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89001por Sandercock, Peter A. G., Darbyshire, Janet, DeMets, David, Fowler, Robert, Lalloo, David G., Munavvar, Mohammed, Staplin, Natalie, Warris, Adilia, Wittes, Janet, Emberson, Jonathan R.“…Requests for the release of unblinded primary outcome data to regulators at points when data were not mature required significant efforts in communication with the regulators by the DMC to avoid inappropriate early trial termination. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13063-022-06824-6.…”
Publicado 2022
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89002“…Upon further exploration of this code, SDA group were less likely to consult for oral contraception and more likely to contact a GP for induced termination of pregnancy compared to Non-SDA group (IRR 0.36; 95% CI 0.33–0.44 and IRR 2.94; 95% CI 1.58–5.46 respectively). …”
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89003“…RESULTS: There were no prematurely terminated procedures due to anticoagulation-related complications. …”
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89004por Vaiman, Anne, Fritz, Sébastien, Beauvallet, Christian, Boussaha, Mekki, Grohs, Cécile, Daniel-Carlier, Nathalie, Relun, Anne, Boichard, Didier, Vilotte, Jean-Luc, Duchesne, Amandine“…The frameshift leads to a premature termination codon. Accordingly, mRNA and protein analyses in muscles from wild-type and affected animals revealed a decrease in MYH3 expression in affected animals, probably due to mRNA decay, as well as an absence of the MYH3 protein in these animals. …”
Publicado 2022
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89005por Wang, Shi-Lin, Zhang, Zhen-Hua, Fan, Ye-Yang, Huang, De-Run, Yang, Yao-Long, Zhuang, Jie-Yun, Zhu, Yu-Jun“…Two homozygous KO lines were produced, each having a 1-bp insertion in OsPUB3 which caused frameshift mutation and premature termination. Compared with the recipient and a transgenic-negative control, both mutants showed significant decreases in grain weight and size. …”
Publicado 2022
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89006“…We extracted disease type and setting, population, therapeutic drug, primary endpoint, input parameters and sample size results from two-stage designs, and historical control reference, and study termination status. RESULTS: Among examined 29 trials, 12 trials (41%) appropriately provided key input parameters and sample size results from two-stage design implementation. …”
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89007“…Subjects included 28 fathers whose male partners had experienced pregnancy or childbirth complicated by a significant congenital abnormality or aneuploidy, termination of pregnancy, fetal death in-utero, stillbirth, admission to the neonatal intensive care unit or special care nursery or significant maternal morbidity, such as a postpartum haemorrhage or an emergency postpartum hysterectomy. …”
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89008por Erviti, Juan, Wright, James, Bassett, Ken, Ben-Eltriki, Mohamed, Jauca, Ciprian, Saiz, Luis Carlos, Leache, Leire, Gutiérrez-Valencia, Marta, Perry, Thomas L“…At the time the trial was terminated early, a non-significantly higher risk of cardiovascular mortality was observed with evolocumab, which was numerically greater in our readjudication. …”
Publicado 2022
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89009“…ABSTRACT: Plasma cell neoplasms including multiple myeloma (MM) and related terminally differentiated B-cell neoplasms are characterized by secretion of monoclonal immunoglobulin and stepwise development from a preneoplastic clonal B and/or plasma cell proliferation called monoclonal gammopathy of undetermined significance (MGUS). …”
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89010por Abud, Kelly C. O., Machado, Clarisse M., Vilas Boas, Lucy S., Maeda, Nair Y., Carvalho, Eloisa S., Souza, Maria Francilene S., Gaiolla, Paula V., Castro, Claudia R. P., Pereira, Juliana, Rabinovitch, Marlene, Lopes, Antonio Augusto“…Post-cardiopulmonary bypass (CPB) inflammatory reaction was analyzed by measuring serum levels of 36 inflammatory proteins (immunoblotting) 4 h after its termination. Postoperative hemodynamics was assessed using continuous recording of PAP and SAP with calculation of PAP/SAP ratio. …”
Publicado 2023
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89011“…This has inspired us to pool individual patient data (IPD) from ongoing, paused, prematurely-terminated, or completed randomized controlled trials (RCTs) in real-time, to find an effective treatment as quickly as possible in light of the pandemic crisis. …”
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89012por Salmani, Arvin, Keshavarz, Hooman, Akbari, Majid, Kharrazifard, Mohammad Javad, Varmazyari, Shabnam, Khami, Mohammad Reza“…Before the COVID pandemic terminated data collection, a total of 16 schools (438 students) managed to respond (37%). …”
Publicado 2023
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89013por Haider, Ahmed, Elghazawy, Nehal H., Dawood, Alyaa, Gebhard, Catherine, Wichmann, Thomas, Sippl, Wolfgang, Hoener, Marius, Arenas, Ernest, Liang, Steven H.“…As such, research into peripheral biomarkers has taken advantage of cardiac autonomic denervation in PD, allowing the differential diagnosis between PD and multiple system atrophy with probes that visualize sympathetic nerve terminals in the myocardium. Further, α-synuclein has recently gained attention as a potential peripheral biomarker in PD. …”
Publicado 2023
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89014por Mestiri, Sarra, Merhi, Maysaloun, Inchakalody, Varghese P., Taib, Nassiba, Smatti, Maria K., Ahmad, Fareed, Raza, Afsheen, Ali, Fatma H., Hydrose, Shereena, Fernandes, Queenie, Ansari, Abdul W., Sahir, Fairooz, Al-Zaidan, Lobna, Jalis, Munir, Ghoul, Mokhtar, Allahverdi, Niloofar, Al Homsi, Mohammed U., Uddin, Shahab, Jeremijenko, Andrew Martin, Nimir, Mai, Abu-Raddad, Laith J., Abid, Fatma Ben, Zaqout, Ahmed, Alfheid, Sameer R., Saqr, Hassan Mohamed Hassan, Omrani, Ali S., Hssain, Ali Ait, Al Maslamani, Muna, Yassine, Hadi M., Dermime, Said“…Moreover, we found that high frequencies of CD4+ terminally differentiated memory T cells were associated with a greater reduction of spike-specific activated CD4+ T cells. …”
Publicado 2023
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89015por Rotter, Gabriele, Teut, Michael, Schleicher, Romy, Dell'Oro, Melanie, Ortiz, Miriam, Binting, Sylvia, Tissen-Diabaté, Tatjana, Roll, Stephanie, Michalsen, Andreas, Staab, Doris, Wolfarth, Bernd, Brinkhaus, Benno“…Due to the coronavirus disease 2019 (COVID-19) pandemic, relevant changes to the study protocol included online in addition to “in-presence” group interventions, closing the study arm EP and premature trial termination before randomization of 120 intended patients. …”
Publicado 2023
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89016por Shah, Tayyab, McCarthy, Marianne, Nasir, Irem, Archer, Herb, Ragheb, Elio, Kluger, Jonathan, Kashyap, Nitu, Paredes, Carlos, Patel, Prashant, Lu, Jing, Kandel, Prakash, Song, Christopher, Khan, Mustafa, Huang, Haocheng, Ul Haq, Faheem, Ahmad, Rami, Howes, Christopher, Cambi, Brian, Lancaster, Gilead, Cleman, Michael, Dela Cruz, Charles, Parise, Helen, Lansky, Alexandra“…As part of the standard of care, patients received remdesivir (87%), dexamethasone (92%), tocilizumab (18%), baricitinib (2%), prophylactic/therapeutic anticoagulation (98%) and aspirin (91%). The trial was terminated early by the data and safety monitoring board for futility. …”
Publicado 2023
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89017por Ludwikowska, Kamila M., Popiel, Aneta, Matkowska-Kocjan, Agnieszka, Olbromski, Mateusz J., Biela, Mateusz, Wójcik, Marta, Szenborn, Filip, Wielgos, Katarzyna, Pielka-Markiewicz, Ewa, Zaryczański, Janusz, Kursa, Miron B., Szenborn, Leszek“…We did not observe any significant T cells or B cells subset abnormalities in the PIMS group compared to the CONTROL group three weeks after a second dose except for terminally differentiated effector memory T cells that were higher in PIMS group (p < 0.0041). …”
Publicado 2023
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89018por Choi, Sun Mi, Mo, Yosep, Bang, Ji-Young, Ko, Young Gyun, Ahn, Yoon Hae, Kim, Hye Young, Koh, Jaemoon, Yim, Jae-Joon, Kang, Hye-Ryun“…RESULTS: In the histological analysis of explanted human lung tissues, the terminally fibrotic areas contained a larger number of macrophages and monocytes than the early fibrotic areas of the lungs. …”
Publicado 2023
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89019por Heida, Annejet, van der Does, Willemijn F. B., van Schie, Mathijs S., van Staveren, Lianne N., Taverne, Yannick J. H. J., Bogers, Ad J. J. C., de Groot, Natasja M. S.“…GRAPHICAL ABSTRACT: The supervulnerable period after AF termination is not determined by conduction heterogeneity during SR and PACs. …”
Publicado 2022
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89020por Jacquesson, Alain“…Il a piloté l'informatisation des bibliothèques de l'Université de Genève de 1981 à 1988 et a assuré la direction des bibliothèques municipales de la Ville de Genève de 1988 à 1993. Il a terminé sa carrière à la bibliothèque de Genève qu'il a dirigée de 1993 à 2007. …”
Publicado 2010
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