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  1. 88561
    “…It is indicated that xyl-doc possesses a long conservative 5′-UTR with a complex secondary structure encompassing at least two perfect stem-loops which are potential candidates for controlling the transcriptional termination. In the last step, we employed an oxygen-independent flavin-based fluorescent protein (FbFP) as a quantitative reporter to analyze promoter activity and 5′-UTR function in vivo. …”
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    Function analysis of 5′-UTR of the cellulosomal xyl-doc cluster in Clostridium papyrosolvens
  2. 88562
    “…Methods One group of parents to prenatally diagnosed children with a congenital heart defect (n = 5) and one group of individuals with experience of termination of a pregnancy following a prenatal diagnosis of a congenital heart defect (n = 5) were purposefully recruited. …”
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    Involvement of persons with lived experience of a prenatal diagnosis of congenital heart defect: an explorative study to gain insights into perspectives on future research
  3. 88563
    “…The N-terminally truncated pyroglutamate Aβ(3−42) (Aβ(pE3−42)) and Aβ(4−42) peptides are known to be highly abundant in the brain of Alzheimer's disease (AD) patients. …”
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    Synergistic Effect on Neurodegeneration by N-Truncated Aβ(4−42) and Pyroglutamate Aβ(3−42) in a Mouse Model of Alzheimer's Disease
  4. 88564
    “…In study I, normal diet was administrated while, in study II & III high cholesterol and high sucrose diet was given, respectively along with prepared nutraceutical drinks to synchronize their therapeutic effect for a period of 56 days. At the termination of trial, Feed & drink intakes, body weight, total cholesterol, LDL, HDL, triglycerides, glucose and insulin levels were measured. …”
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    Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders
  5. 88565
    “…CONCLUSION: Despite the limitation related to premature termination, this study provides no data to support the routine implementation of resuscitation protocols incorporating StO(2) >80% at two or more muscle sites as a target. …”
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    Targeting skeletal muscle tissue oxygenation (StO(2)) in adults with severe sepsis and septic shock: a randomised controlled trial (OTO-StS Study)
  6. 88566
    “…Through phosphorylating the C-terminals of the NMDAR GluN2 subunits, PKD1 down-regulates the activity of remaining (non-internalized) surface NMDARs. …”
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    Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats
  7. 88567
    “…At the time of the interim analysis, 132 patients had completed 52 weeks of treatment (24 patients were 2-year study completers; 96 patients were still ongoing; and 12 patients had discontinued after 52 weeks); 57 patients were still ongoing in the first 1-year of treatment; and 82 patients terminated prior to week 52. The cognitive composite Z-score showed impairment at double-blind baseline (-1.09). …”
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    S73. EFFECT OF LURASIDONE ON COGNITION IN ADOLESCENTS WITH SCHIZOPHRENIA: INTERIM ANALYSIS OF A 2-YEAR OPEN-LABEL EXTENSION STUDY
  8. 88568
    “…BACKGROUND: Primary prevention implantable cardioverter‐defibrillators (ICDs) reduce mortality in selected patients with left ventricular systolic dysfunction by delivering therapies (antitachycardia pacing or shocks) to terminate potentially lethal arrhythmias; inappropriate therapies also occur. …”
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    Device Therapies Among Patients Receiving Primary Prevention Implantable Cardioverter‐Defibrillators in the Cardiovascular Research Network
  9. 88569
    “…METHODS: In this study, we used microarrays to analyze transcriptomes of terminally differentiated retinal ganglion cell (RGC) and retinal pigment epithelium (RPE) lineages, as well as intermediate retinal progenitor cells of optic vesicles (OVs) derived from hiPSCs. …”
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    Expression profiling of cell-intrinsic regulators in the process of differentiation of human iPSCs into retinal lineages
  10. 88570
    “…When treatment was terminated, no rebound of neuroinflammation occurred and histopathological improvement was preserved for at least 75 days without treatment. …”
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    Teriflunomide attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations
  11. 88571
    “…The particularly large number of basal dendrites in HL2/L3 PCs and the distinctive cable elongation of their terminals imply that ~25 NMDA-spikes could be generated independently and simultaneously in these cells, as compared to ~14 in L2/3 PCs from the rat somatosensory cortex. …”
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    Human Cortical Pyramidal Neurons: From Spines to Spikes via Models
  12. 88572
    “…If it is technically feasible and can be safely accomplished, termination of second stage labor by operative vaginal delivery is indicated in any condition threatening the mother or fetus that is likely to be relieved by delivery. …”
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    Prevalence and Outcome of Operative Vaginal Delivery among Mothers Who Gave Birth at Jimma University Medical Center, Southwest Ethiopia
  13. 88573
    “…BACKGROUND: The first pathology observed in Parkinson’s disease (PD) is ‘dying back’ of striatal dopaminergic (DA) terminals. Connexin (Cx)30, an astrocytic gap junction protein, is upregulated in the striatum in PD, but its roles in neurodegeneration remain elusive. …”
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    Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model
  14. 88574
    “…CD8(+) T cells expressing intermediate levels (CX3CR1(INT)) are defined as peripheral memory, those expressing the highest levels (CX3CR1(HI)) are effector memory/terminally differentiated and those lacking CX3CR1 (CX3CR1(NEG)) are classified as central memory. …”
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    Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8(+) T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients
  15. 88575
    “…Her hemodynamic status stabilized after red blood cell transfusion, and venoarterial extracorporeal membrane oxygenation was subsequently terminated. Transthoracic echocardiography showed a sigmoid septum; dobutamine-infused Doppler echocardiography revealed a significant outflow gradient, and continuous monitoring showed Brockenbrough–Braunwald sign, which confirmed a diagnosis of latent left ventricular outflow tract obstruction due to a sigmoid septum. …”
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    Conventional cardiopulmonary resuscitation-induced refractory cardiac arrest due to latent left ventricular outflow tract obstruction due to a sigmoid septum: a case report
  16. 88576
    “…Papers that research pediatrics, pregnant, or terminally ill patients will also be excluded, since their medication management is typically more complex. …”
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    Important Design Features of Personal Health Records to Improve Medication Adherence for Patients with Long-Term Conditions: Protocol for a Systematic Literature Review
  17. 88577
    “…Moreover, whole-genome sequencing combined with CRISPR/Cas9 mediated gene-editing identified a novel functional protein Mtc6p, which was prematurely terminated at Tyr251 by deletion of a single cytosine at 755 loci of its ORF in the T1 mutant. …”
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    Mutational Mtc6p attenuates autophagy and improves secretory expression of heterologous proteins in Kluyveromyces marxianus
  18. 88578
    “…SPWs were prominently emerging at the termination of proximal high amplitude propagating pressure waves (HAPWs); we termed this motor pattern HAPW-SPWs; hence, SPWs were often not a pan-colonic event. …”
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    Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry
  19. 88579
    “…The preferred reaction mechanism for the perfectly ordered spinel is phase separation throughout the sodiation range, while in the disordered spinel, the phase separation terminates in the 0.625 < x < 0.875 concentration range and is followed by a solid solution insertion reaction. …”
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    Ab Initio Study of Sodium Insertion in the λ-Mn(2)O(4) and Dis/Ordered λ-Mn(1.5)Ni(0.5)O(4) Spinels
  20. 88580
    “…CONCLUSION: Fifteen up-regulated proteins (e.g., Isopropylmalate isomerase LeuC, transcription-repair-coupling factor Mfd, and phosphoglucose isomerase PGI) and thirteen down-regulated proteins (e.g., TonB-dependent transporter ZMO1522, transcription termination factor Rho, and S1/P1 nuclease ZMO0127) were identified as candidate proteins related to all the stress conditions, implying that these proteins are potential biomarkers for the improvement of Z. mobilis ZM4 to resist complex biomass-derived inhibitors. …”
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    Proteomic and metabolomic analysis of the cellular biomarkers related to inhibitors tolerance in Zymomonas mobilis ZM4
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