    Robot-assisted esophagectomy (RAE) versus conventional minimally invasive esophagectomy (MIE) for resectable esophageal squamous cell carcinoma: protocol for a multicenter prospective randomized controlled trial (RAMIE trial, robot-assisted minimally invasive Esophagectomy)
  14. 86214
    “…An interval of 30 min between each dose of albuterol, with spirometry measured at baseline and after each inhalation. Titration will be terminated if forced expiratory volume in 1 s improvement is <5%, or adverse event is observed. …”
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    Effects of flow rate on transnasal pulmonary aerosol delivery of bronchodilators via high-flow nasal cannula for patients with COPD and asthma: protocol for a randomised controlled trial
  15. 86215
    “…These CD8 T cells exhibit stem-like properties undergoing self-renewal and also differentiating into the terminally exhausted CD8 T cells. Here we compared the epigenetic signature of stem-like CD8 T cells with exhausted CD8 T cells. …”
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    Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade
  16. 86216
    “…RESULTS: At M6, individuals receiving palifermin had fewer naive CD4(+) T cells (2.229 × 10(7)/l vs. 7.733 × 10(7)/l; P = 0.007), RTEs (16% vs. 34%), and sjTRECs/ml (1100 vs. 3396), leading to protocol-defined termination of recruitment. No difference was observed in the rate of autoimmunity between the 2 groups. …”
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    Keratinocyte growth factor impairs human thymic recovery from lymphopenia
  17. 86217
    “…TRA2B exon 2 encodes multiple premature termination codons. TRA2β1 lacks exon 2 and is translated into a functional transformer 2β (Tra2β) protein, whereas TRA2β4 contains 10 exons and works as a functional RNA. …”
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    HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells
  18. 86218
    “…RESULTS: Although participants with and without comorbid personality disorder improved at treatment termination (d = 1.04, 95% CI 0.77–1.31 and d = 1.36, 95% CI 0.97–1.76, respectively) and at follow-up (d = 1.15, 95% CI 0.87–1.43 and d = 2.12, 95% CI 1.65–2.59 respectively), personality disorder had a negative effect on depression outcome at both measurement points (P < 0.05). …”
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    The effect of comorbid personality disorder on depression outcome after short-term psychotherapy in a randomised clinical trial
  19. 86219
    “…HFC administration after CPB termination significantly improved FIBTEM MCF by 2.6 mm (p < 0.001). …”
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    Interval changes in ROTEM values during cardiopulmonary bypass in pediatric cardiac surgery patients
  20. 86220
    “…This resulted in a frameshift leading to premature termination codon within exon 7 (p.(Asp265Thrfs*10)). …”
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    Characterization of the c.793-1G > A splicing variant in CHEK2 gene as pathogenic: a case report
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