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88881por Stingone, Jeanette A., Luben, Thomas J., Daniels, Julie L., Fuentes, Montserrat, Richardson, David B., Aylsworth, Arthur S., Herring, Amy H., Anderka, Marlene, Botto, Lorenzo, Correa, Adolfo, Gilboa, Suzanne M., Langlois, Peter H., Mosley, Bridget, Shaw, Gary M., Siffel, Csaba, Olshan, Andrew F.“…Depending on the pollutant, a maximum of 4,632 live-birth controls and 3,328 live-birth, fetal-death, or electively terminated cases had exposure data. Hierarchical regression models, adjusted for maternal demographics and tobacco and alcohol use, were constructed. …”
Publicado 2014
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88882por Amin, Asim, Dudek, Arkadiusz Z, Logan, Theodore F, Lance, Raymond S, Holzbeierlein, Jeffrey M, Knox, Jennifer J, Master, Viraj A, Pal, Sumanta K, Miller, Wilson H, Karsh, Lawrence I, Tcherepanova, Irina Y, DeBenedette, Mark A, Williams, W Lee, Plessinger, Douglas C, Nicolette, Charles A, Figlin, Robert A“…RESULTS: Thirteen patients (62%) experienced clinical benefit (9 partial responses, 4 with stable disease); however there were no complete responses in this group of intermediate and poor risk mRCC patients and enrollment was terminated early. Median PFS from registration was 11.2 months (95% CI 6.0, 19.4) and the median OS from registration was 30.2 months (95% CI 9.4, 57.1) for all patients. …”
Publicado 2015
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88883por Niewald, Marcus, Holtmann, Henrik, Prokein, Benjamin, Hautmann, Matthias G., Rösler, Hans-Peter, Graeber, Stefan, Dzierma, Yvonne, Ruebe, Christian, Fleckenstein, Jochen“…CONCLUSIONS: Favorable laboratory results could not be translated into an enhanced pain relief in our patients. This trial was terminated after the interim analysis (127 patients randomized). …”
Publicado 2015
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88884por Szukiewicz, Dariusz, Bilska, Anna, Mittal, Tarun Kumar, Stangret, Aleksandra, Wejman, Jaroslaw, Szewczyk, Grzegorz, Pyzlak, Michal, Zamlynski, Jacek“…Both placental specimens and terminated cytotrophoblast cultures were fixed and embedded in paraffin before being immunostained for OXTR. …”
Publicado 2015
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88885por Takagi, Yusuke, Hosomi, Yukio, Oshita, Fumihiro, Okamoto, Hiroaki, Seki, Nobuhiko, Minato, Koichi, Aono, Hiromi, Yamada, Kouzo, Okuma, Yusuke, Hida, Naoya, Sakamoto, Takahiko, Miura, Yosuke, Yomota, Makiko, Satoh, Akira, Kunitoh, Hideo, Sakamaki, Kentaro, Shibuya, Masahiko, Watanabe, Koshiro“…Enrollment to the Level 0 cohort was terminated because two patients developed Grade 4 sepsis during later cycles. …”
Publicado 2015
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88886por Khoshnood, Babak, Loane, Maria, de Walle, Hermien, Arriola, Larraitz, Addor, Marie-Claude, Barisic, Ingeborg, Beres, Judit, Bianchi, Fabrizio, Dias, Carlos, Draper, Elizabeth, Garne, Ester, Gatt, Miriam, Haeusler, Martin, Klungsoyr, Kari, Latos-Bielenska, Anna, Lynch, Catherine, McDonnell, Bob, Nelen, Vera, Neville, Amanda J, O’Mahony, Mary T, Queisser-Luft, Annette, Rankin, Judith, Rissmann, Anke, Ritvanen, Annukka, Rounding, Catherine, Sipek, Antonin, Tucker, David, Verellen-Dumoulin, Christine, Wellesley, Diana, Dolk, Helen“…Study question What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for mandatory folic acid fortification of food does not exist? …”
Publicado 2015
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88887por Brendel, M, Jaworska, A, Herms, J, Trambauer, J, Rötzer, C, Gildehaus, F-J, Carlsen, J, Cumming, P, Bylund, J, Luebbers, T, Bartenstein, P, Steiner, H, Haass, C, Baumann, K, Rominger, A“…A total of 131 Aβ-PET recordings were acquired at baseline (12 months), follow-up 1 (16 months) and follow-up 2 (18 months, termination scan), whereupon histological and biochemical analyses of Aβ were performed. …”
Publicado 2015
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88888por Kim, Eugene, Tunset, Hanna Maja, Cebulla, Jana, Vettukattil, Riyas, Helgesen, Heidi, Feuerherm, Astrid Jullumstrø, Engebråten, Olav, Mælandsmo, Gunhild Mari, Johansen, Berit, Moestue, Siver Andreas“…Six treated and six control mice were terminated after 2 days of treatment, and the tumors excised for high resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS) and prostaglandin E2 (PGE2) enzyme immunoassay (EIA) analysis. …”
Publicado 2016
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88889por You, Abin, Cao, Manqing, Guo, Zhigui, Zuo, Bingfeng, Gao, Junrong, Zhou, Hongyuan, Li, Huikai, Cui, Yunlong, Fang, Feng, Zhang, Wei, Song, Tianqiang, Li, Qiang, Zhu, Xiaolin, Yin, Haifang, Sun, Huichuan, Zhang, Ti“…However, many patients have to adopt dose reduction or terminate the use of sorafenib because of side effects. …”
Publicado 2016
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88890por Dinet, Virginie, Ciccotosto, Giuseppe D., Delaunay, Kimberley, Borras, Céline, Ranchon-Cole, Isabelle, Kostic, Corinne, Savoldelli, Michèle, El Sanharawi, Mohamed, Jonet, Laurent, Pirou, Caroline, An, Na, Abitbol, Marc, Arsenijevic, Yvan, Behar-Cohen, Francine, Cappai, Roberto, Mascarelli, Frédéric“…Reduction of the number of bipolar cells was accompanied with disrupted dendrites, reduced expression of metabotropic glutamate receptor 6 at the dendritic tips and alteration of axon terminals in the OFF laminae of the inner plexiform layer. …”
Publicado 2016
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88891“…The NfBgl3A gene was hence fused to the cbh1 structural gene and assembled between the strong cbh1 promoter and cbh1 terminator to obtain pRS-NfBgl3A by using the DNA assembler method. pRS-NfBgl3A was transformed into the T. reesei uridine auxotroph strain TU-6. …”
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88892por Lafort, Yves, Greener, Ross, Roy, Anuradha, Greener, Letitia, Ombidi, Wilkister, Lessitala, Faustino, Skordis-Worrall, Jolene, Beksinska, Mags, Gichangi, Peter, Reza-Paul, Sushena, Smit, Jenni A., Chersich, Matthew, Delva, Wim“…Ever having used emergency contraception ranged from 2.4% in Mysore to 38.1% in Mombasa (p < 0.001), ever having been screened for cervical cancer from 0.0% in Tete to 29.0% in Durban (p < 0.001), and having gone to a health facility for a termination of an unwanted pregnancy from 15.0% in Durban to 93.7% in Mysore (p < 0.001). …”
Publicado 2017
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88893por Zhu, Feng‐cai, Hu, Shang‐Ying, Hong, Ying, Hu, Yue‐Mei, Zhang, Xun, Zhang, Yi‐Ju, Pan, Qin‐Jing, Zhang, Wen‐Hua, Zhao, Fang‐Hui, Zhang, Cheng‐Fu, Yang, Xiaoping, Yu, Jia‐Xi, Zhu, Jiahong, Zhu, Yejiang, Chen, Feng, Zhang, Qian, Wang, Hong, Wang, Changrong, Bi, Jun, Xue, Shiyin, Shen, Lingling, Zhang, Yan‐Shu, He, Yunkun, Tang, Haiwen, Karkada, Naveen, Suryakiran, Pemmaraju, Bi, Dan, Struyf, Frank“…Of the 1595 reported pregnancies, nine had congenital anomalies (five live infants, three elective terminations, one stillbirth) that were unlikely vaccination‐related (blinded data). …”
Publicado 2016
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88894por Leiss, Lina, Mutlu, Ercan, Øyan, Anne, Yan, Tao, Tsinkalovsky, Oleg, Sleire, Linda, Petersen, Kjell, Rahman, Mohummad Aminur, Johannessen, Mireille, Mitra, Sidhartha S., Jacobsen, Hege K., Talasila, Krishna M., Miletic, Hrvoje, Jonassen, Inge, Li, Xingang, Brons, Nicolaas H., Kalland, Karl-Henning, Wang, Jian, Enger, Per Øyvind“…With simultaneous removal of CD11b(+) immune and CD31(+) endothelial cells by fluorescence activated cell sorting (FACS), we obtained a population of tumour-associated glial cells, TAGs, expressing markers of terminally differentiaed glial cell types or glial progenitors. …”
Publicado 2017
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88895por Alemayehu, Mussie, Yebyo, Henock, Medhanyie, Araya Abrha, Bayray, Alemayehu, Fantahun, Misganaw, Goba, Gelila Kidane“…Study participants who did not understand their fertility cycle and when they were most likely to conceive after menstruation (adjusted odds ratio [AOR] = 2.0, 95% confidence interval [CI]: 1.1–3.7), having a previous abortion using medication (AOR = 3.3, CI: 1.83, 6.11), having multiple sexual partners in the preceding 12 months (AOR = 4.4, CI: 2.39,8.45), perceiving that the abortion procedure is not painful (AOR = 2.3, CI: 1.31,4.26), initiating sexual intercourse before the age of 18 years (AOR = 2.7, CI: 1.49, 5.23) and disclosure to a third-party about terminating the pregnancy (AOR = 2.1, CI: 1.2,3.83) were independent predictors of repeat abortion. …”
Publicado 2017
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88896por Verstovsek, Srdan, Mesa, Ruben A., Gotlib, Jason, Gupta, Vikas, DiPersio, John F., Catalano, John V., Deininger, Michael W. N., Miller, Carole B., Silver, Richard T., Talpaz, Moshe, Winton, Elliott F., Harvey, Jimmie H., Arcasoy, Murat O., Hexner, Elizabeth O., Lyons, Roger M., Paquette, Ronald, Raza, Azra, Jones, Mark, Kornacki, Deanna, Sun, Kang, Kantarjian, Hagop“…RESULTS: Patients were randomized (September 2009–April 2010) to ruxolitinib (n = 155) or placebo (n = 154). At termination, 27.7% of ruxolitinib-randomized patients and 25.2% (28/111) who crossed over from placebo were on treatment; no patients remained on placebo. …”
Publicado 2017
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88897por Ando, Maya, Fiesel, Fabienne C., Hudec, Roman, Caulfield, Thomas R., Ogaki, Kotaro, Górka-Skoczylas, Paulina, Koziorowski, Dariusz, Friedman, Andrzej, Chen, Li, Dawson, Valina L., Dawson, Ted M., Bu, Guojun, Ross, Owen A., Wszolek, Zbigniew K., Springer, Wolfdieter“…RESULTS: Under endogenous conditions, PINK1 p.I368N is expressed, imported, and N-terminally processed in healthy mitochondria similar to PINK1 wild type (WT). …”
Publicado 2017
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88898por Khan, Akram, Benthin, Cody, Zeno, Brian, Albertson, Timothy E., Boyd, John, Christie, Jason D., Hall, Richard, Poirier, Germain, Ronco, Juan J., Tidswell, Mark, Hardes, Kelly, Powley, William M., Wright, Tracey J., Siederer, Sarah K., Fairman, David A., Lipson, David A., Bayliffe, Andrew I., Lazaar, Aili L.“…RESULTS: Dose escalation in part A was well-tolerated without clinically significant hemodynamic changes. Part B was terminated after 39 of the planned 60 patients following a planned futility analysis. …”
Publicado 2017
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88899por He, Min-Ke, Le, Yong, Li, Qi-Jiong, Yu, Zi-Shan, Li, Shao-Hua, Wei, Wei, Guo, Rong-Ping, Shi, Ming“…More patients in the TACE group than in the HAIC group had the study treatment terminated early due to intolerable treatment-related adverse events or the withdrawal of consent (10 vs. 2, P = 0.026). …”
Publicado 2017
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88900por Werner, Julia, Hunsicker, Oliver, Schneider, Anja, Stein, Henryk, von Heymann, Christian, Freitag, Adrian, Feldheiser, Aarne, Wernecke, Klaus-Dieter, Spies, Claudia“…RESULTS: The trial was terminated early upon recommendation of an independent data monitoring committee due to futility for efficacy at a planned interim analysis. …”
Publicado 2018
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