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  1. 86401
    “…These findings reveal that MORs are expressed in presynaptic PF axon terminals, where DAMGO can activate presynaptic MORs to inhibit PF-PC synaptic transmission by regulating the release of glutamate. …”
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    Mechanisms Underlying Mu Opioid Receptor Effects on Parallel Fiber-Purkinje Cell Synaptic Transmission in Mouse Cerebellar Cortex
  2. 86402
    “…In contrast, 20 Hz activity induced by a 1-s pulse applied every 5–10 s caused only a transient facilitation of Ih inhibition followed by a forced termination of Ih inhibition. Thus, the three modes of LC activities modulated the volume transmission to activate α(2)-adrenergic GPCR to differentially inhibit Ih in MTN neurons.…”
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    The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons
  3. 86403
    “…The provision of remote care to a terminally ill patient is associated with specific challenges and burdens. …”
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    Long-distance caregiving at the end of life: a protocol for an exploratory qualitative study in Germany
  4. 86404
    “…Utilising nanopore cDNA sequencing, we found a strong correlation between the inclusion of intronic TEs in gene transcripts and the presence of premature termination codons in these transcripts. Finally, we identified low levels of full-length transcripts deriving from structurally intact TE loci in the grapevine model. …”
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    Comprehensive analysis of both long and short read transcriptomes of a clonal and a seed-propagated model species reveal the prerequisites for transcriptional activation of autonomous and non-autonomous transposons in plants
  5. 86405
    “…Detection of rVSV-ΔG-SARS-CoV-2-S vaccine RNA was noted in the regional iliac lymph node in animals assigned to the high-dose group, at both termination time points. A significant increase in binding and neutralizing antibody titers was observed following vaccination at both vaccine doses. …”
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    rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits
  6. 86406
    “…This intermediate is subsequently hydroxylated by deoxyhypusine hydroxylase (DOHH) to form hypusine in eIF5A. eIF5A, DHPS, and DOHH are highly conserved in all eukaryotes, and both enzymes exhibit a strict specificity toward eIF5A substrates. eIF5A promotes translation elongation globally by alleviating ribosome stalling and it also facilitates translation termination. Hypusine is required for the activity of eIF5A, mammalian cell proliferation, and animal development. …”
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    Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment
  7. 86407
    “…The frameshift mutation resulted in a loss of function by yielding a premature termination of 28 residues at the C-terminus of the protein. …”
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    ATP6V0C Is Associated With Febrile Seizures and Epilepsy With Febrile Seizures Plus
  8. 86408
    “…The main outcomes were the duration of analgesia and the duration of sensory blockade separately for each nerve termination of the upper limb, and the duration of motor blockade of the upper limb. …”
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    Dexmedetomidine prolongs the duration of local anesthetics when used as an adjuvant through both perineural and systemic mechanisms: a prospective randomized double-blinded trial
  9. 86409
    “…In the staged study design, an interval evaluation after 11 patients invokes study termination if safety events occur above the allowed threshold. …”
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    Percutaneous transuterine fetal cerebral embolisation to treat vein of Galen malformations at risk of urgent neonatal decompensation: study protocol for a clinical trial of safety and feasibility
  10. 86410
    “…Best overall response was stable disease in 13/25 response-evaluable patients. The study was terminated early as data collected were considered sufficient to evaluate safety and immunogenicity. …”
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    Safety and preliminary immunogenicity of JNJ-64041809, a live-attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer
  11. 86411
    “…Patients were administered the following treatment regimen: 20 mg/d avatrombopag; if the PLT count was less than 50×10(^)9/L for at least 2 weeks, the dose was increased to 40 mg/d; if the PLT count was 200-400×10(^)9/L, the dose was reduced; and if the PLT count was greater than 400×10^9/L, avatrombopag was terminated. Umbilical cord MSCs (1×10(^)6 cells/kg) infusion was performed every week for 4-6 weeks. …”
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    Analysis of the Efficacy and Safety of Avatrombopag Combined With MSCs for the Treatment of Thrombocytopenia After Allogeneic Hematopoietic Stem Cell Transplantation
  12. 86412
    “…Preference for home death should be considered when managing terminally ill geriatric patients.…”
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    Symptom Prevalence and Place of Death Preference in Advanced Cancer Patients: Factors Associated With the Achievement of Home Death
  13. 86413
    “…We hypothesized that AQP4-IgG production in germinal centers (GCs) was a core feature of NMOSDs and could be terminated by rituximab. To investigate this directly, deep cervical lymph node (dCLN) aspirates (n = 36) and blood (n = 406) were studied in a total of 63 NMOSD patients. …”
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    Rituximab abrogates aquaporin-4–specific germinal center activity in patients with neuromyelitis optica spectrum disorders
  14. 86414
    “…BACKGROUND: Hepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally truncated middle surface protein (MHBSt) has been reported to contribute to HCC through transcriptional activation in epidemiology studies, while the underlying mechanism of MHBSt-induced HCC is unknown. …”
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    MHBSt(167) induced autophagy promote cell proliferation and EMT by activating the immune response in L02 cells
  15. 86415
    “…Plasma STZ concentrations decreased rapidly after termination of infusion, with a half-life of 32–40 min. …”
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    Phase I/II study of streptozocin monotherapy in Japanese patients with unresectable or metastatic gastroenteropancreatic neuroendocrine tumors
  16. 86416
    “…PC death risk was increased in the following groups: nontesting men, men entering the program after age 60 and men with >10 years of followup after screening termination. CONCLUSIONS: Prostate specific antigen-based screening substantially decreases PC mortality. …”
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    Results from 22 years of Followup in the Göteborg Randomized Population-Based Prostate Cancer Screening Trial
  17. 86417
    “…Given the slow case registration and safety concerns in the combination group, the trial was terminated without extending the registration. The incidence of a ≥5% relative decline in FVC during the first 6 months was 50.0% in the switch group and 66.7% in the combination group. …”
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    Randomized phase II study of nintedanib with or without pirfenidone in patients with idiopathic pulmonary fibrosis who experienced disease progression during prior pirfenidone administration
  18. 86418
    “…Median survival from end of radiotherapy was 3 months (95% CI 4.3–21.7 weeks, range 0–72 weeks), with 25.6% (n = 11) early termination of treatment and 83.7% (n = 36) requiring radiotherapy as in-patients. …”
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    Radiotherapy for glioblastoma patients with poor performance status
  19. 86419
    “…Of the remaining 15 trials, 5 were terminated early and 7 of the 10 completed trials enrolled fewer patients than planned or did not report the planned sample size. …”
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    Challenges and complexities in designing cluster headache prevention clinical trials: A narrative review
  20. 86420
    “…In SYMP COVID-19 patients, the T cell compartment displays several alterations involving naive, central memory, effector memory, and terminally differentiated T cells. The senescence CD57 marker was highly expressed on CD8(+) T(EM) cells and CD8(+) T(EMRA) cells. …”
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    High Frequencies of Phenotypically and Functionally Senescent and Exhausted CD56(+)CD57(+)PD-1(+) Natural Killer Cells, SARS-CoV-2-Specific Memory CD4(+) and CD8(+) T cells Associated with Severe Disease in Unvaccinated COVID-19 Patients
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