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88681por Beswick, Emily, Glasmacher, Stella A, Dakin, Rachel, Newton, Judith, Carson, Alan, Abrahams, Sharon, Chandran, Siddharthan, Pal, Suvankar“…Failure to recruit and/or retain participants can cause insufficiently representative samples, terminated trials or invalid conclusions. This study investigates patient-specific factors affecting recruitment and retention of pwMND to MND-SMART. …”
Publicado 2021
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88682“…No significant difference was detected in the prevalence of genomic abnormality in fetuses with nasal bone hypoplasia alone and in combination with other ultrasound abnormalities (13/32 vs 18/52; χ(2) = 0.31, P > 0.05). The pregnancy was terminated in 21 fetuses detected with chromosomal abnormality and 4 fetuses detected with pathogenic CNVs. …”
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88683“…Arterial blood samples were taken before initiating CPB, 30 minutes after starting CPB, then every half hourly till termination of CPB and after half an hour stay in the ICU post operatively to analyze primarily H+ ions, bicarbonates, lactate and strong ion difference. …”
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88684por Coyle, Chris, Ruddenklau, Amy, Prescott, Mel, Walters, Kirsty A, Campbell, Rebecca Elaine“…Serial tail tip blood sampling was used to measure pulsatile LH and fixed brains were collected and immunolabelled for vesicular GABA transporter (VGAT) to assess putative GABAergic terminals associated with GFP-labelled GnRH neurons. …”
Publicado 2021
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88685por Wang, Fei, Yuan, Bo, Xiao, Shan, Zhang, Jiao, Jia, Wenxi, Fang, Qi, Wang, Fang, Song, Qisheng, Ye, Gongyin“…All the ORFs were separated by conserved intergenic sequences which likely regulated the transcription termination and initiation. Our findings enhance the understanding of RNA viruses in weevil wasps and set the foundation for the future study of the association among weevils, weevil wasps, and RNA viruses. …”
Publicado 2021
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88686por Shi, Jian-yu, Bi, Yan-yan, Yu, Bian-fang, Wang, Qing-feng, Teng, Dan, Wu, Dong-ning“…Alternate Acceptor site (AA) and Alternate Promoter (AP) events directly affected the concentration of CD4T cells, and the level of CD8T cells was closely correlated with Alternate Terminator (AT) and Exon Skip (ES) events. Thus, the concentration of CD4T and CD8T cells in the CRC immune microenvironment was not specifically modulated by AS. …”
Publicado 2021
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88687por van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma J., van den Heuvel-Eibrink, Marry, Shmakov, Roman G., Boere, Ingrid, Gziri, Mina M., Ottevanger, Petronella B., Lok, Christianne A. R., Halaska, Michael, Shao, Long Ting, Struys, Ilana, van Dijk-Lokkart, Elisabeth M., Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, Amant, Frédéric“…Of 29 women who received chemotherapy prior to 12 weeks gestation, 17 (58.6%) were not aware of pregnancy, and 6 (20.7%) experienced a miscarriage (3 women [10.3%]) or decided to terminate their pregnancy (3 women [10.3%]). CONCLUSIONS AND RELEVANCE: This cohort study found that chemotherapy was associated with an increased risk of major congenital malformations only in the first 12 weeks of pregnancy. …”
Publicado 2021
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88688por Ma, Zhi, Yang, Huixia, Peng, Lin, Kuhn, Christina, Chelariu-Raicu, Anca, Mahner, Sven, Jeschke, Udo, von Schönfeldt, Viktoria“…Specimens obtained from legally terminated normal pregnancies were considered as control group (n = 18). …”
Publicado 2021
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88689por Puskarich, Michael A., Cummins, Nathan W., Ingraham, Nicholas E., Wacker, David A., Reilkoff, Ronald A., Driver, Brian E, Biros, Michelle H., Bellolio, Fernanda, Chipman, Jeffrey G., Nelson, Andrew C., Beckman, Kenneth, Langlois, Ryan, Bold, Tyler, Aliota, Matthew T., Schacker, Timothy W., Voelker, Helen T., Murray, Thomas A, Koopmeiners, Joseph S., Tignanelli, Christopher J.“…Due to a lower than expected hospitalization rate and low likelihood of a clinically important treatment effect, the trial was terminated early. INTERPRETATION: In this multicenter blinded RCT for outpatients with mild symptomatic COVID-19 disease, losartan did not reduce hospitalizations, though assessment was limited by low event rate. …”
Publicado 2021
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88690“…Results: Due to preliminary termination (COVID-19), 93 subjects completed the post-training and 60 subjects the follow-up session. …”
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88691por Schwartz, Ilan, Boesen, Mari E., Cerchiaro, Graziela, Doram, Craig, Edwards, Brett D., Ganesh, Aravind, Greenfield, Jamie, Jamieson, Scott, Karnik, Vikram, Kenney, Carol, Lim, Rachel, Menon, Bijoy K., Mponponsuo, Kwadwo, Rathwell, Sarah, Ryckborst, Karla J., Stewart, Breanne, Yaskina, Maryna, Metz, Luanne, Richer, Lawrence, Hill, Michael D.“…INTERPRETATION: There was no evidence that hydroxychloroquine reduced symptom duration or prevented severe outcomes among outpatients with proven COVID-19, but the early termination of our study meant that it was underpowered. …”
Publicado 2021
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88692por Velarde de la Cruz, Erandi, Wang, Lingyun, Bose, Deepanwita, Gangadhara, Sailaja, Wilson, Robert L., Amara, Rama R., Kozlowski, Pamela A., Aldovini, Anna“…After repeated rectal challenge with SHIV(BG505), two Group 1 animals remained uninfected at challenge termination. No significant differences were observed in post-infection viral loads between groups. …”
Publicado 2021
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88693por Alzahrani, Ali S, Alswailem, Meshael, Abbas, Bassam Bin, Qasem, Ebtesam, Alsagheir, Afaf, Al Shidhani, Azza, Al Sinani, Aisha, Al Badi, Maryam, Al-Maqbali, Ali, Al Shawi, Manal, Albunyan, Abdulhameed, Bin Nafisah, Abdulghani, Shi, Yufei“…We isolated DNA from peripheral blood and PCR-sequenced all exons and exon-intron boundaries of SCNN1A and, if negative, SCNN1B and SCNN1G using the Dideoxy Chain termination method. RESULTS: We found a total of 8 mutations in 13 families as follows: 6 mutations in SCNN1A, 1 in SCNN1B, and 1 in SCNN1G. …”
Publicado 2021
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88694“…A basic Leucine Zipper (bZIP) transcription factor protein is the candidate gene for bc-u. bZIP protein gene Phvul.005G124100 carries a unique non-synonymous mutation at codon 14 in the first exon (Pv05: 36,114,516 bases), resulting in a premature termination codon that causes a nonfunctional protein. …”
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88695por Zhao, Huajun, Wang, Haigang, Hu, Yifei, Xu, Dongqing, Yin, Chunlai, Han, Qiuju, Zhang, Jian“…More importantly, Ng(-)pIL-12 adjuvant triggered terminally differentiated effector memory responses with strong anti-HBV effects. …”
Publicado 2021
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88696por Vukicevic, Petar, Klisic, Aleksandra, Neskovic, Vojislava, Babic, Luka, Mikic, Aleksandar, Bogavac-Stanojevic, Natasa, Matkovic, Milos, Milićević, Vladimir, Aleksic, Nemanja, Kotur-Stevuljevic, Jelena“…Blood samples were taken at 6 time intervals: before surgery (t1), immediately after intervention (t2), 6 h (t3), 24 h (t4), 48 h (t5), and 96 h after termination of the operation (t6). RESULTS: IMA levels were higher in CPB than that in OPCAB baseline and rose in CPB group in t2 point. …”
Publicado 2021
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88697por Fisher, Fernando, Zhang, Yuanyuan, Vincent, Philippe F. Y., Gajewiak, Joanna, Gordon, Thomas J., Glowatzki, Elisabeth, Fuchs, Paul Albert, McIntosh, J. Michael“…The tight binding of Cy3-RgIA-5727 provided robust visualization of hair cell nAChRs juxtaposed to cholinergic efferent terminals in excised, unfixed cochlear tissue from mice. …”
Publicado 2021
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88698“…OUTCOME MEASURES: The primary outcome was occurrence of adverse events, which included standardized criteria for terminating exercise testing, blood oxygen saturation (SpO(2)) <80%, or acute mountain sickness score >2. …”
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88699“…Mean differences in E(an,acc) at STT termination ranged between −4.3 and 0.5 kJ and typical errors were between 0.6 and 2.1 kJ. …”
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88700por Zhang, Cangang, Lei, Lei, Yang, Xiaofeng, Ma, Kaili, Zheng, Huiqiang, Su, Yanhong, Jiao, Anjun, Wang, Xin, Liu, Haiyan, Zou, Yujing, Shi, Lin, Zhou, Xiaobo, Sun, Chenming, Hou, Yuzhu, Xiao, Zhengtao, Zhang, Lianjun, Zhang, Baojun“…Old mice had more CD8(+) T cells with a ‘progenitor’ and less ‘terminally’ exhausted phenotypes than young mice. Consistently, trajectory inference demonstrated that CD8(+) T cells preferentially differentiated into cytotoxic cells in old mice in contrast to exhausted cells in young mice. …”
Publicado 2021
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