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88481“…There were 51 singleton live births, 2 miscarriages, 9 terminations and 5 continuing to term. In 17 live births to women not on ART at conception, median gestational age at start of ART was 17 weeks (range 3–29). …”
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88482por Portelius, Erik, Dean, Robert A, Andreasson, Ulf, Mattsson, Niklas, Westerlund, Anni, Olsson, Maria, Demattos, Ronald Bradley, Racke, Margaret M, Zetterberg, Henrik, May, Patrick C, Blennow, Kaj“…By independent measurement techniques, we also show that BACE1 inhibition in humans is associated with APP-processing into N-terminally truncated Aβ peptides via a BACE1-independent pathway. …”
Publicado 2014
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88483por Barisic, Ingeborg, Boban, Ljubica, Greenlees, Ruth, Garne, Ester, Wellesley, Diana, Calzolari, Elisa, Addor, Marie-Claude, Arriola, Larraitz, Bergman, Jorieke EH, Braz, Paula, Budd, Judith LS, Gatt, Miriam, Haeusler, Martin, Khoshnood, Babak, Klungsoyr, Kari, McDonnell, Bob, Nelen, Vera, Pierini, Anna, Queisser-Wahrendorf, Annette, Rankin, Judith, Rissmann, Anke, Rounding, Catherine, Tucker, David, Verellen-Dumoulin, Christine, Dolk, Helen“…In 55% (11/20) of prenatally detected cases, parents decided to terminate pregnancy. Thumb anomalies were reported in all cases. …”
Publicado 2014
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88484por Zhang, Qian, Yuan, Wei, Wang, Guoxing, Wu, Junyuan, Wang, Miaomiao, Li, ChunSheng“…ISF was collected continuously, and the experiment was terminated 24 hours after resuscitation. RESULTS: After 8 minutes of untreated VF, the sildenafil group exhibited higher glucose and pyruvate concentrations of ISF and lower lactate and glutamate levels in comparison with the SA group, and these data reached statistical significance (P < 0.05). …”
Publicado 2014
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88485por Ryvlin, Philippe, Gilliam, Frank G, Nguyen, Dang K, Colicchio, Gabriella, Iudice, Alfonso, Tinuper, Paolo, Zamponi, Nelia, Aguglia, Umberto, Wagner, Louis, Minotti, Lorella, Stefan, Hermann, Boon, Paul, Sadler, Mark, Benna, Paolo, Raman, Pradheep, Perucca, Emilio“…The study was prematurely terminated due to recruitment difficulties prior to completing the planned enrollment of n = 362. …”
Publicado 2014
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88486“…Moreover, by simplifying the generation of learning curves, CDM enables study coordinators to assess more accurately when data collection can be terminated, resulting in better models or lower patient recruitment costs.…”
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88487por Lv, Honghao, Fang, Zhiyuan, Yang, Limei, Zhang, Yangyong, Wang, Qingbiao, Liu, Yumei, Zhuang, Mu, Yang, Yuhong, Xie, Bingyan, Liu, Bo, Liu, Jisheng, Kang, Jungen, Wang, Xiaowu“…For re-Bol037156, we found high identity among the sequences of the resistant lines, while among the susceptible lines, there were two types of InDels (a 1-bp insertion and a 10-bp deletion), each of which caused a frameshift and terminating mutation in the cDNA sequences. Further sequence analysis of the two InDel loci from 80 lines (40 resistant and 40 susceptible) also showed that all 40 R lines had no InDel mutation while 39 out of 40 S lines matched the two types of loci. …”
Publicado 2014
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88488“…In the other transgenic line, the omega-5 gliadins were absent and there was a partial reduction in the levels of the omega-1,2 gliadins and the omega-1,2 chain-terminating gliadins as well as small changes in several other proteins. …”
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88489por Wang, Pengfei, Xia, Han, Zhang, Ye, Zhao, Shuzhen, Zhao, Chuanzhi, Hou, Lei, Li, Changsheng, Li, Aiqin, Ma, Chuanxi, Wang, Xingjun“…The promoter sequence and transcriptional termination region (TTR) were more methylated than the gene body (intron and exon) region based on peak number and methylated depth. …”
Publicado 2015
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88490“…We found that the putative MrpC binding sites revealed by ChIP-seq are enriched for DNA sequences that strongly resemble a consensus sequence for MrpC binding proposed previously. MrpC2, an N-terminally truncated form of MrpC, bound to DNA sequences matching the consensus in all 11 cases tested. …”
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88491“…Animals were monitored progressively for weight gain and blood and livers were harvested at termination. The extent of liver injury was examined by histopathology as well as by liver and serum biochemistry. …”
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88492“…Twenty-one neonates undergoing surgery for congenital heart disease at >7 days after birth were randomly allocated to two groups: group A received 3 × 10(9) colony-forming units (CFU)/day of enteral B. breve strain Yakult (BBG-01), which was started 1 week before and terminated 1 week after surgery (n = 10), and group B did not receive BBG-01 (n = 11). …”
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88493por Zhou, Yanfang, Li, Jiemei, Lu, Fang, Deng, Junjie, Zhang, Jiahua, Fang, Peijie, Peng, Xinsheng, Zhou, Shu-Feng“…Recently, we have introduced alkyne-terminated poly(amidoamine) (PAMAM) dendrons of different generations (G=2,3) into chitosan to obtain dendronized chitosan derivatives [Cs-g-PAMAM (G=2,3)], which exhibited a better water solubility and enhanced plasmid DNA transfection efficiency. …”
Publicado 2015
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88494“…RESULTS: The milnacipran program was terminated early due to low enrollment. Because only 20 patients were randomized into the double-blind withdrawal period, statistical analyses were not conducted for the LTR endpoint. …”
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88495por Hilton, Hugo G., Norman, Paul J., Nemat-Gorgani, Neda, Goyos, Ana, Hollenbach, Jill A., Henn, Brenna M., Gignoux, Christopher R., Guethlein, Lisbeth A., Parham, Peter“…Mutation of KIR2DL1*012 gave rise to KIR2DL1*026, causing premature termination of translation at the end of the transmembrane domain. …”
Publicado 2015
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88496“…The frame shift mutation was predicted to cause a premature termination codon. In a larger cohort, this mutation, TTC8(c.669delA), segregates correctly in 22 out of 29 cases tested (75.9%). …”
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88497por Munemoto, Yoshinori, Kanda, Mitsuro, Ishibashi, Keiichiro, Hata, Taishi, Kobayashi, Michiya, Hasegawa, Junichi, Fukunaga, Mutsumi, Takagane, Akinori, Otsuji, Toshio, Miyake, Yasuhiro, Nagase, Michitaka, Sakamoto, Junichi, Matsuoka, Masaki, Oba, Koji, Mishima, Hideyuki“…Treatment was repeated every 3 weeks until disease progression or termination of the study. The primary endpoint was progression-free survival; the secondary endpoints were toxicity, overall response rate, time-to-treatment failure, and overall survival. …”
Publicado 2015
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88498“…Luc-MSCs (5 × 10(5)) isolated from the luciferase transgenic mice with FVB background were injected at 4 days after fracture. All animals were terminated at 5 weeks after fracture; examinations included bioluminescence-based in vivo imaging, micro-computer tomography, mechanical testing, histology, immunohistochemistry, and double immunofluorescence staining. …”
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88499por Schiff, Michael, Combe, Bernard, Dörner, Thomas, Kremer, Joel M, Huizinga, Thomas W, Veenhuizen, Melissa, Gill, Anne, Komocsar, Wendy, Berclaz, Pierre-Yves, Ortmann, Robert, Lee, Chin“…Primary end point was American College of Rheumatology 20% (ACR20) response at 24 weeks. This study was terminated early due to futility. RESULTS: Most patients had moderate-to-high baseline disease activity. …”
Publicado 2015
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88500por Schroeder, Casey L. C., Narra, Hema P., Rojas, Mark, Sahni, Abha, Patel, Jignesh, Khanipov, Kamil, Wood, Thomas G., Fofanov, Yuriy, Sahni, Sanjeev K.“…We further characterized novel sRNAs from typhus (R. prowazekii and R. typhi) and spotted fever (R. rickettsii and R. conorii) groups for their promoters and Rho-independent terminators using Bacterial Promoter Prediction Program (BPROM) and TransTermHP prediction algorithms, respectively. …”
Publicado 2015
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