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  1. 89261
    “…ABSTRACT: Small proline-rich protein 2A and 2D (SPRR2A and SPRR2D) provide barrier function in terminally differentiated stratified squamous epithelia through the epidermal differentiation complex. …”
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    Small Proline-Rich Protein 2A and 2D Are Regulated by the RBM38-p73 Axis and Associated with p73-Dependent Suppression of Chronic Inflammation
  2. 89262
    “…In vitro, this mutation negates the canonical donor splice site and creates two different alternative sites, both resulting in frameshifts and predicted early termination of the protein (p.Val44fs*50, p.Pro72fs*90). …”
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    In Vitro Splicing Assay Proves the Pathogenicity of Intronic Variants in MRAP
  3. 89263
    “…Each replicate was terminated, measured, and evaluated when 40% of larvae had reached prepupal stage. …”
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    Growth Performance, Waste Reduction Efficiency and Nutritional Composition of Black Soldier Fly (Hermetia illucens) Larvae and Prepupae Reared on Coconut Endosperm and Soybean Curd Residue with or without Supplementation
  4. 89264
    “…Methods : Recruitment for the TCC-Cardiac trial was terminated shortly after the World Health Organization announced COVID-19 as a global pandemic. …”
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    Trials and Tribulations: mHealth Clinical Trials in the COVID-19 Pandemic
  5. 89265
    “…Worldwide, around 50 million people have dementia, and there are nearly 10 million new cases every year. δ-secretase, also known as asparagine endopeptidase (AEP) or legumain (LGMN), is a lysosomal cysteine protease that cleaves peptide bonds C-terminally to asparagine residues in both amyloid precursor protein (APP) and tau, mediating the amyloid-β and tau pathology in AD. …”
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    Network-based identification of miRNAs and transcription factors and in silico drug screening targeting δ-secretase involved in Alzheimer's disease
  6. 89266
    “…We built a bidirectional Long Short-Term Memory Deep Neural Network (biLSTM) model for detecting the presence of PCa in men which combined the previously-identified phenotypic features (CD8(+)CD45RA(-)CD27(-)CD28(-) (CD8(+) Effector Memory cells), CD4(+)CD45RA(-)CD27(-)CD28(-) (CD4(+) Effector Memory cells), CD4(+)CD45RA(+)CD27(-)CD28(-) (CD4(+) Terminally Differentiated Effector Memory Cells re-expressing CD45RA), CD3(-)CD19(+) (B cells), CD3(+)CD56(+)CD8(+)CD4(+) (NKT cells) with Age. …”
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    Prostate Cancer: Early Detection and Assessing Clinical Risk Using Deep Machine Learning of High Dimensional Peripheral Blood Flow Cytometric Phenotyping Data
  7. 89267
    “…BACKGROUND: Mitochondrial transcription termination factor 3 (MTERF3) is a negative regulator of mitochondrial transcription. …”
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    Expression of MTERF3 gene in breast carcinoma and the relationship with clinicopathological characteristics
  8. 89268
    “…Phenotypical profiling showed that PD-1+CD96+CD8+ TILs exhibited a terminally exhausted effector phenotype with high levels of T-cell immunoglobulin mucin receptor 3 (TIM-3) and granzyme B (GZMB) and extremely low levels of proinflammatory cytokines and cytotoxic molecules. …”
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    Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer
  9. 89269
    “…Two novel, likely pathogenic variants were detected in one family (FZD4: Cys450ter), and a likely pathogenic frame shift termination variant was detected in one unrelated individual (LRP5: Ala919CysfsTer67). …”
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    A Survey of Multigenic Protein-Altering Variant Frequency in Familial Exudative Vitreo-Retinopathy (FEVR) Patients by Targeted Sequencing of Seven FEVR-Linked Genes
  10. 89270
    “…RESULTS: Cohort 3 was prematurely terminated because of slow accrual after 25 patients with advanced squamous NSCLC had been enrolled between 10 October 2018, and 3 March 2019. …”
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    Efficacy and safety of camrelizumab plus apatinib as second-line treatment for advanced squamous non-small cell lung cancer
  11. 89271
    “…Alternative splicing of FXN also leads to expression of N-terminally acetylated extra-mitochondrial frataxin (76–210) named isoform E because it was discovered in erythrocytes. …”
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    Simultaneous Quantification of Mitochondrial Mature Frataxin and Extra-Mitochondrial Frataxin Isoform E in Friedreich’s Ataxia Blood
  12. 89272
    “…Delirium is one of the most common neuropsychiatric syndromes among hospitalized cancer patients with incidence ranging from 25% to 40% and rates of up to 85% in the terminally ill. Data on the incidence, risk factors, duration, and outcomes of delirium in critically ill cancer patients with COVID-19 are lacking. …”
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    Delirium in Critically Ill Cancer Patients With COVID-19
  13. 89273
    “…The heart function was evaluated by echocardiography. The rats were terminated at the end of the 10(th) or 13(th) week. …”
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    Ginkgo Biloba Extract Reduces Cardiac and Brain Inflammation in Rats Fed a HFD and Exposed to Chronic Mental Stress through NF-κB Inhibition
  14. 89274
    “…We conducted metabolic phenotyping during feeding period, and harvested brain and blood at termination. Fatty acid (FA) composition was analyzed in cortex and red blood cells (RBC) using GC-MS. …”
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    Mechanisms Mediating the Protective Effects of Eicosapentaenoic Acid in Brain of the APPswePS1dE9 Alzheimer's Mouse Model
  15. 89275
    “…A gene reversion system was also employed with plasmids pDUP3 and pDIS3 engineered to contain the ADH1 terminator and an overlap extension PCR-mediated approach combined with CRISPR-Cas9 targeting at the NEUT5 neutral locus. …”
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    Rapid Hypothesis Testing in Candida albicans Clinical Isolates Using a Cloning-Free, Modular, and Recyclable System for CRISPR-Cas9 Mediated Mutant and Revertant Construction
  16. 89276
    “…To test the RV RF strain for its tolerance for peptide insertions, we constructed a reverse genetics system. NSP3 was C-terminally tagged with SARS-CoV-2 spike peptides of up to 193 amino acids in length. …”
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    Using Species a Rotavirus Reverse Genetics to Engineer Chimeric Viruses Expressing SARS-CoV-2 Spike Epitopes
  17. 89277
    “…RESULTS: A total of 172 patients (84 receiving remote care and 88 receiving in-home physician care [control group]) were randomized; enrollment was terminated early because of COVID-19. The mean (SD) age was 69.3 (18.0) years, 97 patients (56.4%) were female, 77 (45.0%) were White, and 42 (24.4%) lived alone. …”
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    Remote vs In-home Physician Visits for Hospital-Level Care at Home: A Randomized Clinical Trial
  18. 89278
    “…Direct neuronal reprogramming, the process whereby a terminally differentiated cell is converted into an induced neuron without traversing a pluripotent state, has tremendous therapeutic potential for a host of neurodegenerative diseases. …”
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    Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo
  19. 89279
    “…Two women in their third trimester had a termination of pregnancy by cesarean section, and one of the neonates had early neonatal death due to perinatal asphyxia. …”
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    Maternal-Fetal Characteristics of Pregnant Women With Severe COVID Disease and Maternal-Neonatal Characteristics of Neonates With Early-Onset SARS-CoV-2 Infection: A Prospective Data Analysis
  20. 89280
    “…Serotonergic denervation in the subcortical and cortical limbic regions is associated with apathy, depression, and anxiety in PD. Noradrenergic terminals loss plays a critical role in RBD and was shown to exceed locus coeruleus pathology in PD using 11C-MeNER PET. …”
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    Molecular Imaging in Parkinsonian Disorders—What’s New and Hot?
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