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  1. 1040781
    “…Epidemiologic Information (EI) regarding prevalence and incidence data of rare diseases is sparse and current paradigms of identifying, extracting, and curating EI rely upon time-intensive, error-prone manual processes. With these limitations, a clear understanding of the variation in epidemiology and outcomes for rare disease patients is hampered. …”
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    Precision information extraction for rare disease epidemiology at scale
  2. 1040782
    “…METHODS: The antiherpes virus activity of Fr.8.3 was mainly characterized by cytopathic effects, real-time PCR detection of viral gene replication and expression levels, western blotting, viral titer determination and plaque reduction experiments. …”
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    Antiviral activities of Artemisia vulgaris L. extract against herpes simplex virus
  3. 1040783
    “…The treatment effects lessened over time: at 6 months the difference in medians was 4.7 points for Decision Conflict Scale (P=0.060) and 0 points for Decision Regret Scale (P=0.35). …”
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    Randomized Clinical Trial to Evaluate an Atrial Fibrillation Stroke Prevention Shared Decision‐Making Pathway
  4. 1040784
    “…Post-transformation to FHCs, improved timings, additional human resources, new services, fully functioning laboratories, and well stocked pharmacies were observed and linked to improved service utilization and reduced cost of care. …”
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    Of primary health care reforms and pandemic responses: understanding perspectives of health system actors in Kerala before and during COVID-19
  5. 1040785
    “…Whereas the literature growth rates were highest for uncharacterized or understudied genes until 2005–2010 compared with other groups of genes, they became negative thereafter. At the same time, literature for anyhow well-studied genes started to grow explosively with threshold T10 (≥ 10 FPEs). …”
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    About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature
  6. 1040786
    “…The mean preoperative UDVA significantly improved from 0.53 ± 0.02 logMAR to 0.07 ± 0.01 logMAR and 0.08 ± 0.01 logMAR at 6 and 12 months, respectively (P < 0.001) while the mean preoperative logMAR CDVA showed non-significant change over time throughout the study (P = 0.135). At the end of the study, 41 eyes (85.4%) achieved UDVA of 20/25 or better and no eye lost any lines of CDVA. …”
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    Twelve-month outcomes of single-step transepithelial photorefractive keratectomy for moderate hyperopia and hyperopic astigmatism
  7. 1040787
    “…Mobile VCT was provided to participants at an assigned time and place. Demographic characteristics and risk-taking and protective features of the MSM were collected via online questionnaires. …”
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    Risk and Protective Profile of Men Who Have Sex With Men Using Mobile Voluntary HIV Counseling and Testing: Latent Class Analysis
  8. 1040788
    “…In exploratory analyses, atogepant 30 and 60 mg were associated with nominal improvements in MSQ RFP and EF domains, other AIM-D outcomes, and HIT-6 scores at the earliest time point (week 4) and throughout the 12-week treatment period. …”
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    Effect of Atogepant for Preventive Migraine Treatment on Patient-Reported Outcomes in the Randomized, Double-blind, Phase 3 ADVANCE Trial
  9. 1040789
    “…This has become particularly relevant, given the need for real-time sensor data that could help lower health care costs by reducing the frequency of clinical assessments performed by specialists and improve access to health assessments (eg, for people living in remote areas or older adults living at home). …”
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    Development of an Open-source and Lightweight Sensor Recording Software System for Conducting Biomedical Research: Technical Report
  10. 1040790
    “…As of data cutoff date on Jul 13th, 2021, the median follow-up time was 21.7 months (95%CI 19.8–22.5). For FAS population, the IRC-assessed ORR was 26.5% (95%CI 19.2–34.9%), and disease control rate (DCR) was 56.8% (95%CI 47.9–65.4%). …”
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    Efficacy and safety of KL-A167 in previously treated recurrent or metastatic nasopharyngeal carcinoma: a multicenter, single-arm, phase 2 study
  11. 1040791
    “…Associations between physical activity measurements, QLQC30 and MY20 scores, and time from the start of treatment were estimated using a linear mixed model with a random intercept. …”
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    Association of patient activity bio-profiles with health-related quality of life in patients with newly diagnosed multiple myeloma: a prospective observational cohort study
  12. 1040792
    “…Finally, quantitative real-time polymerase chain reaction (qPCR) was used to detect the changes in non-coding RNAs and key mRNAs in the pancreatic tissues of patients with CP and PDAC. …”
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    Multi-level integrative analysis of the roles of lncRNAs and differential mRNAs in the progression of chronic pancreatitis to pancreatic ductal adenocarcinoma
  13. 1040793
    “…Future actions should be focused on appropriate timely action plans for the prevention and control of T2DM from early years of life.…”
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    Gender and urban–rural residency based differences in the prevalence of type-2 diabetes mellitus and its determinants among adults in Naghadeh: Results of IraPEN survey
  14. 1040794
    “…We observed that the average rating of overall health and overall QOL at the time of diagnosis was 5.4. After one year of follow-up, the average rating of overall health and overall QOL was found to be 3.4. …”
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    Quality of Life Assessment With European Organisation for Research and Treatment of Cancer Questionnaire (Head and Neck Module 43) and Its Clinicopathological Correlation Among Patients Treated for Oral Squamous Cell Carcinoma: An Exploratory Study
  15. 1040795
    “…Given the low certainty of evidence, this potentially life-saving therapy warrants further studies to identify the optimal timing, dosage, treatment duration, and patient population that will benefit most from IVVC monotherapy. …”
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    Intravenous vitamin C monotherapy in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
  16. 1040796
    por Lucena Perico, L, MacNaughton, W K
    Publicado 2023
    “…RESULT(S): PAR2 activation by 2fLI promoted wound healing compared to 2fO or vehicle control at the 24-hr time point (p<0.05). PAR2 activation had no effect on proliferation at the wound edge and did not affect apoptosis but did enhance lamellipodia/filopodia formation (p<0.001). …”
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    A6 PROTEASE-ACTIVATED RECEPTOR (PAR)-2 ACTIVATION ENHANCES EPITHELIAL WOUND HEALING MIGRATION THROUGH SRC AND RAC1 PATHWAYS
  17. 1040797
    “…A Cox proportional hazards model was used to assess time-related risk of future onset of CD. RESULT(S): 4385 subjects were included. …”
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    A39 HEALTHY FIRST-DEGREE RELATIVES FROM MULTIPLEX FAMILIES VERSUS SIMPLEX HARBOR A HIGHER RISK OF DEVELOPING CROHN'S DISEASE AND ARE ASSOCIATED WITH SUBCLINICAL INFLAMMATION AND ALTERED MICROBIOME COMPOSITION
  18. 1040798
    “…This responsibility was often deferred to the dietitian, thereby minimizing the role that physicians play or believe they have in its management. A lack of time during clinical encounters was also a key contributing factor. …”
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    A288 PHYSICIAN PERSPECTIVES OF MALNUTRITION CARE IN NOVA SCOTIA: A MORE-2-EAT (M2E) NOVA SCOTIA PHASE 2 QUALITATIVE SUBSTUDY
  19. 1040799
    por Cai, B, Wilson, A
    Publicado 2023
    “…PURPOSE: We aim to evaluate the pattern of PBE of CD patients at time of diagnosis (prior to drug exposure) and with each subsequent treatment; and if baseline PBE or any changes seen with drug exposures are predictive of treatment response. …”
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    A205 EVALUATING THE ASSOCIATION BETWEEN PERIPHERAL BLOOD EOSINOPHILS AND DRUG RESPONSE IN CROHN'S DISEASE: CONTINUING ANALYSIS
  20. 1040800
    “…Mean age at diagnosis was 13.2 years (IQR = 11.20 to 15. 20). Median time to IFX initiation after diagnosis was 5 days (IQR :3-14).Median IFX dose #1: was 8.4 mg/kg (IQR = 5. 8 to 10). 90% of patient had an IFX optimisation (increasing dose and/or shortening intervals) after dose 3 or dose 4. …”
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    A203 EARLY PROACTIVE DRUG MONITORING STRATEGY OF INFLIXIMAB AS MONOTHERAPY FOR INFLAMMATORY BOWEL DISEASE IN PAEDIATRIC PATIENTS IS ASSOCIATED WITH GOOD SUSTAINED CLINICAL REMISSION
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