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  1. 1040381
    “…The results indicated that WJP can alleviate visceral hypersensitivity in IBS-D model rats, possibly mediated by downregulating the expression of TNF-α, p-MEK1/2, p-ERK1, and p-ERK2 in the colon tissue. At the same time, WJP also affects downregulating the expression of p-MEK1/2, p-ERK1, and p-ERK2 in the hippocampus tissue.…”
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    Online Artículo Texto
    Wenshen-Jianpi prescription, a Chinese herbal medicine, improves visceral hypersensitivity in a rat model of IBS-D by regulating the MEK/ERK signal pathway
  2. 1040382
    “…RESULTS: The incorporation of M‐mode OCT probes in these nonendoscopic GI devices safely and effectively enabled M‐mode OCT imaging, facilitating real‐time device placement guidance and contact sensing in vivo. …”
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    Passively scanned, single‐fiber optical coherence tomography probes for gastrointestinal devices
  3. 1040383
    “…Using proposed simple and fast method, there is an interplay between volume-risk relationship and NTCP of OARs to judge real-time normal organ risk level or alter the treatment margins, particularly concern to individual factors such as comorbidities, genetic predisposition, and other lifestyle choices even at high displacement errors >5 mm SD range.…”
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    Online Artículo Texto
    Normal Tissue Risk Estimation Using Biological Knowledge-Based Fuzzy Logic in Volumetric Modulated Arc Therapy of Prostate Cancer: Rectum
  4. 1040384
    “…Digital pathologist labels can reduce challenges associated with human annotations, including labor, time, inter‐ and intra‐reader variability, and can help bridge the gap between prostate radiology and pathology by enabling the training of reliable machine learning models to detect and localize prostate cancer on MRI.…”
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    Online Artículo Texto
    Bridging the gap between prostate radiology and pathology through machine learning
  5. 1040385
    “…WHAT IS KNOWN AND OBJECTIVE: Timely and appropriate dosing of antibiotics is essential for the treatment of bacterial sepsis. …”
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    Online Artículo Texto
    Pharmacokinetics of piperacillin and tazobactam in critically Ill patients treated with continuous kidney replacement therapy: A mini‐review and population pharmacokinetic analysis
  6. 1040386
    “…RESULTS: A total of 178 patients were enrolled in the study, with a mean follow-up time of 28.6 ± 3.82 months. The positive result of the bacteria isolated test was observed in 144 cases (80.9%). …”
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    Risk factors of transport gap bending deformity in the treatment of critical-size bone defect after bone transport
  7. 1040387
    “…METHODS: English databases such as Cochrane, PubMed, Google Scholar, Web of Science and Persian databases such as SID, MagIran and IranDoc were searched with a time limit of 2019 to 2022. Two researchers independently evaluated the quality of the entered studies based on Cochrane handbook. …”
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    Online Artículo Texto
    The effect of cognitive behavior therapy on anxiety and depression during COVID-19 pandemic: a systematic review and meta-analysis
  8. 1040388
    por Sedilla, Keneth B., Maeda, Takafumi
    Publicado 2022
    “…METHODS: Ten young male adults participated in an experimental trial where local cooling was permitted at any time during the behavioral assessment during passive exposure to humid heat. …”
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    Autonomic thermoregulatory responses and subjective thermal perceptions upon the initiation of thermal behavior among resting humans in hot and humid environment
  9. 1040389
    “…The target genes of dysregulated tsRNAs were predicted and the biological effects and potential signaling pathways of these target genes were explored by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Quantitative real‐time polymerase chain reaction (qRT‐PCR) was used to validate 11 differentially expressed tRFs with 12 pairs CCA and adjacent normal tissues. …”
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    RNA‐sequencing reveals the expression profiles of tsRNAs and their potential carcinogenic role in cholangiocarcinoma
  10. 1040390
    “…Methods: Patients aged ≥18 years with a positive SARS-CoV-2 real-time polymerase chain reaction assay admitted to 4 academic hospitals in Atlanta, Georgia, between February 15 and May 16, 2020, were included. …”
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    Secondary Bacterial Pneumonias and Bloodstream Infections in Patients Hospitalized with COVID-19
  11. 1040391
    “…METHODS: Micro-RNA-130b-3p (miR-130b-3p) expression in mTORC1-activated and control cells was examined by quantitative real-time PCR (qRT-PCR). MiR-130b-3p levels and their correlation with mTORC1 activity were evaluated by analyzing publicly available databases and in-house head and neck squamous cell carcinoma (HNSCC) tissues. …”
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    STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth
  12. 1040392
    “…Conventional fungal culture and PCR techniques are limited by low sensitivity, long turn-around time, and are insufficient for differentiating between infection and colonization. …”
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    S2.3c High-resolution digital DNA melting: a breakthrough in diagnosing IMI?
  13. 1040393
    “…RESULT: Hypoxia/reoxygenation induced primary (pri-)miR-19b, mature miR-19b, and c-Jun expression over time in a comparable timeframe. c-Jun silencing by transfection with its specific siRNA reduced both pri-miR-19b and mature miR-19b levels. …”
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    c-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock
  14. 1040394
    por Hu, Yajie, Liu, Yang, Li, Shize
    Publicado 2022
    “…Mice models of cold stress with different intensities were established (cold exposure gradients were 22 °C, 16 °C, 10 °C and 4 °C, and time gradients of each temperature were 2 h, 4 h, 6 h, 8 h, 10 h and 12 h). …”
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    Effect of Acute Cold Stress on Neuroethology in Mice and Establishment of Its Model
  15. 1040395
    “…Repeated measures test was applied for data recorded at three time points. RESULTS: A significant elevation in white blood cell (WBC) count was observed in COVID-positive intervention (p < 0.001) and control groups (p = 0.003), indicating no role of intervention on change in WBC number. …”
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    Effect of breathing intervention in patients with COVID and healthcare workers
  16. 1040396
    “…RESULTS: Of 8643 eligible children, a total of 393 adolescents had an ADHD diagnosis (284 [72.2%] boys; mean [SD] age, 10.03 [0.30] years; mean [SD] H/I Strengths and Difficulties Questionnaire score, 5.05 [2.29]) and were age-, sex-, and H/I score–matched with 393 adolescents without ADHD diagnosis at time zero. Compared with adolescents without diagnosis, those with an ADHD diagnosis reported similar QOL on CHU9D (mean difference, −0.03; 95% CI, −0.07 to 0.01; P = .10), general health (mean difference, 0.11; 95% CI, −0.04 to 0.27; P = .15), happiness (mean difference, −0.18; 95% CI, −0.37 to 0.00; P = .05), and peer trust (mean difference, 0.65; 95% CI, 0.00 to 1.30; P = .05). …”
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    Association of Attention-Deficit/Hyperactivity Disorder Diagnosis With Adolescent Quality of Life
  17. 1040397
    por Wendel, Eva Maria, Thonke, Helen Sophie, Bertolini, Annikki, Baumann, Matthias, Blaschek, Astrid, Merkenschlager, Andreas, Karenfort, Michael, Kornek, Barbara, Lechner, Christian, Pohl, Daniela, Pritsch, Martin, Schanda, Kathrin, Schimmel, Mareike, Thiels, Charlotte, Waltz, Stephan, Wiegand, Gert, Anlar, Banu, Barisic, Nina, Blank, Christian, Breu, Markus, Broser, Philip, Della Marina, Adela, Diepold, Katharina, Eckenweiler, Matthias, Eisenkölbl, Astrid, Freilinger, Michael, Gruber-Sedlmayr, Ursula, Hackenberg, Annette, Iff, Tobias, Knierim, Ellen, Koch, Johannes, Kutschke, Georg, Leiz, Steffen, Lischetzki, Grischa, Nosadini, Margherita, Pschibul, Alexander, Reiter-Fink, Edith, Rohrbach, Doris, Salandin, Michela, Sartori, Stefano, Schlump, Jan-Ulrich, Stoffels, Johannes, Strautmanis, Jurgis, Tibussek, Daniel, Tüngler, Victoria, Utzig, Norbert, Reindl, Markus, Rostásy, Kevin
    Publicado 2022
    “…RESULTS: One hundred sixteen children (f:m = 57:59) with MOGAD were included and initially diagnosed with ADEM (n = 59), unilateral ON (n = 12), bilateral ON (n = 16), myelitis (n = 6), neuromyelitis optica spectrum disorder (n = 8) or encephalitis (n = 6). The median follow-up time was 3 years in monophasic and 5 years in relapsing patients. …”
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    Temporal Dynamics of MOG Antibodies in Children With Acquired Demyelinating Syndrome
  18. 1040398
    “…Further research on interventions to improve timely referral and reduce in-hospital delays in care provision is recommended to facilitate emergency care services for women with hypertensive emergencies.…”
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    Maternal near-miss and mortality associated with hypertensive disorders of pregnancy remote from term: a multicenter observational study in Ghana
  19. 1040399
    “…In 10 cases (45%), loss of reduction was identified, while a substantial loss of reduction (> 6 mm) was only observed in one patient (4.5%). A shorter time interval between index stabilization surgery and hardware removal significantly corresponded to immediate loss of reduction (11.0 ± 5.6 vs. 30.0 ± 20.8 months; p = 0.007), as hardware removal within one year following index stabilization was significantly associated with immediate loss of reduction (p = 0.027; relative risk 3.4; odds ratio 11.67). …”
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    Low rate of substantial loss of reduction immediately after hardware removal following acromioclavicular joint stabilization using a suspensory fixation system
  20. 1040400
    “…These results may be helpful in preoperatively managing patients’ expectations regarding sports- and work-related outcomes and provide tangible data on the expectable time frame of the individual return to sports and work trajectory. …”
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    High return to sports and return to work rates after anatomic lateral ankle ligament reconstruction with tendon autograft for isolated chronic lateral ankle instability
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